{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:40:09Z","timestamp":1750815609942,"version":"3.41.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"publisher","award":["93-02-30-25784"],"award-info":[{"award-number":["93-02-30-25784"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Alpha7 nicotinic acetylcholine receptor (\u03b17-nAChR), an emerging pharmacological target for a variety of medical conditions, is expressed in the most mammalian tissues with different effects. So, this study was designed to investigate the expression, localization and effect of \u03b17-nAChR in rat corpus cavernosum (CC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Key findings<\/jats:title><jats:p>Reverse transcription polymerase chain reaction (RT-PCR) revealed that \u03b17-nAChR was expressed in rat CC and double immunofluorescence studies demonstrated the presence of \u03b17-nAChR in corporal neurons. The rat CC segments were mounted in organ bath chambers and contracted with phenylephrine (0.1 \u03bcm -300 \u03bcm) to investigate the relaxation effect of electrical field stimulation (EFS,10 Hz) assessed in the presence of guanethidine (adrenergic blocker, 5 \u03bcm) and atropine (muscarinic cholinergic blocker, 1 \u03bcm) to obtain non-adrenergic non-cholinergic (NANC) response. Cumulative administration of nicotine significantly potentiated the EFS-induced NANC relaxation (-log EC50 = 7.5 \u00b1 0.057). Whereas, the potentiated NANC relaxation of nicotine was significantly inhibited with different concentrations of methyllycaconitine citrate (\u03b17-nAChR antagonist, P &amp;lt; 0.05) in preincubated strips. L-NAME (non-specific nitric oxide synthase inhibitor, 1 \u03bcm) completely blocked the neurogenic relaxation induced by EFS plus nicotine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To conclude \u03b17-nAChR is expressed in rat CC and modulates the neurogenic relaxation response to nicotine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphp.12806","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T07:42:48Z","timestamp":1503560568000},"page":"1754-1761","source":"Crossref","is-referenced-by-count":5,"title":["The expression, localization and function of \u03b17 nicotinic acetylcholine receptor in rat corpus cavernosum"],"prefix":"10.1093","volume":"69","author":[{"given":"Hedyeh","family":"Faghir-Ghanesefat","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences , Tehran,","place":["Iran"]},{"name":"Experimental Medicine Research Center, Tehran 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