{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:12:18Z","timestamp":1791475938995,"version":"4.3.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Ministry of Economics and Technology","award":["AZ V-630-F-157-2012\/230"],"award-info":[{"award-number":["AZ V-630-F-157-2012\/230"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this test series was to elucidate the importance of selecting the right media composition for a biopredictive in-vitro dissolution screening of enteric-coated dosage forms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Drug release from immediate-release (IR) and enteric-coated (EC) aspirin formulations was assessed in phosphate-based and bicarbonate-based media with different pH, electrolyte composition and ionic strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Drug release from aspirin IR tablets was unaffected by media composition. In contrast, drug release from EC aspirin formulations was affected by buffer species and ionic strength. In all media, drug release increased with increasing ionic strength, but in bicarbonate-based buffers was delayed when compared with that in phosphate-based buffers. Interestingly, the cation species in the dissolution medium had also a clear impact on drug release. Drug release profiles obtained in Blank CarbSIF, a new medium simulating pH and average ionic composition of small intestinal fluid, were different from those obtained in all other buffer compositions studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results from this study in which the impact of various media parameters on drug release of EC aspirin formulations was systematically screened clearly show that when developing predictive dissolution tests, it is important to simulate the ionic composition of intraluminal fluids as closely as possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.12777","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T08:25:01Z","timestamp":1499934301000},"page":"1327-1340","source":"Crossref","is-referenced-by-count":33,"title":["Assessing the influence of media composition and ionic strength on drug release from commercial immediate-release and enteric-coated aspirin tablets"],"prefix":"10.1093","volume":"69","author":[{"given":"Frank","family":"Karkossa","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport (C_DAT), University of Greifswald , Greifswald,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-5780","authenticated-orcid":false,"given":"Sandra","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport (C_DAT), University of Greifswald , Greifswald,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"key":"2024103012565476800_jphp12777-cit-0001","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0168-3659(02)00145-1","article-title":"Influence of chloride ion exchange on the permeability and drug release of Eudragit RS 30 D films","volume":"82","author":"Wagner","year":"2002","journal-title":"J Control Release"},{"key":"2024103012565476800_jphp12777-cit-0002","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0928-0987(96)00176-5","article-title":"Influence of buffer solution composition on drug release from pellets coated with neutral and quaternary acrylic polymers and on swelling of free polymer films","volume":"4","author":"Knop","year":"1996","journal-title":"Eur J Pharm Sci"},{"key":"2024103012565476800_jphp12777-cit-0003","doi-asserted-by":"crossref","first-page":"E668","DOI":"10.1208\/aapsj070367","article-title":"Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings","volume":"7","author":"Wagner","year":"2005","journal-title":"AAPS J"},{"key":"2024103012565476800_jphp12777-cit-0004","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1023\/A:1016021115481","article-title":"The influence of buffer species and strength on diltiazem HCl release from beads coated with the aqueous cationic polymer dispersions, Eudragit RS, RL 30D","volume":"13","author":"Bodmeier","year":"1996","journal-title":"Pharm Res"},{"key":"2024103012565476800_jphp12777-cit-0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1018910114436","article-title":"An organic acid-induced sigmoidal release system for oral controlled-release preparations","volume":"11","author":"Narisawa","year":"1994","journal-title":"Pharm Res"},{"key":"2024103012565476800_jphp12777-cit-0006","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1021\/js950180o","article-title":"An organic acid-induced sigmoidal release system for oral controlled-release preparations. 2. Permeability enhancement of Eudragit RS coating led by the physicochemical interactions with organic acid","volume":"85","author":"Narisawa","year":"1996","journal-title":"J Pharm Sci"},{"key":"2024103012565476800_jphp12777-cit-0007","first-page":"502","article-title":"Factors affecting the dissolution rate of enteric coatings","volume":"39","author":"Spitael","year":"1977","journal-title":"Pharm Ind"},{"key":"2024103012565476800_jphp12777-cit-0008","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0378-5173(93)90344-F","article-title":"An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting","volume":"91","author":"Ashford","year":"1993","journal-title":"Int J Pharm"},{"key":"2024103012565476800_jphp12777-cit-0009","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1023\/A:1016202814109","article-title":"Ionic