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AAB rats were treated with TA (20 and 40 mg\/kg) or captoril.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key findings<\/jats:title><jats:p>Abdominal aortic banding rats that received TA showed ameliorated pathological changes in cardiac morphology and coefficients, decreased cardiac hypertrophy and apoptosis, a reduction in over expressions of angiotensin type 1 receptor (AT1R), angiotensin type 2 receptor (AT2R), phosphorylation of extracellular signal-regulated kinase 1\/2 (ERK1\/2) and transforming growth factor-\u03b2 (TGF-\u03b2) mRNA, and modified expression of matrix metal proteinase-9 (MMP-9) mRNA in AAB rat hearts. Furthermore, TA treatment contributed to a decrease in malondialdehyde (MDA) and endothelin-1 (ET-1) activities and content, while it caused an increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), nitric oxide (NO) and endothelial NO synthase (e-NOS). Furthermore, TA downregulated expression of tumour necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), bax, caspase-3 and upregulated expression of bcl-2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tannic acid displayed obvious suppression of AAB-induced cardiac hypertrophy in rats. The cardioprotective effects of TA may be attributed to multitargeted inhibition of oxidative stress, inflammation, fibrosis and apoptosis in addition to an increase in NO levels, decrease in ET-1 levels, and downregulation of angiotensin receptors and the phosphorylation of ERK1\/2.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphp.12763","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T11:14:37Z","timestamp":1497957277000},"page":"1191-1207","source":"Crossref","is-referenced-by-count":14,"title":["Protective effects of tannic acid on pressure overload-induced cardiac hypertrophy and underlying mechanisms in rats"],"prefix":"10.1093","volume":"69","author":[{"given":"Li","family":"Chu","sequence":"first","affiliation":[{"name":"Hebei Medical University , Shijiazhuang, Hebei,","place":["China"]},{"name":"Hebei University of Chinese Medicine , Shijiazhuang, 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