{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:18:43Z","timestamp":1777393123628,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["p07\/547"],"award-info":[{"award-number":["p07\/547"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Inflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to explore the anti-inflammatory role of PTY-2r (extracted from Pueraria tuberosa), on streptozotocin (STZ)-induced DN rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Diabetes was induced by intraperitoneal injection of STZ (55mg\/kg) in rats. After 60 days, the rats were randomly divided into three groups (n = 6\/each group), namely DN control group 2, DN rats treated with PTY-2r at dose of 100 mg\/100 g, group 3 and 50 mg\/100 g, group 4, p.o for 20 days. The normal rats were chosen as a normal control (NC) group 1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>In DN rats, the expression of iNOS and inflammatory cytokines (IL-6 and TNF-\u03b1) was significantly increased. Raised expression of PKC-\u03b1 was also found. As NF-kB is the main transcription factor for the inflammatory response-mediated progression of DN, variation in NF-kB expression and its activated phosphorylated derivative (pNF-kB) were also evaluated and increase in expression was obtained in the kidney of DN rats. PTY-2r treatment significantly reversed these changes in dose-dependent manner.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study suggested that the nephroprotective effect of PTY-2r is possibly due to downregulation of PKC-\u03b1 and NF-kB pathway and normalizing the expression of inflammatory cytokines and iNOS in the kidney of DN rats.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12931","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T03:04:25Z","timestamp":1526526265000},"page":"1102-1112","source":"Crossref","is-referenced-by-count":28,"title":["<i>Pueraria tuberosa<\/i> extract inhibits iNOS and IL-6 through suppression of PKC-\u03b1 and NF-kB pathway in diabetes-induced nephropathy"],"prefix":"10.1093","volume":"70","author":[{"given":"Rashmi","family":"Shukla","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University , Varanasi,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somanshu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Zoology, Institute of Science, Banaras Hindu University , Varanasi,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-1109","authenticated-orcid":false,"given":"Yamini B","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University , Varanasi,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"2024103012314365900_jphp12931-cit-0001","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: 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