{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:15:24Z","timestamp":1790108124942,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT & Future Planning","doi-asserted-by":"publisher","award":["2015R1C1A1A02037383"],"award-info":[{"award-number":["2015R1C1A1A02037383"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Richwood Pharmaceutical Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study demonstrates the biological and chemical analysis of the mushroom Armillariella tabescens (Scop.) Sing. (Tricholomataceae).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Chemical structures of the isolates were determined by 1D and 2D NMR, and ESI-MS, as well as comparison with previously reported data. All isolates were tested for anti-inflammatory effects based on their ability to inhibit LPS-stimulated nitric oxide (NO) production in RAW264.7 cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>We found that the MeOH extract of the fruiting bodies of A. tabescens showed antigastritis activity against ethanol-induced gastric damage in rats and notably reduced the gastric damage index compared to control in a concentration-dependent manner. Chemical investigation of the MeOH extract led to the isolation of four steroids (1\u20134), three alkaloids (5\u20137), two nucleic acids (8\u20139) and four fatty acids (10\u201313). This is the first study to report the identification of all isolates, except for compound 7, from A. tabescens. Compounds 1, 2, 3, 4 and 10 showed inhibition on LPS-stimulated NO production. Treatment with compound 10 inhibited expression of iNOS, COX-2, phospho-IKK\u03b1, IKK\u03b1, phospho-I\u03baB\u03b1, I\u03baB\u03b1 and NF-kappa B in LPS-stimulated RAW264.7 cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Compound 10 likely contributes to the health benefits of A. tabescens as an antigastritis agent through its anti-inflammatory effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12871","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:15:14Z","timestamp":1516634114000},"page":"404-412","source":"Crossref","is-referenced-by-count":15,"title":["Antigastritis effects of <i>Armillariella tabescens<\/i> (Scop.) Sing. and the identification of its anti-inflammatory metabolites"],"prefix":"10.1093","volume":"70","author":[{"given":"Seulah","family":"Lee","sequence":"first","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University , Suwon,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahae","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University , Suwon,","place":["Korea"]},{"name":"College of Korean Medicine, Gachon University , Seongnam,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Gachon University , Seongnam,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonja","family":"Seok","sequence":"additional","affiliation":[{"name":"Agricultural Microbiology Division, National Institute of Agricultural Sciences, RDA , Iseo-myeon, Wanju-gun, Jeollabuk-do,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Su","family":"Jang","sequence":"additional","affiliation":[{"name":"Institute of Green Bio Science & Technology, Seoul National University , Pyeong Chang,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Bong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Yale University , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hee","family":"Shim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Duksung Women's University , Dobong-gu, Seoul,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-5244","authenticated-orcid":false,"given":"Ki Sung","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Gachon University , Seongnam,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-9138","authenticated-orcid":false,"given":"Ki Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University , Suwon,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"2024103012325275700_jphp12871-cit-0001","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/acs.jafc.6b00176","article-title":"Chemical constituents and their bioactivities of mushroom Phellinus rhabarbarinus","volume":"64","author":"Feng","year":"2016","journal-title":"J Agric Food Chem"},{"key":"2024103012325275700_jphp12871-cit-0002","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ijbiomac.2014.12.044","article-title":"Characterization of two water-soluble lignin metabolites with antiproliferative 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