{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:09:58Z","timestamp":1771636198296,"version":"3.50.1"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006702","name":"UERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the anti-inflammatory potential of Pterodon polygalaeflorus hexane extract (HE) and its fractions on macrophage migration in vitro and in vivo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Hexane extract from P. polygalaeflorus fruits was fractionated and yielded four fractions. RAW 264.7 cells were treated with samples to evaluate cell viability (MTT assay), cell migration (wound healing and transwell assays), CD14 expression (flow cytometry), iNOS and cytokine mRNA expression (RT-qPCR), NO (Griess reaction) and cytokine (ELISA) production. In vivo migration was evaluated on the thioglycollate-induced peritonitis model. Qualitative analysis was performed by GC-MS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>All fractions inhibited the NO production by LPS-stimulated RAW 264.7 cells. Fr3 and Fr4 presented the lowest IC50 values. The expressions of iNOS and IL-1\u03b2, TNF-\u03b1 and IL-10 cytokines were inhibited by Fr3 and Fr4, whereas the CD14 expression was only inhibited by Fr3. All the samples inhibited RAW 264.7 migration in the wound healing and transwell assays. Fr3 and Fr4 reduced the migration of Mac-1+Gr-1\u2212 cells to the peritoneum and presented in their compositions: 6\u03b1-hydroxy-7\u03b2-acetoxyvouacapan-17\u03b2-oate, methyl 6\u03b1,7\u03b2-dihydroxyvouacapan-17\u03b2-oate, methyl 6\u03b1-acetoxy-7\u03b2-hydroxyvouacapan-17\u03b2-oate, geranylgeraniol and 14,15-epoxy-geranylgeraniol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The anti-inflammatory effects of Fr3 and Fr4 involve inhibition of cell migration, iNOS expression and NO production, cytokine expression (mRNA and proteins) and CD14 expression (Fr3).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12889","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T09:24:35Z","timestamp":1520414675000},"page":"808-820","source":"Crossref","is-referenced-by-count":9,"title":["Anti-inflammatory effect of diterpenes-enriched fractions from <i>Pterodon polygalaeflorus<\/i> through inhibition of macrophage migration and cytokine production"],"prefix":"10.1093","volume":"70","author":[{"given":"Nathalia Regina F","family":"Leal","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Vieira","family":"Vigliano","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana A","family":"Pinto","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayane V","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leosvaldo S M","family":"Velozo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia C C","family":"Sabino","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria da Gra\u00e7a","family":"Justo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-7415","authenticated-orcid":false,"given":"Marsen Garcia Pinto","family":"Coelho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro , Rio de Janeiro,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"2024103012324119400_jphp12889-cit-0001","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2024103012324119400_jphp12889-cit-0002","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/cs1040027","article-title":"The inflammatory macrophage: a story of Jekyll and Hyde","volume":"104","author":"Duffield","year":"2003","journal-title":"Clin Sci"},{"key":"2024103012324119400_jphp12889-cit-0003","first-page":"457","article-title":"The dual roles of neutrophils and macrophages in inflammation: a critical balance between tissue damage and repair","volume":"41","author":"","year":"2006","journal-title":"J Athl Train"},{"key":"2024103012324119400_jphp12889-cit-0004","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1568010054022024","article-title":"Macrophages in inflammation","volume":"4","author":"Fujiwara","year":"2005","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"2024103012324119400_jphp12889-cit-0005","first-page":"52","article-title":"Macrophages in synovial inflammation","volume":"4","author":"Kennedy","year":"2011","journal-title":"Front Imumunol"},{"key":"2024103012324119400_jphp12889-cit-0006","first-page":"1","article-title":"Anti-inflammatory activity of plants","volume":"3","author":"Okoli","year":"2003","journal-title":"J Nat Rem"},{"key":"2024103012324119400_jphp12889-cit-0007","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1189\/jlb.1010550","article-title":"Nitric oxide and redox mechanisms in the immune response","volume":"89","author":"Wink","year":"2011","journal-title":"J Leuk Biol"},{"key":"2024103012324119400_jphp12889-cit-0008","first-page":"222","volume-title":"Notas de Fitoterapia. Cat\u00e1logo dos dados principais sobre plantas utilizadas em medicina e farm\u00e1cia","author":"Coimbra","year":"1942"},{"key":"2024103012324119400_jphp12889-cit-0009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/S0103-50532000000200015","article-title":"Further