{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:13:34Z","timestamp":1790957614419,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173190"],"award-info":[{"award-number":["81173190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500310"],"award-info":[{"award-number":["81500310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["ysxk-2010"],"award-info":[{"award-number":["ysxk-2010"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project Management Bureau in Jiangsu Province","award":["LZ11191"],"award-info":[{"award-number":["LZ11191"]}]},{"name":"National Science and Technology Major Project of the Ministry of Science and Technology of China-Significant New Drugs Creation","award":["2011ZX09102-002-07"],"award-info":[{"award-number":["2011ZX09102-002-07"]}]},{"name":"Postgraduate Research & Innovation Project of Jiangsu Province","award":["KYLX15_1000"],"award-info":[{"award-number":["KYLX15_1000"]}]},{"name":"Postgraduate Research & Innovation Project of Jiangsu Province","award":["CXLX12_ 0587"],"award-info":[{"award-number":["CXLX12_ 0587"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the cardioprotective effect of salvianolic acid B (Sal B) on acute myocardial infarction (AMI) in rats and its potential mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The AMI model was established in rats to study the effect of Sal B on AMI. Haematoxylin\u2013eosin (HE) staining was used to evaluate the pathological change in AMI rats. Immunofluorescence and TUNEL staining were used to detect autophagy and apoptosis of myocardial cells in hearts of AMI rats, respectively. Protein expression of apoptosis-related, autophagy-related and angiogenesis-related proteins were examined by Western blot.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Sal B attenuated myocardial infarction significantly compared with that of the model group. Rats administered with Sal B showed higher inhibition rate of infarction and lower infarct size than those of the model group. Moreover, Sal B decreased the serum levels of creatine kinase, lactate dehydrogenase and malondialdehyde, while increased such level of superoxide dismutase significantly compared with those of the model group. Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sal B has cardioprotective effect on AMI and Sal B may be a promising candidate for AMI treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12567","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T12:27:19Z","timestamp":1462278439000},"page":"941-952","source":"Crossref","is-referenced-by-count":62,"title":["Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis"],"prefix":"10.1093","volume":"68","author":[{"given":"Chao","family":"Lin","sequence":"first","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoguo","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Kuai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijun","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jing","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Preclinical Medicine, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]},{"name":"Jiangsu Key Laboratory for Pharmacolgy and Safety Evaluation of Chinese Materia Medica , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Bian","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing,","place":["China"]},{"name":"Jiangsu Key Laboratory for Pharmacolgy and Safety Evaluation of Chinese Materia Medica , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"2024103012542075400_jphp12567-cit-0001","doi-asserted-by":"crossref","first-page":"e112891","DOI":"10.1371\/journal.pone.0112891","article-title":"Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS ONE"},{"key":"2024103012542075400_jphp12567-cit-0002","first-page":"4799","article-title":"Short-term pretreatment with atorvastatin attenuates left ventricular dysfunction, reduces infarct size and apoptosis in acute myocardial infarction rats","volume":"7","author":"Chen","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"2024103012542075400_jphp12567-cit-0003","first-page":"1463","article-title":"Pathogenic factors and prognosis of non cardiac in patients with acute myocardial infarction","volume":"93","author":"Cao","year":"2013","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"2024103012542075400_jphp12567-cit-0004","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1179\/1351000215Y.0000000011","article-title":"Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: biochemical and ultrastructural evidence","volume":"20","author":"Hassan","year":"2015","journal-title":"Redox Rep"},{"key":"2024103012542075400_jphp12567-cit-0005","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s12013-014-0257-1","article-title":"Reduced apoptosis after acute myocardial infarction by simvastatin","volume":"71","author":"Luo","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"2024103012542075400_jphp12567-cit-0006","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/1440-1681.12309","article-title":"Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: role of autophagy","volume":"41","author":"Zhang","year":"2014","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2024103012542075400_jphp12567-cit-0007","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1871525713666150123152711","article-title":"Targeting apoptotic pathways in myocardial infarction: attenuated by phytochemicals","volume":"12","author":"Haidarali","year":"2014","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"2024103012542075400_jphp12567-cit-0008","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.82.11.1111","article-title":"Apoptosis: