{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:23:17Z","timestamp":1782588197388,"version":"3.54.5"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004410","name":"The Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["112S017"],"award-info":[{"award-number":["112S017"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to develop lipid\u2013polyethylene glycol (PEG)\u2013polymer hybrid nanoparticles, which have high affinity to tumour tissue with active ingredient, a new generation antineoplastic drug, farnesylthiosalicylic acid (FTA) for treatment of glioblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Farnesylthiosalicylic acid-loaded poly(lactic-co-glycolic acid)-1,2 distearoyl-glycerol-3-phospho-ethanolamine-N [methoxy (PEG)-2000] ammonium salt (PLGA-DSPE-PEG) with or without 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) hybrid nanoparticles has been prepared and evaluated for in-vitro characterization. Cytotoxicity of FTA-loaded nanoparticles along with its efficacy on rat glioma-2 (RG2) cells was also evaluated both in vitro (in comparison with non-malignant cell line, L929) and in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key findings<\/jats:title><jats:p>Scanning electron microscopy studies showed that all formulations prepared had smooth surface and spherical in shape. FTA and FTA-loaded nanoparticles have cytotoxic activity against RG2 glioma cell lines in cell culture studies, which further increases with addition of DOTAP. Magnetic resonance imaging and histopathologic evaluation on RG2 tumour cells in rat glioma model (49 female Wistar rats, 250\u2013300 g) comparing intravenous and intratumoral injections of the drug have been performed and FTA-loaded nanoparticles reduced tumour size significantly in in-vivo studies, with higher efficiency of intratumoral administration than intravenous route.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Farnesylthiosalicylic acid-loaded PLGA-DSPE-PEG-DOTAP hybrid nanoparticles are proven to be effective against glioblastoma in both in-vitro and in-vivo experiments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphp.12740","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T09:58:42Z","timestamp":1493891922000},"page":"1010-1021","source":"Crossref","is-referenced-by-count":22,"title":["Farnesylthiosalicylic acid-loaded lipid\u2013polyethylene glycol\u2013polymer hybrid nanoparticles for treatment of glioblastoma"],"prefix":"10.1093","volume":"69","author":[{"given":"Abbas","family":"Kaffashi","sequence":"first","affiliation":[{"name":"Department of Nanotechnology and Nanomedicine, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"L\u00fcle","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences and Psychiatry, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5066-2772","authenticated-orcid":false,"given":"Sibel","family":"Bozda\u011f Pehlivan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Sar\u0131s\u00f6zen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130mran","family":"Vural","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcsn\u00fc","family":"Ko\u015fucu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taner","family":"Demir","sequence":"additional","affiliation":[{"name":"Bilkent University National Magnetic Resonance Research Center (UMRAM) , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir Emre","family":"Bu\u011fdayc\u0131","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University , Burdur,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"S\u00f6ylemezo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kader","family":"Karl\u0131 O\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Mut","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Hacettepe University , Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"2024103012564338800_jphp12740-cit-0001","volume-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004\u20132008"},{"issue":"Suppl 5","key":"2024103012564338800_jphp12740-cit-0002","doi-asserted-by":"crossref","first-page":"v190","DOI":"10.1093\/annonc\/mdq187","article-title":"High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"21","author":"Stupp","year":"2010","journal-title":"Ann Oncol"},{"key":"2024103012564338800_jphp12740-cit-0003","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neucir.2011.07.001","article-title":"[WHO grade II gliomas: review of the current management]","volume":"23","author":"Martino","year":"2012","journal-title":"Neurocirugia (Asturias, Spain)"},{"key":"2024103012564338800_jphp12740-cit-0004","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/CCO.0b013e32834ace58","article-title":"Surgery of malignant gliomas: advances and perspectives","volume":"23","author":"Carapella","year":"2011","journal-title":"Curr Opin