{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:15Z","timestamp":1787015595280,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81274178"],"award-info":[{"award-number":["81274178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273582"],"award-info":[{"award-number":["81273582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302848"],"award-info":[{"award-number":["81302848"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008867","name":"Zhejiang Provincial Education Department","doi-asserted-by":"crossref","award":["Y201329949"],"award-info":[{"award-number":["Y201329949"]}],"id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation for University Young Key Teacher by the Education Department of Hunan Province"},{"DOI":"10.13039\/501100005225","name":"Construct Program of the Key Discipline in Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chlorogenic acid (CGA) is one of the most widely consumed polyphenols in diets and is recognized to be a natural hepatoprotective agent. Here, we evaluated the protective effect and the potential mechanism of CGA against \u0251-naphthylisothiocyanate (ANIT)-induced cholestasis and liver injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-five male 129\/Sv mice were administered with CGA, and ANIT challenge was performed at 75 mg\/kg on the 4th day. Blood was collected and subjected to biochemical analysis; the liver tissues were examined using histopathological analysis and signalling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Chlorogenic acid almost totally attenuated the ANIT-induced liver damage and cholestasis, compared with the ANIT group. Dose of 50 mg\/kg of CGA significantly prevented ANIT-induced changes in serum levels of alanine aminotransferase, alkaline phosphatases, total bile acid, direct bilirubin, indirect bilirubin (5.3-, 6.3-, 18.8-, 158-, 41.4-fold, P&amp;lt;0.001) and aspartate aminotransferase (4.6-fold, P&amp;lt;0.01). Expressions of the altered bile acid metabolism and transport-related genes were normalized by cotreatment with CGA. The expressions of interleukin 6, tumour necrosis factor-\u03b1 and suppressor of cytokine signalling 3 were found to be significantly decreased (1.2-fold, ns; 11.0-fold, P&amp;lt;0.01; 4.4-fold, P&amp;lt;0.05) in the CGA\/ANIT group. Western blot revealed that CGA inhibited the activation and expression of signal transducer and activator of transcription 3 and NF\u03baB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest that CGA inhibits both ANIT-induced intrahepatic cholestasis and the liver injury. This protective effect involves down-regulation of STAT3 and NF\u03baB signalling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.12592","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T11:43:47Z","timestamp":1467373427000},"page":"1203-1213","source":"Crossref","is-referenced-by-count":42,"title":["Chlorogenic acid inhibits cholestatic liver injury induced by \u03b1-naphthylisothiocyanate: involvement of STAT3 and NF\u03baB signalling regulation"],"prefix":"10.1093","volume":"68","author":[{"given":"Zhen","family":"Tan","sequence":"first","affiliation":[{"name":"Key Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University , Changsha,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[{"name":"Medical School of Ningbo University , 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Ningbo,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danjun","family":"Song","sequence":"additional","affiliation":[{"name":"Medical School of Ningbo University , Ningbo,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University , Changsha,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyun","family":"Dai","sequence":"additional","affiliation":[{"name":"Medical School of Ningbo University , Ningbo,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, National Cancer Institute, NIH , Bethesda, 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