basic mechanisms and implications for cardiovascular disease","volume":"82","author":"Haunstetter","year":"1998","journal-title":"Circ Res"},{"key":"2024103012542075400_jphp12567-cit-0009","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3892\/mmr.2014.2676","article-title":"Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodelling by inhibiting the nuclear factor-kappa B signalling pathway","volume":"11","author":"He","year":"2015","journal-title":"Mol Med Rep"},{"key":"2024103012542075400_jphp12567-cit-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/eci.12188","article-title":"Apoptosis following myocardial infarction: cardiomyocytes and beyond\u2013comment on the paper \u2018Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial Infarction\u2019 by Forteza et al","volume":"44","author":"Roubille","year":"2014","journal-title":"Eur J Clin Invest"},{"key":"2024103012542075400_jphp12567-cit-0011","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jep.2013.09.044","article-title":"Shenyuan, an extract of American Ginseng and Corydalis Tuber formula, attenuates cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and oxidative stress in a porcine model of acute myocardial infarction","volume":"150","author":"Zhu","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"2024103012542075400_jphp12567-cit-0012","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.3390\/ijms16035618","article-title":"PEDF improves cardiac function in rats with acute myocardial infarction via inhibiting vascular permeability and cardiomyocyte apoptosis","volume":"16","author":"Zhang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2024103012542075400_jphp12567-cit-0013","doi-asserted-by":"crossref","first-page":"H2261","DOI":"10.1152\/ajpheart.01056.2010","article-title":"Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion","volume":"300","author":"Kanamori","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024103012542075400_jphp12567-cit-0014","first-page":"649","article-title":"Establishment of a cut-off value for the diagnosis of acute myocardial infarction using a new CK-MB activity measurement reagent containing anti-MtCK antibody","volume":"59","author":"Murakami","year":"2011","journal-title":"Rinsho Byori"},{"key":"2024103012542075400_jphp12567-cit-0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00380-010-0031-2","article-title":"Study on the relationship of cPLA2, CK-MB, and membrane phospholipid content in acute myocardial infarction","volume":"26","author":"Wei-hua","year":"2011","journal-title":"Heart Vessels"},{"key":"2024103012542075400_jphp12567-cit-0016","doi-asserted-by":"crossref","first-page":"e24681","DOI":"10.1371\/journal.pone.0024681","article-title":"Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS ONE"},{"key":"2024103012542075400_jphp12567-cit-0017","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1073\/pnas.82.8.2310","article-title":"Two tissue-specific isozymes of creatine kinase have closely matched amino acid sequences","volume":"82","author":"Pickering","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024103012542075400_jphp12567-cit-0018","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1016\/j.febslet.2008.10.039","article-title":"Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex","volume":"582","author":"Bong","year":"2008","journal-title":"FEBS Lett"},{"key":"2024103012542075400_jphp12567-cit-0019","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(98)01355-6","article-title":"Crystal structure of rabbit muscle creatine kinase","volume":"439","author":"Rao","year":"1998","journal-title":"FEBS Lett"},{"key":"2024103012542075400_jphp12567-cit-0020","doi-asserted-by":"crossref","first-page":"602","DOI":"10.4103\/0253-7613.100385","article-title":"Preventive effect of glycosaminoglycans from Amussium pleuronectus (Linne) on biomolecules, lactate dehydrogenase-isoenzyme and electrocardiographic patterns in isoproterenol-induced myocardial infarction in Wistar rats","volume":"44","author":"Saravanan","year":"2012","journal-title":"Indian J Pharmacol"},{"key":"2024103012542075400_jphp12567-cit-0021","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1016\/j.biomaterials.2013.07.031","article-title":"Enhanced infarct stabilization and neovascularization mediated by VEGF-loaded PEGylated fibrinogen hydrogel in a rodent myocardial infarction model","volume":"34","author":"Rufaihah","year":"2013","journal-title":"Biomaterials"},{"key":"2024103012542075400_jphp12567-cit-0022","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejphar.2010.02.050","article-title":"Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1alpha, SDF-1alpha and VEGF-B","volume":"635","author":"Lakkisto","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"2024103012542075400_jphp12567-cit-0023","doi-asserted-by":"crossref","first-page":"e34790","DOI":"10.1371\/journal.pone.0034790","article-title":"Glutaredoxin-1 overexpression enhances neovascularization and diminishes ventricular remodeling in chronic myocardial infarction","volume":"7","author":"Adluri","year":"2012","journal-title":"PLoS ONE"},{"key":"2024103012542075400_jphp12567-cit-0024","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00210-008-0287-6","article-title":"Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats","volume":"378","author":"He","year":"2008","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2024103012542075400_jphp12567-cit-0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2210-10-10","article-title":"Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling","volume":"10","author":"Jiang","year":"2010","journal-title":"BMC