{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:06:42Z","timestamp":1740136002384,"version":"3.37.3"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012768","name":"Division of Pharmaceutical Sciences, Long Island University, Brooklyn Campus, NY","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012768","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the efficacy of topically applied 2% hydroxypropyl cellulose gels containing 0.5% fingolimod hydrochloride (FNGL) with or without 6% colloidal oatmeal in an in vivo model of atopic dermatitis (AD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>AD-like lesions were induced in SKH1\/Hr hairless mice and were treated with FNGL gels, non-medicated base gels and Elidel\u00ae cream for 6 weeks. The severity\/improvement of the lesions was assessed regularly using the Eczema Area and Severity Index (EASI), pH of the skin, transepidermal water loss, g\/m2\/h (TEWL), humidity and temperature. At the end of the experiments, the plasma levels of cytokines, FNGL and white blood cells were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The EASI score was almost unchanged for the vehicle-only groups compared to before the treatments, whereas the medicated groups showed a significant decrease in the overall EASI score (P &amp;lt; 0.01), although there was non-significant differences among them (P &amp;gt; 0.081). Both the FNGL groups also showed a significant (P \u02c2 0.05) reduction in blood WBC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study shows that the gels containing 0.50% FNGL and FNGL 0.50% plus 6% colloidal oatmeal have potential for the treatment of AD. The presence of colloidal oatmeal may provide additional benefits.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12588","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T01:08:22Z","timestamp":1469668102000},"page":"1268-1277","source":"Crossref","is-referenced-by-count":4,"title":["Fingolimod hydrochloride gel shows promising therapeutic effects in a mouse model of atopic dermatitis"],"prefix":"10.1093","volume":"68","author":[{"given":"Mayurkumar","family":"Tamakuwala","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University , Brooklyn, NY,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Ratna","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University , 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