{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:24:31Z","timestamp":1770139471881,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30371632"],"award-info":[{"award-number":["30371632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and technology Foundation of Chongqing Education Commission","award":["KJ1600201"],"award-info":[{"award-number":["KJ1600201"]}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2017jcyjAX0228"],"award-info":[{"award-number":["cstc2017jcyjAX0228"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>TNBG-5602 is a newly synthesized compound with an isoquinoline structure. In the present study, we demonstrated the anticancer effect of TNBG-5602 in in-vitro and in-vivo models and investigated its possible anticancer mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The antiproliferation effect of TNBG-5602 in vitro was evaluated in human liver cancer cell line QGY-7701. The acute toxicity of TNBG-5602 was evaluated in mice. The anticancer activity of TNBG-5602 in vivo was assessed in a xenograft model of human liver cancer cell line QGY-7701.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The results of CCK-8 assay showed that TNBG-5602 can effectively inhibit the proliferation of liver cancer cells in vitro. The acute toxicity test in mice showed that the LD50 of TNBG-5602 was 172 mg\/kg. In a xenograft liver cancer model, TNBG-5602 could remarkably inhibit the growth of tumours. During in-vitro and in-vivo studies, we noted that TNBG-5602 could induce lipid accumulation in cancer cells and tissues. Further study indicated that the anticancer effect of TNBG-5602 may be exerted through activating peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) and downregulating proliferating cell nuclear antigen (PCNA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggested that TNBG-5602 might exert potent anticancer activity through increasing the expression of PPAR\u03b3.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13159","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T23:54:30Z","timestamp":1566777270000},"page":"1684-1694","source":"Crossref","is-referenced-by-count":13,"title":["TNBG-5602, a novel derivative of quinoxaline, inhibits liver cancer growth via upregulating peroxisome proliferator-activated receptor \u03b3 <i>in vitro<\/i> and <i>in vivo<\/i>"],"prefix":"10.1093","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-8760","authenticated-orcid":false,"given":"Xuelian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, School of Pharmacy, Chongqing Medical University , Chongqing,","place":["China"]},{"name":"Department of Pharmacy, Xinqiao Hospital , Chongqing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, School of Pharmacy, Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongjie","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, School of Pharmacy, Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Chongqing Medical University , Chongqing,","place":["China"]},{"name":"Key Laboratory for Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, School of Pharmacy, Chongqing Medical University , Chongqing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First Affiliate Hospital of Chongqing Medical University , 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