Oncol"},{"key":"2024103012564338800_jphp12740-cit-0005","first-page":"1359","article-title":"Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma","volume":"17","author":"Yang","year":"2007","journal-title":"Oncol Rep"},{"key":"2024103012564338800_jphp12740-cit-0006","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1017\/S0317167100007265","article-title":"Adjuvant chemotherapy for adults with malignant glioma: a systematic review","volume":"34","author":"Perry","year":"2007","journal-title":"Can J Neurol Sci"},{"issue":"6 Suppl","key":"2024103012564338800_jphp12740-cit-0007","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1586\/14737175.5.6.S41","article-title":"Chemotherapy for malignant glioma","volume":"5","author":"Nicholas","year":"2005","journal-title":"Expert Rev Neurother"},{"key":"2024103012564338800_jphp12740-cit-0008","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1056\/NEJMra0708126","article-title":"Malignant gliomas in adults","volume":"359","author":"Wen","year":"2008","journal-title":"N Engl J Med"},{"key":"2024103012564338800_jphp12740-cit-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2009.09.001","article-title":"Biodegradable polymeric nanoparticles based drug delivery systems","volume":"75","author":"Kumari","year":"2010","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2024103012564338800_jphp12740-cit-0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/nn900002m","article-title":"Impact of nanotechnology on drug delivery","volume":"3","author":"Farokhzad","year":"2009","journal-title":"ACS Nano"},{"key":"2024103012564338800_jphp12740-cit-0011","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2217\/17435889.3.4.401","article-title":"Impact of nanoscience and nanotechnology on controlled drug delivery","volume":"3","author":"Youan","year":"2008","journal-title":"Nanomedicine"},{"key":"2024103012564338800_jphp12740-cit-0012","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1039\/C1CS15080D","article-title":"Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer","volume":"41","author":"Llevot","year":"2012","journal-title":"Chem Soc Rev"},{"key":"2024103012564338800_jphp12740-cit-0013","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.2174\/0929867311320170006","article-title":"Potential use of polymeric nanoparticles for drug delivery across the blood-brain barrier","volume":"20","author":"Tosi","year":"2013","journal-title":"Curr Med Chem"},{"key":"2024103012564338800_jphp12740-cit-0014","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1016\/j.biomaterials.2012.07.046","article-title":"Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles","volume":"33","author":"Xin","year":"2012","journal-title":"Biomaterials"},{"key":"2024103012564338800_jphp12740-cit-0015","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1208\/s12249-011-9695-x","article-title":"Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors","volume":"12","author":"Trapani","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"2024103012564338800_jphp12740-cit-0016","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2011.05.046","article-title":"Treatment of glioblastoma with poly(isohexyl cyanoacrylate) nanoparticles","volume":"415","author":"Wohlfart","year":"2011","journal-title":"Int J Pharm"},{"key":"2024103012564338800_jphp12740-cit-0017","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1002\/adma.201200653","article-title":"Hybrid nanoparticles for detection and treatment of cancer","volume":"24","author":"Sailor","year":"2012","journal-title":"Adv Mater"},{"key":"2024103012564338800_jphp12740-cit-0018","doi-asserted-by":"crossref","first-page":"e19121","DOI":"10.1371\/journal.pone.0019121","article-title":"Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers","volume":"6","author":"Wohlfart","year":"2011","journal-title":"PLoS One"},{"key":"2024103012564338800_jphp12740-cit-0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/02652049809006831","article-title":"Polymer-coated long-circulating microparticulate pharmaceuticals","volume":"15","author":"Torchilin","year":"1998","journal-title":"J Microencapsul"},{"key":"2024103012564338800_jphp12740-cit-0020","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0022-3565(24)35204-8","article-title":"Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier","volume":"291","author":"Fenart","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"2024103012564338800_jphp12740-cit-0021","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijpharm.2011.09.039","article-title":"Cationic ligand appended nanoconstructs: a prospective strategy for brain targeting","volume":"421","author":"Agarwal","year":"2011","journal-title":"Int J Pharm"},{"key":"2024103012564338800_jphp12740-cit-0022","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.biomaterials.2009.01.005","article-title":"Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups","volume":"30","author":"Salvador-Morales","year":"2009","journal-title":"Biomaterials"},{"key":"2024103012564338800_jphp12740-cit-0023","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0142-9612(92)90189-U","article-title":"Controlled