{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:18:23Z","timestamp":1761718703320,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In the present study, we have elaborated the anti-inflammatory mechanism of MSM through homing of CD34+ stem cells towards an inflamed region by regulating hydrogen sulfide (H2S) in an in vivo model of caerulein-induced acute pancreatitis (AP) and associated lung injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Male Swiss mice were treated with hourly intraperitoneal injections of caerulein (50 \u03bcg\/kg) for 6 h. MSM (500 mg\/kg) was administered intraperitoneally 1 h after the first caerulein injection (therapeutic). The serum amylase activity and myeloperoxidase (MPO) activity in lung and pancreas were measured. The levels of H2S and interleukin (IL)-1\u03b2, cystathionine-\u03b3-lyase (CSE) and CD34+ expressions in pancreas and lungs were determined by RT-PCR and ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key Findings<\/jats:title>\n                  <jats:p>Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes, decreased serum amylase, MPO activity and inhibited caerulein-induced IL-1\u03b2 expression. Furthermore, MSM reduced caerulein-induced H2S levels by alleviating the expression of CSE in pancreas and lungs and increased CD34 expression and inhibited nuclear factor (NF)-\u03baB translocation in caerulein-induced AP and associated lung injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings indicate that MSM can effectively reduce inflammatory responses and induce the homing of CD34+ cells to the injured tissues.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12946","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T02:19:37Z","timestamp":1530670777000},"page":"1188-1199","source":"Crossref","is-referenced-by-count":15,"title":["Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice"],"prefix":"10.1093","volume":"70","author":[{"given":"Ranjith Kumar","family":"Velusamy","sequence":"first","affiliation":[{"name":"School of Biosciences and Technology, VIT University , Vellore, Tamil Nadu,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-6308","authenticated-orcid":false,"given":"Ramasamy","family":"Tamizhselvi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Technology, VIT University , Vellore, Tamil Nadu,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2024103012294360400_jphp12946-cit-0001","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<117::AID-PATH494>3.0.CO;2-K","article-title":"Inflammatory mediators in acute pancreatitis","volume":"190","author":"Bhatia","year":"2000","journal-title":"J 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