{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:33:19Z","timestamp":1777566799552,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760668"],"award-info":[{"award-number":["81760668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460564"],"award-info":[{"award-number":["81460564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360658"],"award-info":[{"award-number":["81360658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260497"],"award-info":[{"award-number":["81260497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Department of the Jilin Province Scientific Research Fund Project","award":["20140311042YY"],"award-info":[{"award-number":["20140311042YY"]}]},{"name":"Innovative Research Team and Outstanding young talent cultivation fund project of Key Laboratory at Yanbian University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In alcoholic liver disease, alcohol and lipopolysaccharide (LPS) are major stimulation factors of hepatic lipogenesis. Our objective was to determine the protective mechanism of acanthoic acid (AA) in EtOH- and LPS-induced hepatic lipogenesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>HSC-T6 cells were treated with ethanol (200 mm) plus LPS (1 \u03bcg\/ml) for 1 h, followed by AA (10 or 20 \u03bcm) for another 6 h. C57BL\/6 mice were pretreated with of AA (20 and 40 mg\/kg) or equal volume of saline and then exposed to three doses of ethanol (5 g\/kg body weight) within 24 h. The mice were sacrificed at 6 h after the last ethanol dosing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Acanthoic acid significantly decreased the expressions of \u03b1-SMA, collagen-I, SREBP-1, and lipin1\/2 induced, also decreased fat droplets caused by EtOH\/LPS. AA treatment decreased the protein expressions of TLR4, CD14, IRAK4, TRAF3, p-TAK1 and NF-\u03baB increased by EtOH\/LPS on HSC cells. Results in vivo were consistent with results in vitro.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data demonstrated that AA might modulate hepatic fibrosis and lipid deposition in HSC-T6 cell stimulated with ethanol combined with LPS by decreasing lipin1\/2 via TLR4 and IRAK4 signalling pathways, and AA might be considered as a potential therapeutic candidate for alcoholic liver disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12877","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T06:46:23Z","timestamp":1516171583000},"page":"393-403","source":"Crossref","is-referenced-by-count":20,"title":["Acanthoic acid suppresses lipin1\/2 via TLR4 and IRAK4 signalling pathways in EtOH- and lipopolysaccharide-induced hepatic lipogenesis"],"prefix":"10.1093","volume":"70","author":[{"given":"Jian","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University , Yanji, Jilin Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University , Yanji, Jilin Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Li","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University , Yanji, Jilin Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University , Yanji, Jilin Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University , Yanji, Jilin Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Yang","family":"Shao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University , Yanji, Jilin 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