{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:11:35Z","timestamp":1776114695480,"version":"3.50.1"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373371"],"award-info":[{"award-number":["81373371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M560410"],"award-info":[{"award-number":["2014M560410"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M560409"],"award-info":[{"award-number":["2014M560409"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Cuminaldehyde self-emulsified nanoemulsion (CuA-SEN) was prepared and optimised to improve its oral bioavailability and antihepatotoxicity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cuminaldehyde self-emulsified nanoemulsion was developed through the self-nanoemulsification method using Box\u2013Behnken Design (BBD) tool while appropriate physicochemical indices were evaluated. The optimised CuA-SEN was characterised via droplet size (DS), morphology, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency, in-vitro release, and pharmacokinetic studies while its antihepatotoxicity was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Cuminaldehyde self-emulsified nanoemulsion with acceptable characteristics (mean DS-48.83 \u00b1 1.06 nm; PDI-0.232 \u00b1 0.140; ZP-29.92 \u00b1 1.66 mV; EE-91.51 \u00b1 0.44%; and drug-loading capacity (DL)-9.77 \u00b1 0.75%) was formulated. In-vitro drug release of CuA-SEN significantly increased with an oral relative bioavailability of 171.02%. Oral administration of CuA-SEN to CCl4-induced hepatotoxicity mice markedly increased the levels of superoxide dismutase, glutathione and catalase in serum. Also, CuA-SEN reduced the levels of tumour necrosis factor-alpha and interleukin-6 in both serum and liver tissues while aspartate aminotransferase, alanine aminotransferase and malonaldehyde levels were significantly decreased.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings showed that the improved bioavailability of cuminaldehyde via SEN provided an effective approach for enhancing antioxidation, anti-inflammation and antihepatotoxicity of the drug.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13112","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T05:24:58Z","timestamp":1559798698000},"page":"1324-1338","source":"Crossref","is-referenced-by-count":21,"title":["Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice"],"prefix":"10.1093","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-4261","authenticated-orcid":false,"given":"Michael","family":"Adu-Frimpong","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]},{"name":"Department of Basic and Biomedical Sciences, College of Health and Well-Being , Kintampo, Bono Region,","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qiuyu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb Kesse","family":"Firempong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology , Kumasi,","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusif Mohammed","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Omari-Siaw","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Kumasi Technical University , Kumasi,","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Lijun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangnan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Tissue Engineering, School of Pharmacy, Jiangsu University , Zhenjiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"key":"2024103012335330800_jphp13112-cit-0001","first-page":"1669","article-title":"Extraction optimization and in vitro antioxidant properties of phenolic compounds from cumin (Cuminum cyminum L.) seed","volume":"20","author":"Al Juhaimi","year":"2013","journal-title":"Int Food Res 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