{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:12:58Z","timestamp":1772647978306,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":1623,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study was designed to investigate pharmacological interaction between magnesium laxative and antacid in patients receiving opioid analgesic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data obtained from a total of 441 eligible patients receiving opioid analgesic for the first time were retrospectively analysed. The incidence of constipation, defined as stool-free interval of 3 days and more within the first week of opioid intake, was compared between patients who took laxative alone and those who received laxative in combination with antacid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Laxatives were prescribed in 74% of patients, among them 61% received antacids such as proton pump inhibitor and H2 receptor blocker. Magnesia was the most commonly used laxative (89%). Constipation occurred in 21% and 55% of patients with and without laxatives, respectively. Antacids reversed the laxative action of lower doses (&amp;lt;2000 mg\/day) but not higher doses (&amp;gt; 2000 mg\/day) of magnesia without affecting the effects of other laxatives. Therefore, it is suggested that both acid-dependent and acid-independent mechanisms may operate in the laxative action of magnesia, in which the former may be involved in the action of lower doses of magnesia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Care should be taken to avoid the unfavourable pharmacological interaction between low doses of magnesia and antacid.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12600","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T04:50:41Z","timestamp":1467348641000},"page":"1214-1221","source":"Crossref","is-referenced-by-count":6,"title":["Antacid attenuates the laxative action of magnesia in cancer patients receiving opioid analgesic"],"prefix":"10.1093","volume":"68","author":[{"given":"Hirokazu","family":"Ibuka","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics, Gifu University Graduate School of Medicine , Gifu,","place":["Japan"]},{"name":"Katorea Pharmacy , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Gifu University Hospital , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Gifu University Hospital , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Kagaya","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutics, Meiji Pharmaceutical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gifu University Graduate School of Medicine , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutomi","family":"Kinosada","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Gifu University Graduate School of Medicine , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Gifu University Hospital , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"issue":"Suppl. 1","key":"2024103012550145900_jphp12600-cit-0001","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.6004\/jnccn.2013.0212","article-title":"Early implementation of palliative care can improve patient outcomes","volume":"11","author":"Glare","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"issue":"9 Suppl.","key":"2024103012550145900_jphp12600-cit-0002","first-page":"7","article-title":"An overview of palliative care in cancer and AIDS","volume":"5","author":"Walsh","year":"1991","journal-title":"Oncology (Williston Park)"},{"key":"2024103012550145900_jphp12600-cit-0003","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1200\/JCO.2001.19.9.2542","article-title":"Strategies to manage the adverse effects of oral morphine: an evidence-based report","volume":"19","author":"Cherny","year":"2001","journal-title":"J Clin Oncol"},{"key":"2024103012550145900_jphp12600-cit-0004","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1526-5900(03)00556-X","article-title":"Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review","volume":"4","author":"McNicol","year":"2003","journal-title":"J Pain"},{"key":"2024103012550145900_jphp12600-cit-0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1526-4637.2008.00495.x","article-title":"The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1)","volume":"10","author":"Bell","year":"2009","journal-title":"Pain Med"},{"key":"2024103012550145900_jphp12600-cit-0006","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00520-009-0775-3","article-title":"Pharmaceutical interventions facilitate premedication and prevent opioid-induced constipation and emesis in cancer patients","volume":"18","author":"Ishihara","year":"2010","journal-title":"Support Care Cancer"},{"key":"2024103012550145900_jphp12600-cit-0007","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/AJP.0b013e318237d626","article-title":"A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction","volume":"28","author":"Ishihara","year":"2012","journal-title":"Clin J Pain"},{"key":"2024103012550145900_jphp12600-cit-0008","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/07315724.1990.10720349","article-title":"Magnesium bioavailability from magnesium citrate and magnesium oxide","volume":"9","author":"Lindberg","year":"1990","journal-title":"J Am Coll Nutr"},{"key":"2024103012550145900_jphp12600-cit-0009","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00228-014-1694-x","article-title":"Interaction of magnesium oxide with gastric acid secretion inhibitors in clinical pharmacotherapy","volume":"70","author":"Yamasaki","year":"2014","journal-title":"Eur J Clin Pharmacol"},{"key":"2024103012550145900_jphp12600-cit-0010","first-page":"93","article-title":"WHO guidelines for the use of analgesics in cancer pain","volume":"7","author":"Ventafridda","year":"1985","journal-title":"Int J Tissue React"},{"issue":"Suppl. 