diterpenoids isolated from Pterodon polygalaeflorus","volume":"11","author":"Arriaga","year":"2000","journal-title":"J Braz Chem Soc"},{"key":"2024103012324119400_jphp12889-cit-0010","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1590\/S0102-695X2008000300023","article-title":"Survey of medicinal plants used in the region Northeast of Brazil","volume":"18","author":"Agra","year":"2008","journal-title":"Rev Bras Farmacogn"},{"key":"2024103012324119400_jphp12889-cit-0011","doi-asserted-by":"crossref","first-page":"379459","DOI":"10.1155\/2015\/379459","article-title":"Sucupira as a potential plant for arthritis treatment and other diseases","volume":"2015","author":"Hoscheid","year":"2015","journal-title":"Arthritis"},{"key":"2024103012324119400_jphp12889-cit-0012","first-page":"779","volume-title":"Livro verde das plantas Medicinais e industriais do Brasil","author":"Cruz","year":"1965"},{"key":"2024103012324119400_jphp12889-cit-0013","first-page":"97","article-title":"Two new diterpenes from Pterodon pubescens","volume":"42","author":"Fascio","year":"1970","journal-title":"An Acad Brasil Ci\u00eanc"},{"issue":"Suplem.","key":"2024103012324119400_jphp12889-cit-0014","first-page":"103","article-title":"New diterpenoids from Pterodon emarginatus Vog","volume":"42","author":"Mahajan","year":"1970","journal-title":"An Acad Brasil Ci\u00eanc"},{"key":"2024103012324119400_jphp12889-cit-0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1039\/p19730000520","article-title":"New diterpenoids from Pterodon emarginatus","volume":"1","author":"Mahajan","year":"1973","journal-title":"J Chem Soc Perkin 1"},{"key":"2024103012324119400_jphp12889-cit-0016","first-page":"51","article-title":"New diterpenoids from Pterodon emarginatus Vog","volume":"44","author":"Mahajan","year":"1972","journal-title":"An Acad Bras Ci\u00eanc"},{"key":"2024103012324119400_jphp12889-cit-0017","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2005.01.014","article-title":"Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. Seeds","volume":"98","author":"Coelho","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0018","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10787-011-0081-9","article-title":"Anti-inflammatory and analgesic effects of 6\u03b1, 7\u03b2-dyhydroxy-vouacapan-17\u03b2-oic acid isolated from Pterodon emarginatus","volume":"19","author":"Galceran","year":"2011","journal-title":"Inflammapharmacology"},{"key":"2024103012324119400_jphp12889-cit-0019","first-page":"56","article-title":"Phytochemical and pharmacological analysis of Pterodon polygalaeflorus extracts","volume":"3","author":"Pinto","year":"2013","journal-title":"Pharmacol Online"},{"key":"2024103012324119400_jphp12889-cit-0020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/(SICI)1099-1573(199911)13:7<613::AID-PTR503>3.0.CO;2-D","article-title":"Successful treatment of collagen-induced arthritis in mice with hydroalcoholic extract of seeds of Pterodon pubescens","volume":"13","author":"Sabino","year":"1999","journal-title":"Phytother Res"},{"key":"2024103012324119400_jphp12889-cit-0021","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-4274(99)00110-1","article-title":"In vitro and in vivo toxicological studies of the Pterodon pubescens seed oil","volume":"108","author":"Sabino","year":"1999","journal-title":"Toxicol Lett"},{"key":"2024103012324119400_jphp12889-cit-0022","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0378-8741(01)00288-4","article-title":"Subacute toxicity evaluation of a hydroalcoholic extract of Pterodon pubescens seeds in mice with collagen-induced arthritis","volume":"77","author":"Coelho","year":"2001","journal-title":"J Ethnopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0023","first-page":"213","article-title":"Immunomodulatory effects of Sucupira (Pterodon pubescens) seed infusion on collagen-induced arthritis","volume":"22","author":"Coelho","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"2024103012324119400_jphp12889-cit-0024","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1211\/0022357022485","article-title":"Acute and topic antiedematogenic fractions isolated from the seeds of Pterodon pubescens","volume":"56","author":"Silva","year":"2004","journal-title":"J Pharm Pharmacol"},{"key":"2024103012324119400_jphp12889-cit-0025","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1055\/s-2007-967177","article-title":"Antiplatelet activity of geranylgeraniol isolated from Pterodon pubescens fruit oil is mediated by inhibition of cyclooxygenase-1","volume":"73","author":"Calixto","year":"2007","journal-title":"Planta Med"},{"key":"2024103012324119400_jphp12889-cit-0026","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/ol_00000094","article-title":"Pterodon pubescens seed extract induces the cell cycle arrest of leukemic cells by deregulating cyclin D1 and E2 mRNA levels","volume":"1","author":"Pereira","year":"2010","journal-title":"Oncol