{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:11:35Z","timestamp":1791645095287,"version":"4.3.4"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Multiusu\u00e1ria de Laborat\u00f3rios de Pesquisa da UEL"},{"name":"Centro Especializado em Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade da UEL"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the effects of a topical emulsion containing pyrrolidine dithiocarbamate (PDTC) (EcPDTC) in skin oxidative stress and inflammation triggered by ultraviolet B (UVB) irradiation (dose of 4.14 J\/cm2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Hairless mouse received treatment with 0.5 g of EcPDTC or control emulsion (CTRLE) on the dorsal surface skin 12 h, 6 h and 5 min before and 6 h after the irradiation. Oxidative stress was evaluated by ferric reducing antioxidant power (FRAP), 2,2\u2032-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS) scavenging capacity, reduced glutathione quantitation, catalase activity, superoxide anion production and lipid peroxidation products. Inflammation parameters were as follows: skin oedema, myeloperoxidase activity (neutrophil marker), matrix metalloproteinase-9 activity, collagen fibre damage, mast cell and sunburn cell counts, and cytokine production.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Topical treatment with EcPDTC protected from UVB-induced skin injury by maintaining the antioxidant capacity levels similar to non-irradiated control group. Furthermore, EcPDTC inhibited UVB irradiation-induced superoxide anion production, lipid peroxidation and reduced skin inflammation by inhibiting skin oedema, neutrophil recruitment, metalloproteinase-9 activity, collagen fibre damage, mast cell and sunburn cell counts, and cytokine (TNF-\u03b1 and IL-1\u03b2) production.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Topical treatment with EcPDTC improves antioxidant systems and inhibits inflammation, protecting the skin from the damaging effects of UVB irradiation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12997","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:32:31Z","timestamp":1534955551000},"page":"1461-1473","source":"Crossref","is-referenced-by-count":5,"title":["Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin"],"prefix":"10.1093","volume":"70","author":[{"given":"Renata M","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L M","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Vale","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Z","family":"Campanini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor S","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius S","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana T M C","family":"Vicentini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of Sao Paulo , Ribeir\u00e3o Preto,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda M P","family":"Vilela","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of Sao Paulo , Ribeir\u00e3o Preto,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J V","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of Sao Paulo , Ribeir\u00e3o Preto,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela M","family":"Baracat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra R","family":"Georgetti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-9283","authenticated-orcid":false,"given":"Waldiceu A","family":"Verri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-1668","authenticated-orcid":false,"given":"R\u00fabia","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Health Science Center, State University of Londrina , Londrina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"2024103012315624000_jphp12997-cit-0001","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1751-1097.1996.tb03040.x","article-title":"Photocarcinogenesis: mechanisms, models and human health implications","volume":"63","author":"Mukhtar","year":"1996","journal-title":"Photochem Photobiol"},{"key":"2024103012315624000_jphp12997-cit-0002","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2010.12.007","article-title":"Natural agents: cellular and molecular mechanisms of photoprotection","volume":"508","author":"Afaq","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"2024103012315624000_jphp12997-cit-0003","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrfmmm.2004.09.013","article-title":"Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis","volume":"571","author":"Halliday","year":"2005","journal-title":"Mutat Res"},{"key":"2024103012315624000_jphp12997-cit-0004","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1011-1344(01)00207-X","article-title":"Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms","volume":"63","author":"Girotti","year":"2001","journal-title":"J Photochem Photobiol, B"},{"key":"2024103012315624000_jphp12997-cit-0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1189\/jlb.0408230","article-title":"Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC","volume":"87","author":"Kilpatrick","year":"2010","journal-title":"J Leukoc Biol"},{"key":"2024103012315624000_jphp12997-cit-0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0006-2952(99)00296-8","article-title":"Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries","volume":"59","author":"Bowie","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"2024103012315624000_jphp12997-cit-0007","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2015.08.015","article-title":"Superoxide anion-induced pain and inflammation depends on