strength dependence of dissolution for Eudragit S-100 coated pellets","volume":"12","author":"Kararli","year":"1995","journal-title":"Pharm Res"},{"key":"2024103012565476800_jphp12777-cit-0010","first-page":"1","article-title":"Deleterious effects of corticosteroids, acetylsalicylic acid, and other non steroidal antiinflammatory drugs on the gastroduodenal mucosa","volume":"43","author":"Borsch","year":"1984","journal-title":"Z Rheumatol"},{"key":"2024103012565476800_jphp12777-cit-0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2036.2005.02714.x","article-title":"Similarities and differences among delayed-release proton-pump inhibitor formulations","volume":"22","author":"Horn","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"2024103012565476800_jphp12777-cit-0012","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5173(88)90031-2","article-title":"Preformulation solubility and kinetic-studies of 2\u2032,3\u2032-dideoxypurine nucleosides \u2013 potential anti-AIDS agents","volume":"45","author":"Anderson","year":"1988","journal-title":"Int J Pharm"},{"key":"2024103012565476800_jphp12777-cit-0013","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.2042-7158.1984.tb04394.x","article-title":"Absorption of acetylsalicylic acid from enteric-coated tablets in relation to gastric-emptying and in vivo disintegration","volume":"36","author":"Bogentoft","year":"1984","journal-title":"J Pharm Pharmacol"},{"key":"2024103012565476800_jphp12777-cit-0014","first-page":"144","article-title":"The evaluation of an enteric-coated naproxen tablet formulation using gamma-scintigraphy","volume":"39","author":"Wilding","year":"1993","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012565476800_jphp12777-cit-0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/A:1018986827350","article-title":"An in vitro in vivo correlation for the disintegration and onset of drug release from enteric-coated pellets","volume":"10","author":"Ebel","year":"1993","journal-title":"Pharm Res"},{"key":"2024103012565476800_jphp12777-cit-0016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF03188829","article-title":"Contribution of scintigraphy to verify the reliability of different preparation processes for enteric-coated capsules","volume":"19","author":"Catteau","year":"1994","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"2024103012565476800_jphp12777-cit-0017","first-page":"463","article-title":"The in vivo behaviour of enteric naproxen tablets coated with an aqueous dispersion of methacrylic acid copolymer","volume":"7","author":"Lehmann","year":"1997","journal-title":"STP Pharma Sci"},{"key":"2024103012565476800_jphp12777-cit-0018","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5173(01)00871-7","article-title":"Enteric coated HPMC capsules designed to achieve intestinal targeting","volume":"231","author":"Cole","year":"2002","journal-title":"Int J Pharm"},{"key":"2024103012565476800_jphp12777-cit-0019","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2010.07.105","article-title":"A paradigm shift in enteric coating: achieving rapid release in the proximal small intestine of man","volume":"147","author":"Liu","year":"2010","journal-title":"J Control Release"},{"key":"2024103012565476800_jphp12777-cit-0020","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1161\/01.STR.0000231683.43347.ec","article-title":"Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers","volume":"37","author":"Cox","year":"2006","journal-title":"Stroke"},{"key":"2024103012565476800_jphp12777-cit-0021","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2165\/00003088-199121050-00006","article-title":"Bioinequivalence of four 100 mg oral aspirin formulations in healthy volunteers","volume":"21","author":"Bochner","year":"1991","journal-title":"Clin Pharmacokinet"},{"key":"2024103012565476800_jphp12777-cit-0022","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1773-2247(05)50049-2","article-title":"Dissolution of pH responsive formulations in media resembling intestinal fluids: bicarbonate versus phosphate buffers","volume":"15","author":"Fadda","year":"2005","journal-title":"J Drug Deliv Sci Technol"},{"key":"2024103012565476800_jphp12777-cit-0023","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijpharm.2005.10.038","article-title":"A comparative in vitro assessment of the drug release performance of pH-responsive polymers for ileo-colonic delivery","volume":"308","author":"Ibekwe","year":"2006","journal-title":"Int J Pharm"},{"key":"2024103012565476800_jphp12777-cit-0024","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1021\/acs.molpharmaceut.6b00077","article-title":"Toward biopredictive dissolution for enteric coated dosage forms","volume":"13","author":"Al-Gousous","year":"2016","journal-title":"Mol Pharm"},{"key":"2024103012565476800_jphp12777-cit-0025","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0032-5910(01)00401-6","article-title":"Comparison of the release profiles of a water soluble drug carried by Eudragit-coated capsules in different in-vitro dissolution liquids","volume":"119","author":"Chan","year":"2001","journal-title":"Powder Technol"},{"key":"2024103012565476800_jphp12777-cit-0026","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejps.2013.09.020","article-title":"A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds","volume":"51","author":"Garbacz","year":"2014","journal-title":"Eur