Pharmacol"},{"key":"2024103012542075400_jphp12567-cit-0026","doi-asserted-by":"crossref","first-page":"e0126640","DOI":"10.1371\/journal.pone.0126640","article-title":"Salvianolic acid B ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules through Src-regulated transcelluar pathway and paracellular pathway","volume":"10","author":"Pan","year":"2015","journal-title":"PLoS ONE"},{"key":"2024103012542075400_jphp12567-cit-0027","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbrc.2015.04.122","article-title":"Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-gamma and LXRalpha","volume":"462","author":"Yue","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"2024103012542075400_jphp12567-cit-0028","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jep.2005.10.021","article-title":"In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells","volume":"105","author":"Lin","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"2024103012542075400_jphp12567-cit-0029","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1078\/09447110260571634","article-title":"Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats","volume":"9","author":"Tang","year":"2002","journal-title":"Phytomedicine"},{"key":"2024103012542075400_jphp12567-cit-0030","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.86.9.939","article-title":"Altered patterns of gene expression in response to myocardial infarction","volume":"86","author":"Stanton","year":"2000","journal-title":"Circ Res"},{"key":"2024103012542075400_jphp12567-cit-0031","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/php.12247","article-title":"Hypericin as a marker for determination of myocardial viability in a rat model of myocardial infarction","volume":"90","author":"Jiang","year":"2014","journal-title":"Photochem Photobiol"},{"key":"2024103012542075400_jphp12567-cit-0032","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2013.12.027","article-title":"Myocardial infarction induces cognitive impairment by increasing the production of hydrogen peroxide in adult rat hippocampus","volume":"560","author":"Liu","year":"2014","journal-title":"Neurosci Lett"},{"key":"2024103012542075400_jphp12567-cit-0033","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","volume":"90","author":"Satoh","year":"1978","journal-title":"Clin Chim Acta"},{"key":"2024103012542075400_jphp12567-cit-0034","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur J Biochem"},{"key":"2024103012542075400_jphp12567-cit-0035","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/ajim.4700130302","article-title":"A retrospective cohort mortality study of males mining and milling attapulgite clay","volume":"13","author":"Waxweiler","year":"1988","journal-title":"Am J Ind Med"},{"key":"2024103012542075400_jphp12567-cit-0036","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.4238\/2014.October.20.7","article-title":"Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats","volume":"13","author":"Yang","year":"2014","journal-title":"Genet Mol Res"},{"key":"2024103012542075400_jphp12567-cit-0037","first-page":"103","article-title":"Utilization of LDH isoenzymes in the diagnosis of myocardial infarction","volume":"11","author":"Petersen","year":"1997","journal-title":"Clin Lab Manage Rev"},{"key":"2024103012542075400_jphp12567-cit-0038","first-page":"47","article-title":"Study of CK-MB activity in patients with acute myocardial infarction after percutaneous coronary intervention","author":"Emukhvari","year":"2015","journal-title":"Georgian Med News"},{"key":"2024103012542075400_jphp12567-cit-0039","first-page":"12","article-title":"Pharmacological correction of hypoxic and free-radical disorders in patients with acute myocardial infarction complicated by acute heart failure","volume":"73","author":"Livanov","year":"2010","journal-title":"Eksp Klin Farmakol"},{"key":"2024103012542075400_jphp12567-cit-0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/14756360500286070","article-title":"Status of some free radical scavenging enzymes in the blood of myocardial infarction patients","volume":"21","author":"Dwivedi","year":"2006","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2024103012542075400_jphp12567-cit-0041","doi-asserted-by":"crossref","first-page":"R879","DOI":"10.1152\/ajpregu.00075.2014","article-title":"Cardiac macrophages and apoptosis after myocardial infarction: effects of central MR blockade","volume":"307","author":"Rafatian","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2024103012542075400_jphp12567-cit-0042","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4161\/auto.6.2.11135","article-title":"Augmentation of autophagy by mTOR-inhibition in myocardial infarction: when size matters","volume":"6","author":"Buss","year":"2010","journal-title":"Autophagy"},{"key":"2024103012542075400_jphp12567-cit-0043","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00540-012-1494-3","article-title":"Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-kappa B and upregulation of autophagy","volume":"27","author":"Qiao","year":"2013","journal-title":"J Anesth"},{"key":"2024103012542075400_jphp12567-cit-0044","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3892\/ijmm.2014.1960","article-title":"Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation","volume":"34","author":"Lin","year":"2014","journal-title":"Int