2","key":"2024103012550145900_jphp12600-cit-0011","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1016\/S1590-8658(01)80158-4","article-title":"Prophylaxis and treatment of non-steroidal anti-inflammatory drug-induced upper gastrointestinal side-effects","volume":"33","author":"Lazzaroni","year":"2001","journal-title":"Dig Liver Dis"},{"key":"2024103012550145900_jphp12600-cit-0012","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1368-5031.2005.00660.x","article-title":"Appropriate choice of proton pump inhibitor therapy in the prevention and management of NSAID-related gastrointestinal damage","volume":"59","author":"Singh","year":"2005","journal-title":"Int J Clin Pract"},{"key":"2024103012550145900_jphp12600-cit-0013","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/cncr.11817","article-title":"Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist","volume":"98","author":"Eisenberg","year":"2003","journal-title":"Cancer"},{"key":"2024103012550145900_jphp12600-cit-0014","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/00002018-200326040-00003","article-title":"Benefits and risks of newer treatments for chemotherapy-induced and postoperative nausea and vomiting","volume":"26","author":"Kovac","year":"2003","journal-title":"Drug Saf"},{"key":"2024103012550145900_jphp12600-cit-0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1191\/026921699677653615","article-title":"Morphine, constipation and performance status in advanced cancer patients","volume":"13","author":"Fallon","year":"1999","journal-title":"Palliat Med"},{"key":"2024103012550145900_jphp12600-cit-0016","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5056\/jnm14077","article-title":"Risk factors for postoperative ileus following orthopedic surgery: the role of chronic constipation","volume":"21","author":"Lee","year":"2015","journal-title":"J Neurogastroenterol Motil"},{"key":"2024103012550145900_jphp12600-cit-0017","volume-title":"National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology v.2.2015"},{"key":"2024103012550145900_jphp12600-cit-0018","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000171455","article-title":"NSAID-induced peptic ulcer disease: a critical review of pathogenesis and management","volume":"12","author":"Scheiman","year":"1994","journal-title":"Dig Dis"},{"key":"2024103012550145900_jphp12600-cit-0019","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1023\/A:1010687115298","article-title":"Prevention of acute NSAID-related gastroduodenal damage: a meta-analysis of controlled clinical trials","volume":"46","author":"Leandro","year":"2001","journal-title":"Dig Dis Sci"},{"issue":"Suppl. 1","key":"2024103012550145900_jphp12600-cit-0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000076554","article-title":"Challenges in managing NSAID-associated gastrointestinal tract injury","volume":"69","author":"Goldstein","year":"2004","journal-title":"Digestion"},{"key":"2024103012550145900_jphp12600-cit-0021","first-page":"133","article-title":"The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide","volume":"9","author":"Izzo","year":"1996","journal-title":"Magnes Res"},{"key":"2024103012550145900_jphp12600-cit-0022","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1476-5381.1994.tb16198.x","article-title":"Nitric oxide as a mediator of the laxative action of magnesium sulphate","volume":"113","author":"Izzo","year":"1994","journal-title":"Br J Pharmacol"},{"key":"2024103012550145900_jphp12600-cit-0023","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-2036.2000.00746.x","article-title":"The osmotic laxative magnesium sulphate activates the ileal brake","volume":"14","author":"Vu","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2024103012550145900_jphp12600-cit-0024","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1248\/bpb.34.238","article-title":"Effects of magnesium sulphate administration on aquaporin 3 in rat gastrointestinal tract","volume":"34","author":"Ikarashi","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"2024103012550145900_jphp12600-cit-0025","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.lfs.2010.11.013","article-title":"A mechanism by which the osmotic laxative magnesium sulphate increases the intestinal aquaporin 3 expression in HT-29 cells","volume":"88","author":"Ikarashi","year":"2011","journal-title":"Life Sci"},{"key":"2024103012550145900_jphp12600-cit-0026","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1172\/JCI33004","article-title":"When EGF is offside, magnesium is wasted","volume":"117","author":"Muallem","year":"2007","journal-title":"J Clin Invest"},{"key":"2024103012550145900_jphp12600-cit-0027","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0140-6736(97)10535-9","article-title":"Magnesium and phosphorus","volume":"352","author":"Weisinger","year":"1998","journal-title":"Lancet"},{"key":"2024103012550145900_jphp12600-cit-0028","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2169\/internalmedicine.45.1482","article-title":"Cathartic-induced fatal hypermagnesemia in the elderly","volume":"45","author":"Onishi","year":"2006","journal-title":"Intern Med"},{"key":"2024103012550145900_jphp12600-cit-0029","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jemermed.2011.09.004","article-title":"Hypermagnesemia in a constipated female","volume":"44","author":"Weng","year":"2013","journal-title":"J Emerg Med"},{"key":"2024103012550145900_jphp12600-cit-0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF00501005","article-title":"The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4\u2019-dihydroxydiphenyl-(pyridyl-2)-methane","volume":"274","author":"Forth","year":"1972","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12600","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jphp.12600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jphp.12600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/68\/9\/1214\/60229371\/jphp12600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/68\/9\/1214\/60229371\/jphp12600.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T18:22:07Z","timestamp":1730312527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/68\/9\/1214\/6128360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,1]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12600","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,9,1]]}}}