{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:22:48Z","timestamp":1787692968305,"version":"build-2784847793"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"ASTHI-Anabolic Skeletal Targets in Health and Illness","award":["BSC0201"],"award-info":[{"award-number":["BSC0201"]}]},{"name":"INDEPTH-Integrated NextGen Approaches in Disease and Environmental Toxicity","award":["BSC0111"],"award-info":[{"award-number":["BSC0111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study was undertaken to investigate the effects of a heartwood ethanolic extract (HEE) made from the Dalbergia sissoo on facture healing and in the prevention of pathological bone loss resulting from estrogen deficiency in ovariectomized (Ovx) rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Heartwood ethanolic extract (250, 500 and 1000 mg\/kg per day) was administered orally immediately next day after drill-hole injury and continued for 2 weeks. Ovx rats received HEE at same doses for 12 weeks and compared with 17-\u03b2 estradiol (E2; 100 \u03bcg\/kg for 5 days\/week subcutaneously) group. Confocal imaging for fracture healing, micro-architecture of long bones, biomechanical strength, formation of mineralized nodule by bone marrow osteoprogenitor cells, bone turnover markers and gene expression were studied. One-way ANOVA was used to test significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Heartwood ethanolic extract treatment promoted fracture healing, formation of new bone at the drill-hole site and stimulated osteogenic genes at callus region. HEE administration to the Ovx rats exhibited better micro-architectural parameters at various anatomical positions, better bone biomechanical strength and more osteoprogenitor cells in the bone marrow compared with Ovx + vehicle group. HEE exhibited no uterine estrogenicity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Oral administration of HEE was found to promote fracture healing and exhibited osteoprotective effect by possibly stimulation of osteoblast function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12764","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T05:42:46Z","timestamp":1498801366000},"page":"1381-1397","source":"Crossref","is-referenced-by-count":17,"title":["Heartwood extract from <i>Dalbergia sissoo<\/i> promotes fracture healing and its application in ovariectomy-induced osteoporotic rats"],"prefix":"10.1093","volume":"69","author":[{"given":"Anirudha","family":"Karvande","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Central Drug Research Institute (Council of Scientific and Industrial Research) , Lucknow, Uttar 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