{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:48:08Z","timestamp":1784072888730,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cientifico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade, Brazil","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Estado do Maranh\u00e3o","doi-asserted-by":"publisher","award":["00668\/15"],"award-info":[{"award-number":["00668\/15"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To analyse the antineoplastic activity of fractions derived from the hydroalcoholic extract of Euterpe oleracea Mart. seed in the MCF-7 cell line and to identify the compounds responsible for the antineoplastic action.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cells were treated with 10, 20, 40 and 60 \u03bcg\/ml with the hexane, chloroform and ethyl acetate fraction (EAF) of the hydroalcoholic extract of a\u00e7a\u00ed seed, for 24 and 48 h. After treatment, cell viability was measured using MTT assay and cell death was assessed using the Annexin-Pi assay. The most cytotoxic fraction under study was analysed by mass spectrometry using an electrospray ionization source and a cyclotron analyser coupled to a Fourier transform. Data were analysed statistically by analysis of variance (ANOVA) or by Student's t-test, where appropriate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>All fractions caused significant reduction in the cell viability, but the EAF was the most cytotoxic (P &amp;lt; 0.001). It was observed the absence of significant annexin staining but increase Pi staining (P &amp;lt; 0.001). The EAF is composed of epicatechin, proanthocyanidin A2 and trimeric and tetrameric procyanidins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this study, we demonstrated that EAF was the most effective fraction in reducing cell viability and causing necroptosis in the MCF-7 cell.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12679","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T12:22:43Z","timestamp":1487334163000},"page":"714-721","source":"Crossref","is-referenced-by-count":28,"title":["Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the <i>Euterpe oleracea<\/i> Mart. seed in the MCF-7 cell line"],"prefix":"10.1093","volume":"69","author":[{"given":"Dayanne da S","family":"Freitas","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Adult and Children Health, Research Center of CCBS, Federal University of Maranh\u00e3o , S\u00e3o Lu\u00eds, Maranh\u00e3o,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Morgado-D\u00edaz","sequence":"additional","affiliation":[{"name":"Cellular Biology Program, Brazilian National Cancer Institute (INCA) , Rio de Janeiro, RJ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S","family":"Gehren","sequence":"additional","affiliation":[{"name":"Cellular Biology Program, Brazilian National Cancer Institute (INCA) , Rio de Janeiro, RJ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via C B","family":"Vidal","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Adult and Children Health, Research Center of CCBS, Federal University of Maranh\u00e3o , S\u00e3o Lu\u00eds, Maranh\u00e3o,","place":["Brazil"]},{"name":"Morphology Department, Federal University of Maranh\u00e3o , S\u00e3o Lu\u00eds, Maranh\u00e3o,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Maria T","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Center of Exact and Natural Sciences, Stadual University of Maranh\u00e3o , S\u00e3o Lu\u00eds, Maranh\u00e3o,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderson","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Petrole\u00f4mica and Forensic Laboratory, Chemistry Department, Federal University Esp\u00edrito Santo , Vit\u00f3ria, Esp\u00edrito Santo,","place":["Brazil"]},{"name":"Federal Institute of Education, Science and Technology of Esp\u00edrito Santo , Vila Velha, Esp\u00edrito Santo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian V","family":"Tose","sequence":"additional","affiliation":[{"name":"Petrole\u00f4mica and Forensic Laboratory, Chemistry Department, Federal University Esp\u00edrito Santo , Vit\u00f3ria, Esp\u00edrito Santo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola N S","family":"Fraz\u00e3o","sequence":"additional","affiliation":[{"name":"Scholarship Scientific Initiation PIBIC-CNPq\/UFMA, Federal University of Maranh\u00e3o , S\u00e3o Lu\u00eds, Maranh\u00e3o,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C\u00e9lia P","family":"Costa","sequence":"additional","affiliation":[{"name":"Center of Exact and Natural Sciences, Stadual University of Maranh\u00e3o , S\u00e3o Lu\u00eds, Maranh\u00e3o,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulcelena F","family":"Silva","sequence":"additional","affiliation":[{"name":"Morphology Department, Federal University of Maranh\u00e3o , S\u00e3o Lu\u00eds, 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