Lett"},{"key":"2024103012324119400_jphp12889-cit-0027","first-page":"215","article-title":"Terpenic subfraction of Pterodon pubescens induces apoptosis of K562 leukemic cells by modulating gene expression","volume":"1","author":"Pereira","year":"2011","journal-title":"Oncol Rep"},{"key":"2024103012324119400_jphp12889-cit-0028","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/1472-6882-12-231","article-title":"Terpenic fraction of Pterodon pubescens inhibits NF-kB and ERK 1\/2 activation and deregulates","volume":"12","author":"Pereira","year":"2012","journal-title":"BMC Complement Altern Med"},{"key":"2024103012324119400_jphp12889-cit-0029","first-page":"1547","article-title":"Antitumor screening of Pterodon pubescens terpenic fraction indicates high sensitivity for lymphocytic leukemia cells","volume":"9","author":"Martino","year":"2014","journal-title":"Nat Prod Commun"},{"key":"2024103012324119400_jphp12889-cit-0030","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0031-9422(00)89084-6","article-title":"Diterpenoids furans from Pterodon pubescens species","volume":"15","author":"Fascio","year":"1976","journal-title":"Phytochemistry"},{"key":"2024103012324119400_jphp12889-cit-0031","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Mass Spectroscopy","author":"Adams","year":"2007"},{"key":"2024103012324119400_jphp12889-cit-0032","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jep.2012.06.020","article-title":"Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain","volume":"143","author":"Nucci","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0033","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.talanta.2012.07.094","article-title":"Determination by GC\u2013MS-SIM of furano diterpenes in Pterodon pubescens Benth.: development and validation","volume":"100","author":"Hoscheid","year":"2012","journal-title":"Talanta"},{"key":"2024103012324119400_jphp12889-cit-0034","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/pca.2404","article-title":"Pterodon pubescens oil: characterization, certification of origin and quality control via mass spectrometry fingerprinting analysis","volume":"24","author":"Cabral","year":"2013","journal-title":"Phytochem Anal"},{"key":"2024103012324119400_jphp12889-cit-0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"key":"2024103012324119400_jphp12889-cit-0036","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival, application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"2024103012324119400_jphp12889-cit-0037","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc"},{"key":"2024103012324119400_jphp12889-cit-0038","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1182\/blood-2006-10-055319","article-title":"Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions","volume":"109","author":"Subramanian","year":"2007","journal-title":"Blood"},{"key":"2024103012324119400_jphp12889-cit-0039","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jlb.52.4.421","article-title":"Exudation of proliferative macrophages in local inflammation in the peritoneum","volume":"52","author":"Oghiso","year":"1992","journal-title":"J Leukoc Biol"},{"key":"2024103012324119400_jphp12889-cit-0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrgentox.2009.11.005","article-title":"TP53 mutation profile of esophageal squamous cell carcinomas of patients from Southeastern Brazil","volume":"696","author":"","year":"2010","journal-title":"Mutat Res"},{"key":"2024103012324119400_jphp12889-cit-0041","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"2024103012324119400_jphp12889-cit-0042","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.157.3791.950","article-title":"Chemoprophylactic agent in schistosomiasis: 14, 15-Epoxygeranylgeraniol","volume":"157","author":"Mors","year":"1967","journal-title":"Science"},{"key":"2024103012324119400_jphp12889-cit-0043","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/S0103-50532009000300024","article-title":"Furanditerpenes from Pterodon pubescens Benth with selective in vitro anticancer activity for prostate cell line","volume":"20","author":"Spindola","year":"2009","journal-title":"J Braz Chem Soc"},{"key":"2024103012324119400_jphp12889-cit-0044","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1590\/S0103-50531998000300014","article-title":"Isoflavonoids and triterpenoids isolated from Pterodon polygalaeflorus","volume":"9","author":"Marques","year":"1998","journal-title":"J Braz Chem Soc"},{"key":"2024103012324119400_jphp12889-cit-0045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bioorg.2009.03.004","article-title":"Effect of 6\u03b1,7\u03b2-dihydroxyvouacapan-17\u03b2-oic acid and its lactone derivatives on the growth of human cancer cells","volume":"37","author":"Euz\u00e9bio","year":"2009","journal-title":"Bioorg