{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:46:51Z","timestamp":1790185611733,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Medical research and development","award":["971399"],"award-info":[{"award-number":["971399"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cisplatin is one of the widely used antitumour agents with major clinical side effect, nephrotoxicity. We showed the role of iron in cisplatin-induced nephrotoxicity that entrance to the cell via transferrin receptor (TfR) as a gatekeeper for iron uptake. We also examined the effect of iron chelator deferiprone against this toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty male Wistar rats were randomly divided into six groups. Group I (saline orally for 10 days); group II (saline orally for 10 days plus single injection of cisplatin 7 mg\/kg, intraperitoneally on 5th day); groups III, IV and V (deferiprone 50, 100 and 200 mg\/kg orally for 10 days, respectively, plus cisplatin on 5th day). Group VI (deferiprone, orally).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Deferiprone provided functional and significant histological-proven protection in group IV. Deferiprone attenuated the increased creatinine, BUN, malondialdehyde and iron concentrations in cisplatin-injected animals. The increased amounts of TfR and decreased levels of HIF-1\u03b1 and related anti-apoptotic genes expression in cisplatin-treated animals were improved by deferiprone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results supported a role for iron in cisplatin-induced nephrotoxicity and TfR may serve as an important source of iron. Based on these findings, deferiprone pretreatment may play a role in preventing cisplatin-induced nephropathy in cancer patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.12990","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T20:59:08Z","timestamp":1532638748000},"page":"1357-1368","source":"Crossref","is-referenced-by-count":26,"title":["Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats"],"prefix":"10.1093","volume":"70","author":[{"given":"Pouran","family":"Makhdoumi","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Pharmacodynamics and Toxicology, School of Pharmacy , Mashhad,","place":["Iran"]},{"name":"Pharmaceutical Research Center , Mashhad,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Abnous","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soghra","family":"Mehri","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, Pharmacy School, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Etemad","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-0421","authenticated-orcid":false,"given":"Mohsen","family":"Imenshahidi","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, Pharmacy School, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-5448","authenticated-orcid":false,"given":"Gholamreza","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, Pharmacy School, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , 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