J Mol Med"},{"key":"2024103012542075400_jphp12567-cit-0045","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/CIRCULATIONAHA.113.003668","article-title":"National trends in heart failure hospitalization after acute myocardial infarction for medicare beneficiaries: 1998\u20132010","volume":"128","author":"Chen","year":"2013","journal-title":"Circulation"},{"key":"2024103012542075400_jphp12567-cit-0046","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/MCA.0000000000000178","article-title":"Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment","volume":"25","author":"Matsuzawa","year":"2014","journal-title":"Coron Artery Dis"},{"key":"2024103012542075400_jphp12567-cit-0047","first-page":"39","article-title":"Effect of smoking on serum xanthine oxidase and malondialdehyde levels in patients with acute myocardial infarction","volume":"65","author":"Ata","year":"2015","journal-title":"J Pak Med Assoc"},{"key":"2024103012542075400_jphp12567-cit-0048","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2015.04.010","article-title":"Possible mechanisms of C-reactive protein mediated acute myocardial infarction","volume":"760","author":"Fordjour","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"2024103012542075400_jphp12567-cit-0049","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/EDE.0000000000000227","article-title":"Risk of myocardial infarction immediately after alcohol consumption","volume":"26","author":"Mostofsky","year":"2015","journal-title":"Epidemiology"},{"key":"2024103012542075400_jphp12567-cit-0050","first-page":"890","article-title":"Pathomechanisms on cold stress induced acute myocardial infarction","volume":"41","author":"Tian","year":"2013","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"2024103012542075400_jphp12567-cit-0051","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00059-013-3915-y","article-title":"Diagnosis of myocardial infarction during long-standing coronary artery spasm and uptitration of nitroglycerin","volume":"40","author":"Avci","year":"2015","journal-title":"Herz"},{"key":"2024103012542075400_jphp12567-cit-0052","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/pds.3430","article-title":"Effect of evidence-based drug therapy on long-term outcomes in patients discharged after myocardial infarction: a nested case-control study in Italy","volume":"22","author":"Kirchmayer","year":"2013","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2024103012542075400_jphp12567-cit-0053","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijcard.2016.02.022","article-title":"The temporal trends of incidence, treatment, and in-hospital mortality of acute myocardial infarction over 15 years in a Taiwanese population","volume":"209","author":"Yin","year":"2016","journal-title":"Int J Cardiol"},{"key":"2024103012542075400_jphp12567-cit-0054","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s00108-008-2075-2","article-title":"Interventional therapy of acute myocardial infarction","volume":"49","author":"Zahn","year":"2008","journal-title":"Der Internist"},{"key":"2024103012542075400_jphp12567-cit-0055","first-page":"9","article-title":"Spectral quantum therapy as a part of resort's rehabilitation program for patients with myocardial infarction","author":"Kosov","year":"2001","journal-title":"Vopr Kurortol Fizioter Lech Fiz Kult"},{"key":"2024103012542075400_jphp12567-cit-0056","first-page":"316","article-title":"Routine invasive versus ischemia-guided strategy in patients with acute inferior ST-elevation myocardial infarction who received fibrinolytic therapy: a prospective randomized controlled pilot trial","volume":"23","author":"Abdul-Rahman","year":"2011","journal-title":"J Invasive Cardiol"},{"key":"2024103012542075400_jphp12567-cit-0057","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11655-009-0236-3","article-title":"Appraisal of the prognosis in patients with acute myocardial infarction treated with primary percutaneous coronary intervention","volume":"15","author":"Ma","year":"2009","journal-title":"Chin J Integr Med"},{"key":"2024103012542075400_jphp12567-cit-0058","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1161\/01.CIR.0000015697.59592.07","article-title":"No-reflow phenomenon and lesion morphology in patients with acute myocardial infarction","volume":"105","author":"Tanaka","year":"2002","journal-title":"Circulation"},{"key":"2024103012542075400_jphp12567-cit-0059","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0254-6272(12)60002-8","article-title":"Characteristics and advantages of traditional Chinese medicine in the treatment of acute myocardial infarction","volume":"31","author":"Liu","year":"2011","journal-title":"J Tradit Chin Med"},{"key":"2024103012542075400_jphp12567-cit-0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/med.20077","article-title":"New developments in the chemistry and biology of the bioactive constituents of Tanshen","volume":"27","author":"Wang","year":"2007","journal-title":"Med Res Rev"},{"key":"2024103012542075400_jphp12567-cit-0061","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.talanta.2005.09.041","article-title":"Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography and ESI-MS analysis","volume":"69","author":"Chen","year":"2006","journal-title":"Talanta"},{"key":"2024103012542075400_jphp12567-cit-0062","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/10286020008039903","article-title":"Salvianolic acid B protects the memory functions against transient