Chem"},{"key":"2024103012324119400_jphp12889-cit-0046","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"Guzik","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"2024103012324119400_jphp12889-cit-0047","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"key":"2024103012324119400_jphp12889-cit-0048","first-page":"e20987","article-title":"The role of nitric oxide in health and diseases","volume":"3","author":"Khazan","year":"2015","journal-title":"Scimetr"},{"key":"2024103012324119400_jphp12889-cit-0049","doi-asserted-by":"crossref","first-page":"5","DOI":"10.17305\/bjbms.2013.2402","article-title":"Nitric oxide as a potential biomarker in inflammatory bowel disease","volume":"13","author":"Avdagi\u0107","year":"2013","journal-title":"Bosn J Basic Med Sci"},{"key":"2024103012324119400_jphp12889-cit-0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3045","article-title":"Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus","volume":"12","author":"","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"2024103012324119400_jphp12889-cit-0051","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.canlet.2008.03.024","article-title":"Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer","volume":"268","author":"Hofseth","year":"2008","journal-title":"Cancer Lett"},{"key":"2024103012324119400_jphp12889-cit-0052","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13238-010-0018-x","article-title":"Nitric oxide: promoter or suppressor of programmed cell death?","volume":"1","author":"","year":"2010","journal-title":"Protein Cell"},{"key":"2024103012324119400_jphp12889-cit-0053","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10068-013-0030-z","article-title":"Antioxidant and anti-inflammatory activities of different solvent fractions from ethanol extract of Synurus deltoides (Aiton) nakai leaves","volume":"22","author":"","year":"2013","journal-title":"Food Sci Biotechnol"},{"key":"2024103012324119400_jphp12889-cit-0054","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev.pharmtox.41.1.203","article-title":"Novel effects of nitric oxide","volume":"41","author":"Davis","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2024103012324119400_jphp12889-cit-0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12013-011-9182-8","article-title":"LPS induced formation of immunoproteasomes: TNF-\u03b1 and nitric oxide production is regulated by altered composition of proteasome-active sites","volume":"60","author":"Reis","year":"2011","journal-title":"Cell Biochem Biophys"},{"key":"2024103012324119400_jphp12889-cit-0056","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jep.2010.12.020","article-title":"Euonymus alatus extract attenuates LPS-induced NF-\u03baB activation via IKK\u03b2 inhibition in RAW 264.7 cells","volume":"134","author":"Oh","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0057","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2009.01.028","article-title":"Suppressive effects of wild bitter gourd (Momordica charantia Linn. var. abbreviate ser.) fruit extracts on inflammatory responses in RAW264.7 macrophages","volume":"122","author":"Lii","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0058","doi-asserted-by":"crossref","first-page":"7216912","DOI":"10.1155\/2016\/7216912","article-title":"Anti-Inflammatory effect of Rhapontici Radix ethanol extract via inhibition of NF-\u03baB and MAPK and induction of HO-1 in macrophages","volume":"2016","author":"Jeong","year":"2016","journal-title":"Mediators Inflamm"},{"key":"2024103012324119400_jphp12889-cit-0059","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2567.2001.01261.x","article-title":"Nitric oxide and bone","volume":"103","author":"Van't Hof","year":"2001","journal-title":"Immunology"},{"key":"2024103012324119400_jphp12889-cit-0060","doi-asserted-by":"crossref","first-page":"FSO35","DOI":"10.4155\/fso.15.35","article-title":"Nitric oxide inhibition strategies","volume":"1","author":"Wong","year":"2015","journal-title":"Future Sci OA"},{"key":"2024103012324119400_jphp12889-cit-0061","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-\u03baB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2024103012324119400_jphp12889-cit-0062","doi-asserted-by":"crossref","first-page":"6599","DOI":"10.4049\/jimmunol.1002041","article-title":"Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages","volume":"185","author":"Iyer","year":"2010","journal-title":"J Immunol"},{"key":"2024103012324119400_jphp12889-cit-0063","first-page":"G39","article-title":"LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells","volume":"275","author":"Lichtman","year":"1998","journal-title":"Am J Physiol"},{"key":"2024103012324119400_jphp12889-cit-0064","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1742-2094-11-115","article-title":"Glimepiride reduces CD14 expression and cytokine secretion from macrophages","volume":"11","author":"","year":"2014","journal-title":"J Neuroinflammation"},{"key":"2024103012324119400_jphp12889-cit-0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.intimp.2011.01.012","article-title":"Triptolide and its expanding multiple