{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:43:28Z","timestamp":1789785808306,"version":"4.0.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006284","name":"Universidad Nacional del Centro de la Provincia de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006284","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009082","name":"Universidad Cat\u00f3lica de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006048","name":"Universidad de la Rep\u00fablica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010442","name":"Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010442","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CIVETAN in the processing of HPLC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Here, we aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In the pharmacokinetic study, ABZ self-dispersible nanocrystals (SDNCS) and a control formulation were administered orally to healthy dogs (n = 6). The concentrations of the sulphoxide metabolite in plasma were determined by high-performance liquid chromatography. For the anthelmintic efficacy trial, SDNCS and a commercially available formulation of ABZ were given to naturally parasitised dogs. The number of Ancylostoma caninum eggs in the faeces was determined using the McMaster technique.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The area under the curve, Tmax and Cmax for the SDNCS were improved compared to the control. The efficacy study showed no statistical differences between the SDNCS and the commercial formulation at the doses of 25 and 12.5 mg\/kg. However, significant differences (P &amp;lt; 0.05) between the treatments were found at 6.25 mg\/kg (a quarter of the reference dose) with a reduction in the faecal nematode egg counts of 62.0 \u00b1 21.1% and 100 \u00b1 0% for the control and SDNCS, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The improved pharmacokinetic performance observed for the novel formulation of ABZ correlated with an improved in vivo therapeutic response against a model intestinal nematode parasite in dogs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12834","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T09:56:42Z","timestamp":1508147802000},"page":"51-58","source":"Crossref","is-referenced-by-count":27,"title":["A nanocrystal-based formulation improves the pharmacokinetic performance and therapeutic response of albendazole in dogs"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-8972","authenticated-orcid":false,"given":"Alejandro Javier","family":"Paredes","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA), CONICET and Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria , C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Litterio","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda y Toxicolog\u00eda, Facultad de Ciencias Agropecuarias, Universidad Cat\u00f3lica de C\u00f3rdoba \u2013 Unidad Ejecutora IRNASUS, UCC-CONICET , C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Dib","sequence":"additional","affiliation":[{"name":"\u00c1rea Farmacolog\u00eda, Facultad de Veterinaria, Universidad de la Rep\u00fablica , Montevideo,","place":["Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Alberto","family":"Allemandi","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA), CONICET and Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria , C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lanusse","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Facultad de Ciencias Veterinarias, UNCPBA , Tandil,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio S\u00e1nchez","family":"Bruni","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Facultad de Ciencias Veterinarias, UNCPBA , Tandil,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago Daniel","family":"Palma","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA), CONICET and Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria , C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2024103012305856100_jphp12834-cit-0001","first-page":"422","volume-title":"Georgis\u2019 Parasitology for Veterinarians","author":"Bowman","year":"2003","edition":"8th"},{"key":"2024103012305856100_jphp12834-cit-0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0001-706X(96)00016-2","article-title":"Human enteric infection with Ancylostoma caninum: hookworms reappraised in the light of a \u2018\u2018new\u2019\u2019 zoonosis","volume":"62","author":"Prociv","year":"1996","journal-title":"Acta Trop"},{"key":"2024103012305856100_jphp12834-cit-0003","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.vetpar.2006.08.036","article-title":"High-level pyrantel resistance in the hookworm Ancylostoma caninum","volume":"143","author":"Kopp","year":"2007","journal-title":"Vet Parasitol"},{"key":"2024103012305856100_jphp12834-cit-0004","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0169-4758(90)90227-U","article-title":"Mode of action of