cisplatin delivery system using poly(D, L-lactic acid)","volume":"13","author":"Ike","year":"1992","journal-title":"Biomaterials"},{"key":"2024103012564338800_jphp12740-cit-0024","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/1061186X.2010.504267","article-title":"The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats","volume":"19","author":"Zhao","year":"2011","journal-title":"J Drug Target"},{"key":"2024103012564338800_jphp12740-cit-0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","article-title":"Micellar nanocarriers: pharmaceutical perspectives","volume":"24","author":"Torchilin","year":"2007","journal-title":"Pharm Res"},{"key":"2024103012564338800_jphp12740-cit-0026","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ejpb.2011.11.008","article-title":"Physico-chemical characterisation of cationic DOTAP liposomes as drug delivery system for a hydrophilic decapeptide before and after freeze-drying","volume":"80","author":"Wieber","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012564338800_jphp12740-cit-0027","doi-asserted-by":"crossref","first-page":"11709","DOI":"10.1158\/0008-5472.CAN-06-1878","article-title":"A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration","volume":"66","author":"Goldberg","year":"2006","journal-title":"Can Res"},{"key":"2024103012564338800_jphp12740-cit-0028","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1158\/1535-7163.MCT-08-0488","article-title":"Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats","volume":"7","author":"Goldberg","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"2024103012564338800_jphp12740-cit-0029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1021\/jm801165r","article-title":"New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models","volume":"52","author":"Goldberg","year":"2009","journal-title":"J Med Chem"},{"key":"2024103012564338800_jphp12740-cit-0030","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/jps.2600700513","article-title":"High-pressure liquid chromatographic determination of ibuprofen in plasma","volume":"70","author":"Shimek","year":"1981","journal-title":"J Pharm Sci"},{"key":"2024103012564338800_jphp12740-cit-0031","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/la103576a","article-title":"Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method","volume":"26","author":"Fang","year":"2010","journal-title":"Langmuir"},{"key":"2024103012564338800_jphp12740-cit-0032","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.colsurfb.2007.08.011","article-title":"Preparation and characterization of PLGA particles for subcutaneous controlled drug release by membrane emulsification","volume":"61","author":"Gasparini","year":"2008","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2024103012564338800_jphp12740-cit-0033","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.nano.2009.11.004","article-title":"Singlet oxygen-induced apoptosis of cancer cells using upconversion fluorescent nanoparticles as a carrier of photosensitizer","volume":"6","author":"Guo","year":"2010","journal-title":"Nanomedicine"},{"key":"2024103012564338800_jphp12740-cit-0034","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1227\/01.NEU.0000245607.99946.8F","article-title":"Treatment of malignant gliomas with mitoxantrone-loaded poly (lactide-co-glycolide) microspheres","volume":"59","author":"Yemisci","year":"2006","journal-title":"Neurosurgery"},{"key":"2024103012564338800_jphp12740-cit-0035","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/neuonc\/noq023","article-title":"Regression of advanced rat and human gliomas by local or systemic treatment with oncolytic parvovirus H-1 in rat models","volume":"12","author":"Geletneky","year":"2010","journal-title":"Neuro Oncol"},{"key":"2024103012564338800_jphp12740-cit-0036","first-page":"1457","article-title":"Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging","volume":"3","author":"Chenevert","year":"1997","journal-title":"Clin Cancer Res"},{"key":"2024103012564338800_jphp12740-cit-0037","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jmri.24469","article-title":"Measurement of rat brain tumor kinetics using an intravascular MR contrast agent and DCE-MRI nested model selection","volume":"40","author":"Chwang","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"2024103012564338800_jphp12740-cit-0038","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1158\/0008-5472.CAN-03-3631","article-title":"Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging","volume":"64","author":"Saito","year":"2004","journal-title":"Can Res"},{"key":"2024103012564338800_jphp12740-cit-0039","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nec.2012.04.006","article-title":"Nanotechnology