TNF\u03b1\/TNFR1 signaling in mice","volume":"605","author":"Yamacita-Borin","year":"2015","journal-title":"Neurosci Lett"},{"key":"2024103012315624000_jphp12997-cit-0008","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2017.01.029","article-title":"Sunlight damage to cellular DNA: focus on oxidatively generated lesions","volume":"107","author":"Schuch","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"2024103012315624000_jphp12997-cit-0009","first-page":"3","article-title":"Lipid peroxidation: chemical mechanism, biological implications and analytical determination","volume":"3","author":"Repetto","year":"2012","journal-title":"World's Larg Sci Technol Med Open Access B Publ"},{"key":"2024103012315624000_jphp12997-cit-0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1034\/j.1600-0625.2001.010003155.x","article-title":"The molecular determinants of sunburn cell formation","volume":"10","author":"Murphy","year":"2001","journal-title":"Exp Dermatol"},{"key":"2024103012315624000_jphp12997-cit-0011","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jphotobiol.2017.05.002","article-title":"Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice","volume":"171","author":"Martinez","year":"2017","journal-title":"J Photochem Photobiol B Biol"},{"key":"2024103012315624000_jphp12997-cit-0012","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jphotobiol.2013.08.007","article-title":"Efficacy of topical formulations containing Pimenta pseudocaryophyllus extract against UVB-induced oxidative stress and inflammation in hairless mice","volume":"127","author":"Campanini","year":"2013","journal-title":"J Photochem Photobiol, B"},{"key":"2024103012315624000_jphp12997-cit-0013","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1208\/s12249-013-0049-8","article-title":"Topical formulations containing Pimenta pseudocaryophyllus extract: in vitro antioxidant activity and in vivo efficacy against UV-B-induced oxidative stress","volume":"15","author":"Campanini","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"2024103012315624000_jphp12997-cit-0014","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/acs.jnatprod.5b00198","article-title":"Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice","volume":"78","author":"Martinez","year":"2015","journal-title":"J Nat Prod"},{"key":"2024103012315624000_jphp12997-cit-0015","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1021\/acs.jnatprod.5b01132","article-title":"Resveratrol-loaded liquid-crystalline system inhibits UVB-induced skin inflammation and oxidative stress in mice","volume":"79","author":"Fujimura","year":"2016","journal-title":"J Nat Prod"},{"key":"2024103012315624000_jphp12997-cit-0016","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jnutbio.2011.01.009","article-title":"Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms","volume":"23","author":"Staniforth","year":"2012","journal-title":"J Nutr Biochem"},{"key":"2024103012315624000_jphp12997-cit-0017","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jphotobiol.2015.03.030","article-title":"Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage","volume":"148","author":"Martinez","year":"2015","journal-title":"J Photochem Photobiol, B"},{"key":"2024103012315624000_jphp12997-cit-0018","doi-asserted-by":"crossref","first-page":"17705","DOI":"10.3390\/ijms151017705","article-title":"Local melatoninergic system as the protector of skin integrity","volume":"15","author":"Slominski","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2024103012315624000_jphp12997-cit-0019","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jphotobiol.2006.01.006","article-title":"Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice","volume":"84","author":"Casagrande","year":"2006","journal-title":"J Photochem Photobiol, B"},{"key":"2024103012315624000_jphp12997-cit-0020","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1039\/c5pp00467e","article-title":"Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation","volume":"15","author":"Martinez","year":"2016","journal-title":"Photochem Photobiol Sci"},{"key":"2024103012315624000_jphp12997-cit-0021","doi-asserted-by":"crossref","first-page":"e0146296","DOI":"10.1371\/journal.pone.0146296","article-title":"Topical formulation containing naringenin: efficacy against ultraviolet B irradiation-induced skin inflammation and oxidative stress in mice","volume":"11","author":"Martinez","year":"2016","journal-title":"PLoS ONE"},{"key":"2024103012315624000_jphp12997-cit-0022","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jsps.2009.10.001","article-title":"An insight into the possible protective effect of pyrrolidine dithiocarbamate against lipopolysaccharide-induced oxidative stress and acute hepatic injury in rats","volume":"17","author":"Hagar","year":"2009","journal-title":"Saudi Pharm J"},{"key":"2024103012315624000_jphp12997-cit-0023","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2164\/jandrol.108.006270","article-title":"Chemoprotective effect of a nuclear factor-kappaB inhibitor, pyrrolidine dithiocarbamate, against cisplatin-induced testicular damage in rats","volume":"30","author":"Ilbey","year":"2009","journal-title":"J Androl"},{"key":"2024103012315624000_jphp12997-cit-0024","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s00268-007-9106-3","article-title":"Pyrrolidine dithiocarbamate prevents deleterious effects of remote ischemia\/reperfusion injury on healing of colonic anastomoses in rats","volume":"31","author":"Teke","year":"2007","journal-title":"World J