benzimidazoles","volume":"6","author":"Lacey","year":"1990","journal-title":"Parasitol Today"},{"key":"2024103012305856100_jphp12834-cit-0005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.vetpar.2014.01.027","article-title":"Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis","volume":"203","author":"Pensel","year":"2014","journal-title":"Vet Parasitol"},{"key":"2024103012305856100_jphp12834-cit-0006","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.2042-7158.1998.tb03303.x","article-title":"Absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide","volume":"50","author":"Jung","year":"1998","journal-title":"J Pharm Pharmacol"},{"key":"2024103012305856100_jphp12834-cit-0007","doi-asserted-by":"crossref","first-page":"e0003950","DOI":"10.1371\/journal.pntd.0003950","article-title":"Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice","volume":"9","author":"Abulaihaiti","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"2024103012305856100_jphp12834-cit-0008","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0001-706X(02)00096-7","article-title":"Albendazole\u2013soybean oil emulsion for the treatment of human cystic echinococcosis: Evaluation of bioavailability and bioequivalence","volume":"83","author":"Mingjie","year":"2002","journal-title":"Acta Trop"},{"key":"2024103012305856100_jphp12834-cit-0009","article-title":"Albendazole Microcrystal Formulations Based on Chitosan and Cellulose Derivatives : physicochemical Characterization and In Vitro Parasiticidal Activity in Trichinella spiralis Adult Worms","author":"Priotti","year":"2016","journal-title":"AAPS PharmSciTech"},{"key":"2024103012305856100_jphp12834-cit-0010","first-page":"1","article-title":"Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions","volume":"18","author":"Castro","year":"2012","journal-title":"Pharm Dev Technol"},{"key":"2024103012305856100_jphp12834-cit-0011","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1017\/S003118200006635X","article-title":"Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine","volume":"113","author":"Wen","year":"1996","journal-title":"Parasitol"},{"key":"2024103012305856100_jphp12834-cit-0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actatropica.2009.09.006","article-title":"Two novel ternary albendazole \u2013 cyclodextrin \u2013 polymer systems : dissolution, bioavailability and efficacy against Taenia crassiceps cysts","volume":"113","author":"Palomares-alonso","year":"2010","journal-title":"Acta Trop"},{"key":"2024103012305856100_jphp12834-cit-0013","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ejpb.2007.05.009","article-title":"Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients","volume":"68","author":"Vogt","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012305856100_jphp12834-cit-0014","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0001-706X(02)00027-X","article-title":"Augmented bioavailability and cysticidal activity of albendazole reformulated in soybean emulsion in mice infected with Echinococcus granulosus or Echinococcus multilocularis","volume":"82","author":"Shuhua","year":"2002","journal-title":"Acta Trop"},{"key":"2024103012305856100_jphp12834-cit-0015","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00436-008-0980-x","article-title":"Albendazole treatment in cystic echinococcosis: pharmacokinetics and clinical efficacy of two different aqueous formulations","volume":"103","author":"Ceballos","year":"2008","journal-title":"Parasitol Res"},{"key":"2024103012305856100_jphp12834-cit-0016","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.parint.2004.05.001","article-title":"Effect of treatment with free and liposomized albendazole on selected immunological parameters and cyst growth in mice infected with Echinococcus multilocularis","volume":"53","author":"Velebny","year":"2004","journal-title":"Parasitol Int"},{"key":"2024103012305856100_jphp12834-cit-0017","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejpb.2005.05.009","article-title":"Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation","volume":"62","author":"Keck","year":"2006","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012305856100_jphp12834-cit-0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2011.01.007","article-title":"State of the art of nanocrystals \u2013 Special features, production, nanotoxicology aspects and intracellular delivery","volume":"78","author":"M\u00fcller","year":"2011","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012305856100_jphp12834-cit-0019","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2010.07.044","article-title":"Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives","volume":"399","author":"Shegokar","year":"2010","journal-title":"Int J Pharm"},{"key":"2024103012305856100_jphp12834-cit-0020","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3109\/03639045.2016.1151036","article-title":"Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying","volume":"42","author":"Paredes","year":"2016","journal-title":"Drug