J Pharm Sci"},{"key":"2024103012565476800_jphp12777-cit-0027","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijpharm.2014.04.019","article-title":"Accelerating the dissolution of enteric coatings in the upper small intestine: evolution of a novel pH 5.6 bicarbonate buffer system to assess drug release","volume":"468","author":"Varum","year":"2014","journal-title":"Int J Pharm"},{"key":"2024103012565476800_jphp12777-cit-0028","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1211\/jpp.59.10.0007","article-title":"Is bicarbonate buffer suitable as a dissolution medium?","volume":"59","author":"Boni","year":"2007","journal-title":"J Pharm Pharmacol"},{"key":"2024103012565476800_jphp12777-cit-0029","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1208\/s12249-013-9933-5","article-title":"An automated system for monitoring and regulating the pH of bicarbonate buffers","volume":"14","author":"Garbacz","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"2024103012565476800_jphp12777-cit-0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1023\/A:1012107801889","article-title":"Characterization of fluids from the stomach and proximal jejunum in men and women","volume":"14","author":"Lindahl","year":"1997","journal-title":"Pharm Res"},{"key":"2024103012565476800_jphp12777-cit-0031","volume-title":"Physiology of the Digestive Tract","author":"Davenport","year":"1984"},{"key":"2024103012565476800_jphp12777-cit-0032","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI106561","article-title":"Acute undifferentiated human diarrhea in the tropics. II. Alterations in intestinal fluid and electrolyte movements","volume":"50","author":"Banwell","year":"1971","journal-title":"J Clin Invest"},{"key":"2024103012565476800_jphp12777-cit-0033","first-page":"733","article-title":"The contribution of the colon to electrolyte and water conservation in man","volume":"81","author":"Phillips","year":"1973","journal-title":"J Lab Clin Med"},{"key":"2024103012565476800_jphp12777-cit-0034","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0016-5107(04)01809-7","article-title":"Electrolyte composition of endoscopically collected duodenal drainage fluid after synthetic porcine secretin stimulation in healthy subjects","volume":"60","author":"Stevens","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"2024103012565476800_jphp12777-cit-0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1208\/s12249-016-0671-3","article-title":"Simulating different dosing scenarios for a child-appropriate valproate ER formulation in a new pediatric two-stage dissolution model","volume":"18","author":"Karkossa","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"2024103012565476800_jphp12777-cit-0036","first-page":"115","article-title":"Ein einfaches Verfahren zur Ermittlung von in vitro-\/in vivo-Zusammenh\u00e4ngen in der Galenik","volume":"27","author":"Voegele","year":"1981","journal-title":"Act Pharm Technol"},{"key":"2024103012565476800_jphp12777-cit-0037","volume-title":"Eudragit Brochure","author":"Evonik Industries","year":"2017"},{"key":"2024103012565476800_jphp12777-cit-0038","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1002\/jps.23212","article-title":"Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid","volume":"101","author":"Dressman","year":"2012","journal-title":"J Pharm Sci"},{"key":"2024103012565476800_jphp12777-cit-0039","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/jps.2600610906","article-title":"Dissolution of aspirin from tablets containing various buffering agents","volume":"61","author":"Javaid","year":"1972","journal-title":"J Pharm Sci"},{"key":"2024103012565476800_jphp12777-cit-0040","volume-title":"USP 39\/NF 34","author":"USP","year":"2016"},{"key":"2024103012565476800_jphp12777-cit-0041","volume-title":"European Pharmacopoeia","author":"PhEur","year":"2017","edition":"9th edn."},{"key":"2024103012565476800_jphp12777-cit-0042","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/aic.10329","article-title":"Facilitated diffusion in the dissolution of carboxylic polymers","volume":"51","author":"Nguyen","year":"2005","journal-title":"AIChE J"},{"key":"2024103012565476800_jphp12777-cit-0043","volume-title":"Freisetzung aus magensaftresistent \u00fcberzogenen Arzneiformen (Drug Release from Enteric Coated Dosage Forms)","author":"Schmidt-Mende","year":"2001"},{"key":"2024103012565476800_jphp12777-cit-0044","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/jphp.12540","article-title":"Use of bicarbonate buffer systems for dissolution characterization of enteric-coated proton pump inhibitor tablets","volume":"68","author":"Shibata","year":"2016","journal-title":"J Pharm Pharmacol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/69\/10\/1327\/60231533\/jphp12777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/69\/10\/1327\/60231533\/jphp12777.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T14:28:55Z","timestamp":1730298535000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/69\/10\/1327\/6127869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,1]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12777","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,10,1]]}}}