{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:04:05Z","timestamp":1772823845313,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province in China","doi-asserted-by":"publisher","award":["LY13H310005"],"award-info":[{"award-number":["LY13H310005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study is designed to investigate the effects and mechanisms of sinomenine (Sin) in stress load-induced heart failure in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used aortic constriction (AB) to cause pressure overload as our heart failure model. Sin was received in mice as the treatment group. Cardiac function and structural changes were detected using echocardiography. Heart\u2013lung mass ratios were measured. The serum levels of IL-10 and IL-17 proteins were detected by using ELISA, cardiac hypertrophy markers atrial natriuretic peptide (ANP), myocardial I and III collagen mRNA levels were detected by RT-PCR. Myocardial type I and III collagen protein levels were detected by Western blotting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Sin significantly improved stress load-induced heart failure (P &amp;lt; 0.05), reduced the heart\u2013lung mass ratio, ANP, collagen-I and -III mRNA and protein levels (P &amp;lt; 0.05); Sin can enhance the ratio of IL-10\/IL-17.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Sin may be a promising drug target to improve heart failure. Its role is related to reduce serum ANP levels, inhibit the mRNA and protein level of type I and III collagen and enhance the ratio of IL-10\/IL-17.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13181","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T03:55:01Z","timestamp":1574049301000},"page":"209-217","source":"Crossref","is-referenced-by-count":12,"title":["Sinomenine's protective role and mechanism in stress load-induced heart failure"],"prefix":"10.1093","volume":"72","author":[{"given":"Yan-Fei","family":"Fu","sequence":"first","affiliation":[{"name":"Grade 10 Pharmacy Undergraduate, School of Pharmacy, Zhejiang University of Technology , Hangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-9375","authenticated-orcid":false,"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Zhejiang University of Technology , Hangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine, Temple University , Philadelphia, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Zhejiang University of Technology , Hangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Zhejiang University of Technology , Hangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Hua","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Zhejiang University of Technology , Hangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou-Quan","family":"Tao","sequence":"additional","affiliation":[{"name":"Zhejiang Province People's Hospital Center Laboratory , Hangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"2024103012341981200_jphp13181-cit-0001","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0140-6736(18)31808-7","article-title":"Heart failure drug treatment","volume":"393","author":"Patrick","year":"2019","journal-title":"Lancet"},{"key":"2024103012341981200_jphp13181-cit-0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jchf.2017.08.023","article-title":"Anemia in heart failure: still relevant?","volume":"5","author":"Beverborg","year":"2018","journal-title":"JACC Heart 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