{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:05:56Z","timestamp":1740135956133,"version":"3.37.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordenadoria de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004611","name":"Secretaria da Ci\u00eancia, Tecnologia e Ensino Superior (SETI)\/Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004611","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Governo do Estado do Paran\u00e1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the analgesic effect of Glucantime (antimoniate N-methylglucamine) in Leishmania amazonensis infection and complete Freund's adjuvant (CFA), chronic paw inflammation model, in BALB\/c mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two models of chronic inflammatory pain in BALB\/c mice paw were used: infection with L. amazonensis and CFA stimulation. Both animals models received daily treatment with Glucantime (10 mg\/kg, i.p.) and during the treatment was measured the mechanical hyperalgesia with electronic version of von Frey filaments. After the treatment, the paw skin sample was collected for analysis of myeloperoxidase (MPO) and N-acetyl-\u03b2-glucosaminidase (NAG) activity, and IL-1\u03b2, TNF-\u03b1, IL-6, IFN-\u03b3 and IL-10 cytokines production by ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Leishmania amazonensis-induced chronic inflammation with significant increase in mechanical hyperalgesia, MPO and NAG activity, and IL-1\u03b2, TNF-\u03b1 and IL-6 production in the paw skin. Glucantime (10 mg\/kg, i.p.) inhibited L. amazonensis-induced mechanical hyperalgesia and IL-1\u03b2 and IL-6 cytokines productions. In chronic inflammatory model induced by CFA, Glucantime treatment during 7 days inhibited CFA-induced mechanical hyperalgesia, MPO and NAG activity, and IL-1\u03b2, TNF-\u03b1, IL-6 and IFN-\u03b3 production as well as increased IL-10 production.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data demonstrated that Glucantime reduced the chronic inflammatory pain induced by L. amazonensis and CFA stimuli by inhibiting the hyperalgesic cytokines production.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12896","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:13:50Z","timestamp":1521108830000},"page":"768-777","source":"Crossref","is-referenced-by-count":8,"title":["Glucantime reduces mechanical hyperalgesia in cutaneous leishmaniasis and complete Freund's adjuvant models of chronic inflammatory pain"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6251-0386","authenticated-orcid":false,"given":"Suelen S","family":"da Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Experimental, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra S","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de dor e Inflama\u00e7\u00e3o, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline R","family":"Fanti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Experimental, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idessania N","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Experimental, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular, Instituto Carlos Chagas (ICC\/Fiocruz\/PR) , Curitiba,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ionice","family":"Felipe","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Experimental, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wander R","family":"Pavanelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Experimental, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-9283","authenticated-orcid":false,"given":"Waldiceu A","family":"Verri","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de dor e Inflama\u00e7\u00e3o, Departamento de Ci\u00eancias Patol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Londrina (UEL) , Londrina, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivete","family":"Conchon 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