{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:07:46Z","timestamp":1778670466742,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brazilian Health Surveillance Agency","award":["TC 07\/2012"],"award-info":[{"award-number":["TC 07\/2012"]}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","award":["Aux\u00edlio Pesquisador\/PROPP\/UFOP"],"award-info":[{"award-number":["Aux\u00edlio Pesquisador\/PROPP\/UFOP"]}],"id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To perform the polymorphic and physicochemical characterization of the potential anti-inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct solvents: chloroform (EREC 1) and ethyl acetate (EREC 2). To evaluate the polymorphism, EREC samples were submitted to melting point, purity, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray powder diffraction, optical microscopy and scanning electron microscopy analysis. In addition, EREC samples crystallized after intrinsic dissolution study were submitted to DSC and X-ray powder diffraction analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>EREC 1 showed fusion at 234.7\u2013241.6 \u00b0C, while EREC 2 showed fusion at 238.6\u2013243.7 \u00b0C. No polymorphic transitions were observed during the intrinsic dissolution experiment. A single sharp endothermic peak was obtained for the EREC samples. X-ray diffraction showed no crystallographic differences between the EREC samples. EREC 1 and EREC 2 showed birefringence under polarized light and indefinite morphology; however, the shape of the crystals was common to the two samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Eremantholide C does not present classical or morphological polymorphism; therefore, there is no influence of crystalline transitions in the solubility and consequently in its biopharmaceutics classification and oral absorption process.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13080","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T02:55:12Z","timestamp":1550458512000},"page":"910-919","source":"Crossref","is-referenced-by-count":3,"title":["Polymorphic characterization and implications on biopharmaceutics properties of potential anti-inflammatory drug candidate eremantholide C from <i>Lychnophora trichocarpha<\/i> (Brazilian Arnica)"],"prefix":"10.1093","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-0134","authenticated-orcid":false,"given":"Tamires G","family":"Caldeira","sequence":"first","affiliation":[{"name":"Escola de Farm\u00e1cia, Universidade Federal de Ouro Preto , Ouro Preto, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00eania A","family":"Sa\u00fade-Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Escola de Farm\u00e1cia, Universidade Federal de Ouro Preto , Ouro Preto, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e2maris L R","family":"De Lacerda","sequence":"additional","affiliation":[{"name":"Escola de Farm\u00e1cia, Universidade Federal de Ouro Preto , Ouro Preto, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner Da Nova","family":"Mussel","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Irene","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-023X","authenticated-orcid":false,"given":"Jacqueline","family":"De Souza","sequence":"additional","affiliation":[{"name":"Escola de Farm\u00e1cia, Universidade Federal de Ouro Preto , Ouro Preto, Minas Gerais,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"2024103012344494000_jphp13080-cit-0001","first-page":"551","article-title":"A\u00e7\u00e3o analg\u00e9sica do extrato bruto aquoso liofilizado do caule e folhas de Lychnophora ericoides Mart","volume":"39","author":"Cerqueira","year":"1987","journal-title":"Cien Cult"},{"key":"2024103012344494000_jphp13080-cit-0002","first-page":"90","article-title":"Constituents from the aerial parts of Lychnophora trichocarpha","volume":"69","author":"Sa\u00fade","year":"1998","journal-title":"Fitoterapia"},{"key":"2024103012344494000_jphp13080-cit-0003","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jep.2012.06.012","article-title":"Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: Anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents","volume":"142","author":"de Souza","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"2024103012344494000_jphp13080-cit-0004","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bjp.2015.06.003","article-title":"Useful brazilian plants under the view of the writer-naturalist Jo\u00e3o Guimar\u00e3es Rosa","volume":"25","author":"Chaves","year":"2015","journal-title":"Rev Bras Farmacogn"},{"key":"2024103012344494000_jphp13080-cit-0005","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ptr.4736","article-title":"Anti-inflammatory sesquiterpene lactones from Lychnophora trichocarpha Spreng. 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