Surg"},{"key":"2024103012315624000_jphp12997-cit-0025","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1007\/s00268-007-9112-5","article-title":"Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia\/reperfusion in a rat model","volume":"31","author":"Kabay","year":"2007","journal-title":"World J Surg"},{"key":"2024103012315624000_jphp12997-cit-0026","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00268-006-0013-9","article-title":"Effects of pyrrolidine dithiocarbamate on healing of colonic anastomoses in the cecal ligation and puncture model of intraperitoneal sepsis in rats","volume":"31","author":"Teke","year":"2007","journal-title":"World J Surg"},{"key":"2024103012315624000_jphp12997-cit-0027","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jphotobiol.2014.05.010","article-title":"Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro","volume":"138","author":"Ivan","year":"2014","journal-title":"J Photochem Photobiol B Biol"},{"key":"2024103012315624000_jphp12997-cit-0028","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.amjsurg.2006.06.054","article-title":"Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischemia\/reperfusion injury in rats","volume":"194","author":"Teke","year":"2007","journal-title":"Am J Surg"},{"key":"2024103012315624000_jphp12997-cit-0029","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1007\/s11033-013-2676-2","article-title":"Protective effects of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate in bladder ischemia-reperfusion injury in rats","volume":"40","author":"Yucel","year":"2013","journal-title":"Mol Biol Rep"},{"key":"2024103012315624000_jphp12997-cit-0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000119699","article-title":"Effects of pyrrolidine dithiocarbamate on antioxidant enzymes in cardiomyopathy induced by adriamycin in rats","volume":"111","author":"Mingyan","year":"2008","journal-title":"Cardiology"},{"key":"2024103012315624000_jphp12997-cit-0031","first-page":"209","article-title":"Antioxidant properties of pyrrolidine dithiocarbamate and its protection against Cr(VI)-induced DNA strand breakage","volume":"30","author":"Shi","year":"2000","journal-title":"Ann Clin Lab Sci"},{"key":"2024103012315624000_jphp12997-cit-0032","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.lfs.2009.06.019","article-title":"Effects of pyrrolidine dithiocarbamate on high-fat diet-induced metabolic and renal alterations in rats","volume":"85","author":"Ebenezer","year":"2009","journal-title":"Life Sci"},{"key":"2024103012315624000_jphp12997-cit-0033","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejphar.2008.07.064","article-title":"Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion","volume":"595","author":"Lee","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"2024103012315624000_jphp12997-cit-0034","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0168-8278(01)00290-2","article-title":"Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats","volume":"36","author":"Bruck","year":"2002","journal-title":"J Hepatol"},{"key":"2024103012315624000_jphp12997-cit-0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3171\/spi.2004.1.3.0311","article-title":"Inhibition of the nuclear factor-kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats","volume":"1","author":"La Rosa","year":"2004","journal-title":"J Neurosurg Spine"},{"key":"2024103012315624000_jphp12997-cit-0036","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/01.shk.0000093543.78705.aa","article-title":"Pyrrolidine dithiocarbamate reduces the severity of cerulein-induced murine acute pancreatitis","volume":"20","author":"Virlos","year":"2003","journal-title":"Shock"},{"key":"2024103012315624000_jphp12997-cit-0037","first-page":"165","article-title":"Protective effect of pyrrolidine dithiocarbamate on erythrocytes during canine cardiopulmonary bypass","volume":"30","author":"Fang","year":"2008","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"2024103012315624000_jphp12997-cit-0038","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1007\/s00134-003-1887-8","article-title":"Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice","volume":"29","author":"Cuzzocrea","year":"2003","journal-title":"Intensive Care Med"},{"key":"2024103012315624000_jphp12997-cit-0039","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3748\/wjg.v12.i3.388","article-title":"Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia\/reperfusion in rats","volume":"12","author":"Tian","year":"2006","journal-title":"World J Gastroenterol"},{"key":"2024103012315624000_jphp12997-cit-0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2012.10.018","article-title":"Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats","volume":"238","author":"Zhao","year":"2013","journal-title":"Behav Brain Res"},{"key":"2024103012315624000_jphp12997-cit-0041","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3109\/02713683.2011.606591","article-title":"Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats","volume":"36","author":"Sun","year":"2011","journal-title":"Curr Eye Res"},{"key":"2024103012315624000_jphp12997-cit-0042","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1476-5381.2011.01360.x","article-title":"Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension","volume":"164","author":"Cau","year":"2011","journal-title":"Br J Pharmacol"},{"key":"2024103012315624000_jphp12997-cit-0043","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3748\/wjg.v13.i11.1666","article-title":"Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis","volume":"13","author":"Hirata","year":"2007","journal-title":"World