{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:26:53Z","timestamp":1752283613088,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308389\/2014-0"],"award-info":[{"award-number":["308389\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Apoio a Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["2281-2551\/14-2"],"award-info":[{"award-number":["2281-2551\/14-2"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The hexane (HEX) and dichloromethane (DCM) fractions from Blechnum binervatum, Blechnum brasiliense and Blechnum occidentale were studied about phytochemicals and biological properties using multitarget approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The chemical composition was performed by gas chromatography coupled with mass spectrometry detector (GC-MS) analysis. Antioxidant capacity was evaluated against free radicals and on lipid peroxidation. Monoamine oxidases (MAO) and cholinesterases enzymatic modulation, as well as effects on rat and human cells, were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The CG-MS analysis allowed the identification of a non-polar compound series, being neophytadiene the major constituent in all DCM fractions and in HEX fractions from B. binervatum and B. occidentale. In B. brasiliense HEX fraction, \u03b2-sitosterol was the main compound. In general, B. brasiliense DCM fraction presented the highest antioxidant activity, with IC50 values around 9, 2 and 1.2 times lower than those found for the other species, against HO\u02d9, NO\u02d9 and on lipid peroxidation, respectively. Regarding enzyme modulations, B. brasiliense DCM fraction presented higher MAO-A inhibition (IC50: 31.83 \u03bcg\/ml), with a better selectivity index (SI MAO-A\/MAO-B: 6.77). The lack of harmful effects was observed in rat cells, also highlighted in the stem cells for all Blechnum samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings encourage the search for multibinding natural products, mainly from B. brasiliense DCM fraction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12653","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T08:12:18Z","timestamp":1476691938000},"page":"89-98","source":"Crossref","is-referenced-by-count":5,"title":["Identification of compounds from non-polar fractions of <i>Blechnum<\/i> spp and a multitarget approach involving enzymatic modulation and oxidative stress"],"prefix":"10.1093","volume":"69","author":[{"given":"Juliana Maria de Mello","family":"Andrade","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacognosy, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Maurmann","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Laboratory, Faculty of Pharmacy, UFRGS , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Pranke","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Laboratory, Faculty of Pharmacy, UFRGS , Porto Alegre, RS,","place":["Brazil"]},{"name":"Stem Cell Research Institute , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabel Cristina Casanova","family":"Turatti","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP) , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto Peporine","family":"Lopes","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP) , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lia T","family":"Henriques","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2024103012563062400_jphp12653-cit-0001","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/S0031-9422(00)86654-6","article-title":"Phenolic compounds in ferns \u2013 III. 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