{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:52:10Z","timestamp":1792007530603,"version":"4.4.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008783","name":"National Research Council of Science & Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003621","name":"Korea government","doi-asserted-by":"publisher","award":["CRC-15-01-KIST"],"award-info":[{"award-number":["CRC-15-01-KIST"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Here, we hypothesized that Hovenia dulcis branch extract (HDB) and its active constituents ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD)-like skin lesions by modulating the T helper Th1\/Th2 balance in NC\/Nga mice and TNF-\u03b1- and IFN-\u03b3-induced production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in HaCaT cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>HaCaT cells were stimulated by TNF-\u03b1\/IFN-\u03b3 in the presence of HDB and its constituents. TARC and MDC were measured by ELISA and RT-PCR. For the in-vivo study, oral feeding of HDB was performed for 5 weeks with 2,4-dinitrochlorobenzene (DNCB) treatment every other day. The efficacy of HDB on parameters of DNCB-induced AD was evaluated morphologically, physiologically and immunologically.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>In-vitro studies showed that HDB and its constituents suppressed TNF-\u03b1\/IFN-\u03b3-induced production of TARC and MDC in HaCaT cells by inhibiting MAPK signalling. In-vivo studies showed that HDB regulated immunoglobulin (Ig) E and immunoglobulin G2a (IgG2a) levels in serum and the expression of mRNA for Th1- and Th2-related mediators in skin lesions. Histopathological analyses revealed reduced epidermal thickness and reduced infiltration of skin lesions by inflammatory cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results suggest that HDB inhibits AD-like skin diseases by regulating Th1 and Th2 responses in NC\/Nga mice and in HaCaT cells.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12640","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T13:41:16Z","timestamp":1475847676000},"page":"1465-1479","source":"Crossref","is-referenced-by-count":37,"title":["Effects of <i>Hovenia dulcis<\/i> Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-\u03b1\/IFN-\u03b3-induced chemokines production in HaCaT cells"],"prefix":"10.1093","volume":"68","author":[{"given":"Sue Ji","family":"Lim","sequence":"first","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]},{"name":"Convergence Research Center for Smart Farm Solution, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungsuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]},{"name":"Convergence Research Center for Smart Farm Solution, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Randy","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]},{"name":"Department of Biological Chemistry, Korea University of Science and Technology , Daejeon,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Jeong","family":"Nam","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]},{"name":"Department of Biological Chemistry, Korea University of Science and Technology , Daejeon,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu Won","family":"Nho","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology , Gangneung,","place":["Korea"]},{"name":"Convergence Research Center for Smart Farm Solution, Korea Institute of Science and Technology , 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