cerebral ischemia in mice","volume":"2","author":"Du","year":"2000","journal-title":"J Asian Nat Prod Res"},{"key":"2024103012542075400_jphp12567-cit-0063","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1742-7843.2009.00490.x","article-title":"Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats","volume":"106","author":"Yang","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2024103012542075400_jphp12567-cit-0064","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jep.2011.03.070","article-title":"Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways","volume":"135","author":"Wang","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"2024103012542075400_jphp12567-cit-0065","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/cdd.2009.186","article-title":"Apaf-1-independent programmed cell death in mouse development","volume":"17","author":"Nagasaka","year":"2010","journal-title":"Cell Death Differ"},{"key":"2024103012542075400_jphp12567-cit-0066","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrc3462","article-title":"Apoptosis: refined and lethal","volume":"13","author":"Burgess","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"2024103012542075400_jphp12567-cit-0067","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.phymed.2012.05.012","article-title":"Involvement of NF-kappa B and Bcl2\/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A","volume":"19","author":"Mohan","year":"2012","journal-title":"Phytomedicine"},{"key":"2024103012542075400_jphp12567-cit-0068","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/ncb2788","article-title":"Emerging regulation and functions of autophagy","volume":"15","author":"Boya","year":"2013","journal-title":"Nat Cell Biol"},{"key":"2024103012542075400_jphp12567-cit-0069","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm1574","article-title":"The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress","volume":"13","author":"Nakai","year":"2007","journal-title":"Nat Med"},{"key":"2024103012542075400_jphp12567-cit-0070","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1073\/pnas.1406425111","article-title":"Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak","volume":"111","author":"Lindqvist","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024103012542075400_jphp12567-cit-0071","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/nm.3322","article-title":"Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2","volume":"19","author":"Maejima","year":"2013","journal-title":"Nat Med"},{"key":"2024103012542075400_jphp12567-cit-0072","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature13839","article-title":"Mesenchymal-endothelial transition contributes to cardiac neovascularization","volume":"514","author":"Ubil","year":"2014","journal-title":"Nature"},{"key":"2024103012542075400_jphp12567-cit-0073","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1158\/0008-5472.CAN-13-1072","article-title":"Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier","volume":"74","author":"Huang","year":"2014","journal-title":"Cancer Res"},{"key":"2024103012542075400_jphp12567-cit-0074","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1158\/0008-5472.CAN-12-0468","article-title":"RALBP1\/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization","volume":"72","author":"Lee","year":"2012","journal-title":"Cancer Res"},{"key":"2024103012542075400_jphp12567-cit-0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"2024103012542075400_jphp12567-cit-0076","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"2024103012542075400_jphp12567-cit-0077","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jfo.2014.11.007","article-title":"Anti-VEGF therapy in the treatment of anterior segment neovascularization secondary to central retinal vein occlusion","volume":"38","author":"Kabesha","year":"2015","journal-title":"J Fr Ophtalmol"},{"key":"2024103012542075400_jphp12567-cit-0078","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.phrs.2015.11.027","article-title":"Targeting VEGF in eye neovascularization: what's new?: a comprehensive review on current therapies and oligonucleotide-based interventions under development","volume":"103","author":"Amadio","year":"2016","journal-title":"Pharmacol Res"},{"key":"2024103012542075400_jphp12567-cit-0079","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.avsg.2008.02.017","article-title":"Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation","volume":"22","author":"van Weel","year":"2008","journal-title":"Ann Vasc Surg"},{"key":"2024103012542075400_jphp12567-cit-0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/hrt.2009.180414","article-title":"Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects","volume":"97","author":"Zachary","year":"2011","journal-title":"Heart"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12567","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/68\/7\/941\/60229813\/jphp12567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/68\/7\/941\/60229813\/jphp12567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T18:20:36Z","timestamp":1730312436000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/68\/7\/941\/6128317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,1]]},"references-count":80,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,1]]},"published-print":{"date-parts":[[2016,7,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12567","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,7]]},"published":{"date-parts":[[2016,7,1]]}}}