{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:37:48Z","timestamp":1778575068515,"version":"3.51.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Deanship of Scientific Research and Research Center"},{"DOI":"10.13039\/100008901","name":"College of Pharmacy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The solubility of an herbal compound ferulic acid (FA) in various (isopropanol (IPA) + water) mixtures was measured and correlated at temperatures \u2018T = 298.2 K to 318.2 K\u2019 and pressure \u2018p = 0.1 MPa\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The experimental solubilities of FA in mole fraction were determined using a static equilibrium method and correlated with \u2018Apelblat, Van't Hoff, Yalkowsky and Jouyban\u2013Acree models\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The maximum mole fraction solubilities of FA were obtained in neat IPA (2.58 \u00d7 10\u22122 at T = 318.2 K) followed by minimum in neat water (4.87 \u00d7 10\u22125 at T = 298.2 K). The activity coefficients of FA in various (IPA + water) mixtures were determined to evaluate the molecular interactions between FA and co solvent mixtures. Strong molecular interactions were seen between FA and neat IPA in comparison with FA and neat water. \u2018Apparent thermodynamic analysis\u2019 indicated an \u2018endothermic and entropy-driven dissolution\u2019 of FA in all (IPA + water) mixtures evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Isopropanol was investigated as a good cosolvent in the solubility enhancement of FA in water; therefore, it could be used as solubilizer in solubility enhancement and formulation development of FA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12786","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T12:14:46Z","timestamp":1500466486000},"page":"1485-1494","source":"Crossref","is-referenced-by-count":20,"title":["Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures"],"prefix":"10.1093","volume":"69","author":[{"given":"Nazrul","family":"Haq","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University , Riyadh,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasir A","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University , Riyadh,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-0885","authenticated-orcid":false,"given":"Faiyaz","family":"Shakeel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University , Riyadh,","place":["Saudi 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