J Gastroenterol"},{"key":"2024103012315624000_jphp12997-cit-0044","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10787-016-0266-3","article-title":"Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-??B and oxidative stress","volume":"24","author":"Pinho-Ribeiro","year":"2016","journal-title":"Inflammopharmacology"},{"key":"2024103012315624000_jphp12997-cit-0045","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1742-7843.2010.00573.x","article-title":"Pre-clinical safety evaluation of pyrrolidine dithiocarbamate","volume":"107","author":"Chabicovsky","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2024103012315624000_jphp12997-cit-0046","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1084\/jem.175.5.1181","article-title":"Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells","volume":"175","author":"Schreck","year":"1992","journal-title":"J Exp Med"},{"key":"2024103012315624000_jphp12997-cit-0047","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1007\/s12010-015-1848-z","article-title":"Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis","volume":"177","author":"Yin","year":"2015","journal-title":"Appl Biochem Biotechnol"},{"key":"2024103012315624000_jphp12997-cit-0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.12.034","article-title":"Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor \u03baB","volume":"261","author":"Zhang","year":"2014","journal-title":"Neuroscience"},{"key":"2024103012315624000_jphp12997-cit-0049","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.3892\/mmr.2016.5655","article-title":"Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line","volume":"14","author":"Song","year":"2016","journal-title":"Mol Med Rep"},{"key":"2024103012315624000_jphp12997-cit-0050","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/nmat4422","article-title":"A sunblock based on bioadhesive nanoparticles","volume":"14","author":"Deng","year":"2015","journal-title":"Nat Mater"},{"key":"2024103012315624000_jphp12997-cit-0051","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/1523-1747.ep12606202","article-title":"Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells","volume":"104","author":"Schwarz","year":"1995","journal-title":"J Invest Dermatol"},{"key":"2024103012315624000_jphp12997-cit-0052","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1039\/c6pp00442c","article-title":"trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production","volume":"16","author":"Martinez","year":"2017","journal-title":"Photochem Photobiol Sci"},{"key":"2024103012315624000_jphp12997-cit-0053","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cca.2005.01.005","article-title":"Gender differences in antioxidant capacity of rat tissues determined by 2,2\u2019-azinobis (3-ethylbenzothiazoline 6-sulfonate; ABTS) and ferric reducing antioxidant power (FRAP) assays","volume":"140","author":"Katalinic","year":"2005","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"2024103012315624000_jphp12997-cit-0054","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0014-827X(00)00037-9","article-title":"Fluorescent probes as markers of oxidative stress in keratinocyte cell lines following UVB exposure","volume":"55","author":"Carini","year":"2000","journal-title":"Farmaco"},{"key":"2024103012315624000_jphp12997-cit-0055","first-page":"158","article-title":"Pharmacology of free radicals and the impact of reactive oxygen species on the testis","volume":"14","author":"Aprioku","year":"2013","journal-title":"J Reprod Infertil"},{"key":"2024103012315624000_jphp12997-cit-0056","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.3390\/molecules19056202","article-title":"Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation","volume":"19","author":"Amaro-Ortiz","year":"2014","journal-title":"Molecules"},{"key":"2024103012315624000_jphp12997-cit-0057","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/exd.12032","article-title":"Intercellular pathway through hyaluronic acid in UVB-induced inflammation","volume":"21","author":"Hiramoto","year":"2012","journal-title":"Exp Dermatol"},{"key":"2024103012315624000_jphp12997-cit-0058","first-page":"30201","article-title":"Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice","volume":"18","author":"Martinez","year":"2018","journal-title":"J Dermatol Sci"},{"key":"2024103012315624000_jphp12997-cit-0059","first-page":"1200","article-title":"Polyphenols: skin photoprotection and inhibition of photocarcinogenesis","volume":"11","author":"Afaq","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"2024103012315624000_jphp12997-cit-0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00024382-199807000-00009","article-title":"Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin","volume":"10","author":"N\u00e9meth","year":"1998","journal-title":"Shock"},{"key":"2024103012315624000_jphp12997-cit-0061","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.4049\/jimmunol.159.8.3976","article-title":"In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock","volume":"159","author":"Liu","year":"1997","journal-title":"J Immunol"},{"key":"2024103012315624000_jphp12997-cit-0062","first-page":"619487","article-title":"Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats","volume":"2009","author":"Chang","year":"2009","journal-title":"J Biomed Biotechnol"},{"key":"2024103012315624000_jphp12997-cit-0063","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.bjp.0704463","article-title":"Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation","volume":"135","author":"Cuzzocrea","year":"2002","journal-title":"Br