{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:16:14Z","timestamp":1780744574010,"version":"3.54.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Anhui University of Traditional Chinese Medicine"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51303006"],"award-info":[{"award-number":["51303006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial Natural Science Foundation","award":["1408085MH196"],"award-info":[{"award-number":["1408085MH196"]}]},{"name":"Provincial Natural Science Foundation","award":["KJ2012ZD09"],"award-info":[{"award-number":["KJ2012ZD09"]}]},{"name":"Provincial Natural Science Foundation","award":["10040606Q36"],"award-info":[{"award-number":["10040606Q36"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We developed Cur nanosuspension (Cur-NS) with PVPK30 and SDS as stabilizers to improve poor water solubility and short biological half-time of Cur.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Physicochemical characterization of Cur-NS was characterized systematically. The in-vitro dissolution, cytotoxicity and in-vivo pharmacokinetic experiments of Cur-NS were also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Scanning electron microscope indicated that the morphologies of Cur-NS were spherical or ellipsoidal in shape. X-ray diffraction verified that Cur was successfully developed as nanoparticles with an amorphous phase in Cur-NS. Fourier transform infrared spectroscopy suggested there was no degradation about Cur in the Cur-NS. Furthermore, the in-vitro study showed that the cumulative release of the Cur-NS was 82.16 \u00b1 2.62% within 34 h and the cytotoxicity of the Cur-NS against HepG2 cells was much better than raw Cur. Besides, in-vivo pharmacokinetics in rats by intravenous injection displayed that the in-vivo process of Cur-NS pertained to two-compartment model. Meanwhile, the t1\/2 and AUC0\u2013t of Cur-NS were enhanced by 11.0-fold and 4.2-fold comparing to Cur solution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The Cur-NS significantly increased the water solubility and half-time of Cur, suggesting its potential as a nanocarrier in the delivery of Cur for future clinical application.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12575","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T09:51:01Z","timestamp":1465552261000},"page":"980-988","source":"Crossref","is-referenced-by-count":47,"title":["Preparation and <i>in-vitro<\/i>\/<i>in-vivo<\/i> evaluation of curcumin nanosuspension with solubility enhancement"],"prefix":"10.1093","volume":"68","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiye","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine , Hefei, Anhui,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"2024103012555608600_jphp12575-cit-0001","doi-asserted-by":"crossref","first-page":"e1110","DOI":"10.4088\/JCP.14f09489","article-title":"A critical examination of studies on curcumin for depression","volume":"75","author":"Andrade","year":"2014","journal-title":"J Clin Psychiatry"},{"key":"2024103012555608600_jphp12575-cit-0002","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1517\/17425255.2014.972933","article-title":"Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues","volume":"10","author":"Turrini","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2024103012555608600_jphp12575-cit-0003","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1166\/jbn.2014.1786","article-title":"Synthesis, characterization and biological activities of curcumin nanospheres","volume":"10","author":"Arunraj","year":"2014","journal-title":"J Biomed Nanotechnol"},{"key":"2024103012555608600_jphp12575-cit-0004","first-page":"127","article-title":"Comparison of inhibitory effect of curcumin nanoparticles and free curcumin in human telomerase reverse transcriptase gene expression in breast cancer","volume":"3","author":"Kazemi-Lomedasht","year":"2013","journal-title":"Adv Pharm Bull"},{"key":"2024103012555608600_jphp12575-cit-0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-5173(02)00323-X","article-title":"Studies of curcumin and curcuminoids. 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