applications for glioblastoma","volume":"23","author":"Nduom","year":"2012","journal-title":"Neurosurg Clin N Am"},{"key":"2024103012564338800_jphp12740-cit-0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2217\/nnm.11.12","article-title":"Role of nanobiotechnology in the personalized management of glioblastoma multiforme","volume":"6","author":"Jain","year":"2011","journal-title":"Nanomedicine"},{"key":"2024103012564338800_jphp12740-cit-0041","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/03639045.2011.608191","article-title":"Nanostructure-based drug delivery systems for brain targeting","volume":"38","author":"Haque","year":"2012","journal-title":"Drug Dev Ind Pharm"},{"key":"2024103012564338800_jphp12740-cit-0042","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1423-0127-16-86","article-title":"Formulation of novel lipid-coated magnetic nanoparticles as the probe for in vivo imaging","volume":"16","author":"Huang","year":"2009","journal-title":"J Biomed Sci"},{"key":"2024103012564338800_jphp12740-cit-0043","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ijpharm.2012.03.047","article-title":"Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma","volume":"430","author":"Ling","year":"2012","journal-title":"Int J Pharm"},{"key":"2024103012564338800_jphp12740-cit-0044","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijpharm.2012.03.032","article-title":"Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway","volume":"430","author":"Martins","year":"2012","journal-title":"Int J Pharm"},{"key":"2024103012564338800_jphp12740-cit-0045","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3109\/10837450.2012.696267","article-title":"Effect of preparation conditions on the size and encapsulation properties of mPEG-PLGA nanoparticles simultaneously loaded with vincristine sulfate and curcumin","volume":"18","author":"Wang","year":"2013","journal-title":"Pharm Dev Technol"},{"key":"2024103012564338800_jphp12740-cit-0046","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.nimb.2005.06.065","article-title":"Drug loading to lipid-based cationic nanoparticles","volume":"238","author":"Cavalcanti","year":"2005","journal-title":"Nucl Instrum Methods Phys Res, Sect B"},{"key":"2024103012564338800_jphp12740-cit-0047","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0168-3659(02)00239-0","article-title":"Investigation of the factors influencing the release rates of cyclosporin A-loaded micro- and nanoparticles prepared by high-pressure homogenizer","volume":"84","author":"Lee","year":"2002","journal-title":"J Control Release"},{"key":"2024103012564338800_jphp12740-cit-0048","first-page":"1685","article-title":"Biological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA","volume":"6","author":"Nair","year":"2011","journal-title":"Int J Nanomedicine"},{"key":"2024103012564338800_jphp12740-cit-0049","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/sj.cdd.4401783","article-title":"Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells","volume":"13","author":"Amos","year":"2006","journal-title":"Cell Death Differ"},{"key":"2024103012564338800_jphp12740-cit-0050","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1529\/biophysj.106.096990","article-title":"Computational and analytical modeling of cationic lipid-DNA complexes","volume":"92","author":"Farago","year":"2007","journal-title":"Biophys J"},{"key":"2024103012564338800_jphp12740-cit-0051","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/0929867043456142","article-title":"Modeling of cationic lipid-DNA complexes","volume":"11","author":"May","year":"2004","journal-title":"Curr Med Chem"},{"key":"2024103012564338800_jphp12740-cit-0052","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jconrel.2008.05.027","article-title":"Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas","volume":"130","author":"Allard","year":"2008","journal-title":"J Control Release"},{"key":"2024103012564338800_jphp12740-cit-0053","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00146086","article-title":"Prognostic significance of preoperative MRI scans in glioblastoma multiforme","volume":"27","author":"Hammoud","year":"1996","journal-title":"J Neurooncol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/69\/8\/1010\/60231336\/jphp12740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/69\/8\/1010\/60231336\/jphp12740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:53:40Z","timestamp":1750222420000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/69\/8\/1010\/6127862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":53,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,1]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12740","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2017,8]]},"published":{"date-parts":[[2017,8,1]]}}}