J Pharmacol"},{"key":"2024103012315624000_jphp12997-cit-0064","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-016-0515-9","article-title":"Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes","volume":"13","author":"Liddell","year":"2016","journal-title":"J Neuroinflammation"},{"key":"2024103012315624000_jphp12997-cit-0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0014-5793(02)03637-2","article-title":"Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage","volume":"532","author":"Zhu","year":"2002","journal-title":"FEBS Lett"},{"key":"2024103012315624000_jphp12997-cit-0066","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1073\/pnas.0712116105","article-title":"IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice","volume":"105","author":"Verri","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024103012315624000_jphp12997-cit-0067","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-9877(88)90084-9","article-title":"Optimal dithiocarbamate structure for immunomodulator action","volume":"27","author":"Topping","year":"1988","journal-title":"Med Hypotheses"},{"key":"2024103012315624000_jphp12997-cit-0068","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0891-5849(98)00300-1","article-title":"Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress","volume":"26","author":"Moellering","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"2024103012315624000_jphp12997-cit-0069","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/41.12.1819","article-title":"Lipid peroxidation and antioxidants as biomarkers of tissue damage","volume":"41","author":"Gutteridge","year":"1995","journal-title":"Clin Chem"},{"key":"2024103012315624000_jphp12997-cit-0070","first-page":"385","article-title":"Chemopreventive effects of Calluna vulgaris and Vitis vinifera extracts on UVB-induced skin damage in SKH-1 hairless mice","volume":"62","author":"Filip","year":"2011","journal-title":"J Physiol Pharmacol"},{"key":"2024103012315624000_jphp12997-cit-0071","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/clpt.2010.221","article-title":"Photoaged skin: the role of neutrophils, preventive measures, and potential pharmacological targets","volume":"89","author":"Rijken","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"2024103012315624000_jphp12997-cit-0072","first-page":"491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Duque","year":"2014","journal-title":"Front Immunol"},{"key":"2024103012315624000_jphp12997-cit-0073","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2133.2009.09467.x","article-title":"A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis","volume":"162","author":"Harper","year":"2010","journal-title":"Br J Dermatol"},{"key":"2024103012315624000_jphp12997-cit-0074","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jphotobiol.2017.06.042","article-title":"Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin","volume":"173","author":"Che","year":"2017","journal-title":"J Photochem Photobiol B Biol"},{"key":"2024103012315624000_jphp12997-cit-0075","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1023\/A:1015322514547","article-title":"Pathways involved in mild gastrointestinal inflammation induced by a low level exposure to a food contaminant","volume":"47","author":"Anton","year":"2002","journal-title":"Dig Dis Sci"},{"key":"2024103012315624000_jphp12997-cit-0076","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1099\/jgv.0.000625","article-title":"The NS1 protein of avian influenza virus H9N2 induces oxidative-stress-mediated chicken oviduct epithelial cells apoptosis","volume":"97","author":"Qi","year":"2016","journal-title":"J Gen Virol"},{"key":"2024103012315624000_jphp12997-cit-0077","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/B978-0-444-53836-9.00026-8","article-title":"Flavonoids as anti-inflammatory and analgesic drugs: mechanisms of action and perspectives in the development of pharmaceutical forms","volume":"36","author":"Verri","year":"2012","journal-title":"Stud Nat Prod Chem"},{"key":"2024103012315624000_jphp12997-cit-0078","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1468-3083.2003.00751.x","article-title":"Antioxidant activity, lipid peroxidation and skin diseases. What's new","volume":"17","author":"Briganti","year":"2003","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024103012315624000_jphp12997-cit-0079","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jdermsci.2011.01.002","article-title":"Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-kappaB pathway","volume":"61","author":"Vicentini","year":"2011","journal-title":"J Dermatol Sci"},{"key":"2024103012315624000_jphp12997-cit-0080","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/10552","article-title":"Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis","volume":"5","author":"Moore","year":"1999","journal-title":"Nat Med"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/70\/11\/1461\/60224068\/jphp12997.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/70\/11\/1461\/60224068\/jphp12997.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:43:07Z","timestamp":1730310187000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/70\/11\/1461\/6121707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":80,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,1]]},"published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12997","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11]]},"published":{"date-parts":[[2018,11,1]]}}}