Dev Ind Pharm"},{"key":"2024103012305856100_jphp12834-cit-0021","first-page":"920305","article-title":"Comparative plasma exposure of albendazole after administration of rapidly disintegrating tablets in dogs","author":"Castro","year":"2013","journal-title":"Biomed Res Int"},{"key":"2024103012305856100_jphp12834-cit-0022","doi-asserted-by":"crossref","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"2024103012305856100_jphp12834-cit-0023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5694\/j.1326-5377.1921.tb60654.x","article-title":"Simple Levitation Method for the Detection of Hookworm Ova","volume":"2","author":"Willis","year":"1921","journal-title":"Med J Aust"},{"key":"2024103012305856100_jphp12834-cit-0024","volume-title":"Diagnosing helminthiasis through coprological examination","author":"Thienpont","year":"1986"},{"key":"2024103012305856100_jphp12834-cit-0025","first-page":"11","article-title":"Antiparasitic efficacy of a Ricobendazole controlled release formulation against Ancylostoma caninum and Trichuris sp intended for oral administration in dogs","volume":"52","author":"Dib","year":"2016","journal-title":"Veterinaria (Montevideo)"},{"key":"2024103012305856100_jphp12834-cit-0026","volume-title":"InfoStat version 24\u201303-2016","author":"Di Rienzo","year":"2016"},{"key":"2024103012305856100_jphp12834-cit-0027","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jconrel.2012.03.013","article-title":"Drug nanocrystals: in vivo performances","volume":"160","author":"Gao","year":"2012","journal-title":"J Control Release"},{"key":"2024103012305856100_jphp12834-cit-0028","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijpharm.2008.11.029","article-title":"Development of an oral rutin nanocrystal formulation","volume":"370","author":"Mauludin","year":"2009","journal-title":"Int J Pharm"},{"key":"2024103012305856100_jphp12834-cit-0029","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1053\/tvjl.2000.0484","article-title":"Comparative Availability of Two Oral Dosage Forms of Albendazole in Dogs","volume":"160","author":"S\u00e1nchez","year":"2000","journal-title":"Vet J"},{"key":"2024103012305856100_jphp12834-cit-0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2885.2006.00806.x","article-title":"Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals","volume":"29","author":"Jones","year":"2006","journal-title":"J Vet Pharmacol Ther"},{"key":"2024103012305856100_jphp12834-cit-0031","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-2885.2010.01203.x","article-title":"Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs","volume":"34","author":"Dib","year":"2011","journal-title":"J Vet Pharmacol Ther"},{"key":"2024103012305856100_jphp12834-cit-0032","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2307\/3275030","article-title":"Effects of crowding and of superinfection on habitat selection and egg production in Ancylostoma caninum","volume":"47","author":"Krupp","year":"1961","journal-title":"J Parasitol"},{"key":"2024103012305856100_jphp12834-cit-0033","first-page":"658","article-title":"The effect of age and size of infection on the egg production of the dog hookworm, Ancylostoma caninum","volume":"10","author":"Sarles","year":"1929","journal-title":"Am J Hyg"},{"key":"2024103012305856100_jphp12834-cit-0034","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.vetpar.2007.12.020","article-title":"Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum","volume":"152","author":"Kopp","year":"2008","journal-title":"Vet Parasitol"},{"key":"2024103012305856100_jphp12834-cit-0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0001-706X(03)00031-7","article-title":"Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics","volume":"86","author":"Dayan","year":"2003","journal-title":"Acta Trop"},{"key":"2024103012305856100_jphp12834-cit-0036","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.2460\/javma.1997.210.12.1753","article-title":"Development of bone marrow toxicosis after albendazole administration in a dog and cat","volume":"210","author":"Stokol","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"2024103012305856100_jphp12834-cit-0037","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2460\/javma.1998.213.01.44","article-title":"Adverse Events Associated With Albendazole and Other Products Used for Treatment of Giardiasis in Dogs","volume":"213","author":"Meyer","year":"1998","journal-title":"J Am Vet Med Assoc"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/70\/1\/51\/60223148\/jphp12834.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/70\/1\/51\/60223148\/jphp12834.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:36:09Z","timestamp":1730309769000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/70\/1\/51\/6121759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,1]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12834","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2018,1,1]]}}}