{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:11:30Z","timestamp":1783030290003,"version":"3.54.6"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study was conducted to explore whether Hypericum perforatum L. (HPL) as a potent antioxidant protects against oxidative stress, cytokine production and caspase expression in muscle (soleus), brain and blood of sciatic nerve injury (SNI)-induced rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty-five rats were equally divided into five groups. The first and second were used as untreated control and sham control groups, respectively. The third, fourth and fifth were sham + HPL, SNI and SNI + HPL groups, respectively. The third and fifth groups received 30 mg\/kg HPL via gastric gavage for 28 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>High levels of muscle, brain and red blood cell (RBC) lipid peroxidation, plasma cytokine (TNF-\u03b1, IL-1\u03b2 and IL-2), muscle PARP, caspase 3 and 9 expression levels were decreased by HPL treatments. Plasma glutathione peroxidase (GPx) activity, \u03b1-tocopherol and melatonin, muscle, brain and RBC reduced glutathione (GSH) concentrations were decreased by SNI induction, whereas their values were increased by HPL treatments. \u03b2-carotene and retinol concentrations did not change in the five groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>HPL may play a role in preventing SNI-induced inflammatory, oxidative and apoptotic blood, muscle and brain damages through upregulation of the GSH and GPx values but downregulation of PARP, caspase level and cytokine production in SNI-induced rats.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12741","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T06:42:44Z","timestamp":1494916964000},"page":"83-92","source":"Crossref","is-referenced-by-count":24,"title":["<i>Hypericum perforatum<\/i> L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats"],"prefix":"10.1093","volume":"71","author":[{"given":"Fuat","family":"Uslusoy","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Faculty of Medical Faculty, Suleyman Demirel University , Isparta,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-6974","authenticated-orcid":false,"given":"Mustafa","family":"Naz\u0131ro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medical Faculty, Suleyman Demirel University , Isparta,","place":["Turkey"]},{"name":"Department of Neuroscience, Institute of Health Science, Suleyman Demirel University , Isparta,","place":["Turkey"]},{"name":"Neuroscience Research Center, Suleyman Demirel University , Isparta,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130shak Suat","family":"\u00d6vey","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medical Faculty, Suleyman Demirel University , Isparta,","place":["Turkey"]},{"name":"Department of Neuroscience, Institute of Health Science, Suleyman Demirel University , Isparta,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga Taha","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Faculty of Medical Faculty, Suleyman Demirel University , Isparta,","place":["Turkey"]},{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine, RWTH-Aachen , 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