pharmacological functions","volume":"11","author":"Liu","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0066","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/jlb.66.5.829","article-title":"Interleukin-1 production by mouse macrophages is regulated in a feedback fashion by nitric oxide","volume":"66","author":"","year":"1999","journal-title":"J Leukoc Biol"},{"key":"2024103012324119400_jphp12889-cit-0067","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its regulation","volume":"75","author":"Aktan","year":"2004","journal-title":"Life Sci"},{"key":"2024103012324119400_jphp12889-cit-0068","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2119\/molmed.2016.00017","article-title":"N, N-dimethylacetamide significantly attenuates LPS- and TNF\u03b1-induced proinflammatory responses via inhibition of the nuclear factor kappa B pathway","volume":"22","author":"Pekson","year":"2016","journal-title":"Mol Med"},{"key":"2024103012324119400_jphp12889-cit-0069","first-page":"887","article-title":"Cytokine-modulating strategies and newer cytokine targets for arthritis therapy","volume":"16","author":"","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2024103012324119400_jphp12889-cit-0070","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/aps.2012.100","article-title":"Lobolide, a diterpene, blockades the NF-\u03baB pathway and p38 and ERK MAPK activity in macrophages in vitro","volume":"33","author":"","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"2024103012324119400_jphp12889-cit-0071","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000237425","article-title":"Dexamethasone suppressed gene expression and production of Interleukin-10 by human peripheral blood mononuclear cells and monocytes","volume":"112","author":"Fushimi","year":"1997","journal-title":"Int Arch Allergy Immunol"},{"key":"2024103012324119400_jphp12889-cit-0072","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ni1275","article-title":"Immune cell migration in inflammation: present and future therapeutic targets","volume":"6","author":"","year":"2005","journal-title":"Nat Immunol"},{"key":"2024103012324119400_jphp12889-cit-0073","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.tips.2003.10.004","article-title":"Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease","volume":"24","author":"","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"2024103012324119400_jphp12889-cit-0074","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/ni.f.210","article-title":"Moving targets: cell migration inhibitors as new anti-inflammatory therapies","volume":"9","author":"MacKay","year":"2008","journal-title":"Nat Immunol"},{"key":"2024103012324119400_jphp12889-cit-0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/pharmaceutics3010107","article-title":"Cell migration and invasion assays as tools for drug discovery","volume":"3","author":"Hulkower","year":"2011","journal-title":"Pharmaceutics"},{"key":"2024103012324119400_jphp12889-cit-0076","first-page":"197","article-title":"The role of macrophages in the induction of antibody in X-irradiated animals","volume":"12","author":"Gallily","year":"1967","journal-title":"Immunology"},{"key":"2024103012324119400_jphp12889-cit-0077","doi-asserted-by":"crossref","first-page":"14.1.1","DOI":"10.1002\/0471142735.im1401s83","article-title":"The isolation and characterization of murine macrophages","volume":"83","author":"Zhang","year":"2008","journal-title":"Curr Protoc Immunol"},{"key":"2024103012324119400_jphp12889-cit-0078","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-62703-481-4_4","article-title":"Collecting resident or thioglycollate-elicited peritoneal macrophages","volume":"1031","author":"Schneider","year":"2013","journal-title":"Methods Mol Biol"},{"key":"2024103012324119400_jphp12889-cit-0079","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"2024103012324119400_jphp12889-cit-0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.intimp.2010.03.008","article-title":"Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes","volume":"10","author":"Marcuzzi","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"2024103012324119400_jphp12889-cit-0081","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00394-012-0429-y","article-title":"Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-\u03baB activation in rats","volume":"52","author":"Giriwono","year":"2013","journal-title":"Eur J Nutr"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/70\/6\/808\/60224657\/jphp12889.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/70\/6\/808\/60224657\/jphp12889.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:46:52Z","timestamp":1730310412000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/70\/6\/808\/6121732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":81,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12889","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,6]]},"published":{"date-parts":[[2018,6,1]]}}}