{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:52:19Z","timestamp":1785552739633,"version":"3.56.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National University of La Rioja","award":["27\/A269"],"award-info":[{"award-number":["27\/A269"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this work was to assess the preventive effect of an eicosapentaenoic acid\/docosahexaenoic acid-concentrate fish oil on neuropathic pain development and regenerative features of sciatic nerve in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In the present study, rats with chronic constriction injury (CCI) of the sciatic nerve and sham-operated ones received fish oil enriched in omega-3 fatty acids (0.36 or 0.72 g\/kg per day, oral) or saline solution for 21 days, with thermal hyperalgesia and mechanical allodynia being assessed before and 3, 7, 14 and 21 days after injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Fish oil enriched in omega-3 fatty acids (0.72 g\/kg) reversed thermal hyperalgesia and significantly reduced mechanical allodynia. In addition, \u03c9-3 treatment (0.72 g\/kg) promoted the recovery of the Sciatic Functional Index as well as restored axonal density and morphology, without the formation of neuroma in the injured sciatic nerves after 21 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We conclude that the fish oil enriched in omega-3 fatty acids administration relieves thermal hyperalgesia and mechanical allodynia effectively and also enhances the recovery process in rats with CCI of the sciatic nerve. These findings might contribute to new therapeutic approaches including omega-3 fatty acids in neuropathic pain treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13213","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T16:39:22Z","timestamp":1577378362000},"page":"437-447","source":"Crossref","is-referenced-by-count":29,"title":["Beneficial effects of fish oil enriched in omega-3 fatty acids on the development and maintenance of neuropathic pain"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-6794","authenticated-orcid":false,"given":"Santiago R","family":"Unda","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine, Department of Neurological Surgery, Molecular Neurosurgery Laboratory , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-8195","authenticated-orcid":false,"given":"Emilce A","family":"Villegas","sequence":"additional","affiliation":[{"name":"Biotechnology Institute, Research and Technological Innovation Center (CENIIT)-National University of La Rioja , La Rioja,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Toledo","sequence":"additional","affiliation":[{"name":"Biotechnology Institute, Research and Technological Innovation Center (CENIIT)-National University of La Rioja , La Rioja,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Asis Onell","sequence":"additional","affiliation":[{"name":"Medical Sciences Faculty, National University of C\u00f3rdoba , C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-5531","authenticated-orcid":false,"given":"Carlos H","family":"Laino","sequence":"additional","affiliation":[{"name":"Biotechnology Institute, Research and Technological Innovation Center (CENIIT)-National University of La Rioja , La Rioja,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"key":"2024103012343113700_jphp13213-cit-0001","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/j.pain.0000000000000492","article-title":"Neuropathic pain: an updated grading system for research and clinical practice","volume":"157","author":"Finnerup","year":"2016","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/s0304-3959(03)00006-x","article-title":"Translation of symptoms and signs into mechanisms in neuropathic pain","volume":"102","author":"Jensen","year":"2003","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0003","first-page":"9","article-title":"Tendencias de diagn\u00f3stico y tratamiento del dolor neurop\u00e1tico en M\u00e9xico","volume":"29","author":"Guevara-L\u00f3pez","year":"2006","journal-title":"Rev Mex Anest"},{"key":"2024103012343113700_jphp13213-cit-0004","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncpneuro0113","article-title":"Mechanisms of disease: neuropathic pain\u2013a clinical perspective","volume":"2","author":"Baron","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"2024103012343113700_jphp13213-cit-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(01)01302-4","article-title":"The clinical picture of neuropathic pain","volume":"429","author":"Jensen","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0006","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.mcna.2004.04.009","article-title":"Diabetic neuropathies","volume":"88","author":"Vinik","year":"2004","journal-title":"Med Clin North Am"},{"key":"2024103012343113700_jphp13213-cit-0007","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0304-3959(98)00138-9","article-title":"Assessment and treatment of neuropathic cancer pain following WHO guidelines","volume":"79","author":"Grond","year":"1999","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0008","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pain.2005.05.036","article-title":"Tactile allodynia in patients with postherpetic neuralgia: lack of change in skin blood flow upon dynamic stimulation","volume":"117","author":"Besson","year":"2005","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0009","first-page":"171","article-title":"HIV neuropathy: time for new therapies","volume":"1","author":"Brew","year":"2004","journal-title":"Drug Discov Today"},{"key":"2024103012343113700_jphp13213-cit-0010","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1213\/01.ANE.0000062826.70846.8D","article-title":"Defining neuropathic pain","volume":"97","author":"Backonja","year":"2003","journal-title":"Anesth Analg"},{"key":"2024103012343113700_jphp13213-cit-0011","doi-asserted-by":"crossref","first-page":"441","DOI":"10.7326\/0003-4819-140-8-200404200-00010","article-title":"Pain: moving from symptom control toward mechanism-specific pharmacologic management","volume":"140","author":"Woolf","year":"2004","journal-title":"Ann Intern Med"},{"key":"2024103012343113700_jphp13213-cit-0012","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S1474-4422(14)70102-4","article-title":"Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms","volume":"13","author":"Jensen","year":"2014","journal-title":"Lancet Neurol"},{"key":"2024103012343113700_jphp13213-cit-0013","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1212\/01.wnl.0000259085.61898.9e","article-title":"The impact of neuropathic pain on health-related quality of life: review and implications","volume":"68","author":"Jensen","year":"2007","journal-title":"Neurology"},{"key":"2024103012343113700_jphp13213-cit-0014","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pharmthera.2005.06.003","article-title":"Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms","volume":"109","author":"Ueda","year":"2006","journal-title":"Pharmacol Ther"},{"key":"2024103012343113700_jphp13213-cit-0015","first-page":"126","article-title":"Par\u00e1metros de pr\u00e1ctica para el manejo del dolor neurop\u00e1tico","volume":"58","author":"Guevara-L\u00f3pez","year":"2006","journal-title":"Rev Invest Clin"},{"key":"2024103012343113700_jphp13213-cit-0016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1503\/cmaj.060146","article-title":"Neuropathic pain: a practical guide for the clinician","volume":"175","author":"Gilron","year":"2006","journal-title":"CMAJ"},{"key":"2024103012343113700_jphp13213-cit-0017","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0140-6736(85)92024-0","article-title":"Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis","volume":"1","author":"Kremer","year":"1985","journal-title":"Lancet"},{"key":"2024103012343113700_jphp13213-cit-0018","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1073\/pnas.90.21.10345","article-title":"Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio","volume":"90","author":"Yehuda","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024103012343113700_jphp13213-cit-0019","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1097\/00000539-200104000-00042","article-title":"Soy-containing diet suppresses chronic neuropathic sensory disorders in rats","volume":"92","author":"Shir","year":"2001","journal-title":"Anesth Analg"},{"key":"2024103012343113700_jphp13213-cit-0020","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.pain.2005.01.010","article-title":"Analgesic effects of dietary caloric restriction in adult mice","volume":"114","author":"Hargraves","year":"2005","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0021","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/0091-3057(86)90519-8","article-title":"Effects of dietary fat on pain threshold, thermoregulation and motor activity in rats","volume":"6","author":"Yehuda","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"2024103012343113700_jphp13213-cit-0022","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.phrs.2011.02.004","article-title":"Fish oil concentrate delays sensitivity to thermal nociception in mice","volume":"63","author":"Veigas","year":"2011","journal-title":"Pharmacol Res"},{"key":"2024103012343113700_jphp13213-cit-0023","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pain.2004.07.006","article-title":"Dietary fat and protein interact in suppressing neuropathic pain-related disorders following a partial sciatic ligation injury in rats","volume":"111","author":"Perez","year":"2004","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0024","first-page":"92","article-title":"Lipids, sterols, and their metabolites","volume-title":"Modern Nutrition in Health and Disease","author":"Jones","year":"2006","edition":"10"},{"key":"2024103012343113700_jphp13213-cit-0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40798-018-0176-6","article-title":"Nutritional and supplementation strategies to prevent and attenuate exercise-induced muscle damage: a brief review","volume":"5","author":"Harty","year":"2019","journal-title":"Sports Med Open"},{"key":"2024103012343113700_jphp13213-cit-0026","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pain.2007.01.020","article-title":"A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain","volume":"129","author":"Goldberg","year":"2007","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0027","first-page":"689","article-title":"Does dietary supplementation of cod liver oil mitigate musculoskeletal pain?","volume":"50","author":"Eriksen","year":"1996","journal-title":"Eur J Clin Nutr"},{"issue":"Suppl. 1","key":"2024103012343113700_jphp13213-cit-0028","doi-asserted-by":"crossref","first-page":"339S","DOI":"10.1093\/ajcn\/71.1.339S","article-title":"Polyunsaturated fatty acids and inflammatory bowel disease","volume":"71","author":"Belluzzi","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"2024103012343113700_jphp13213-cit-0029","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0002-9378(96)70681-6","article-title":"Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents","volume":"174","author":"Harel","year":"1966","journal-title":"Am J Obstet Gynecol"},{"key":"2024103012343113700_jphp13213-cit-0030","doi-asserted-by":"crossref","first-page":"111992","DOI":"10.1016\/j.bbr.2019.111992","article-title":"Acute antinociceptive effect of fish oil or its major compounds, eicosapentaenoic and docosahexaenoic acids on diabetic neuropathic pain depends on opioid system activation","volume":"372","author":"Redivo","year":"2019","journal-title":"Behav Brain Res"},{"key":"2024103012343113700_jphp13213-cit-0031","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/221028901708010052","article-title":"Innovations in pain management: morphine combined with omega-3 fatty acids","volume":"8","author":"Laino","year":"2017","journal-title":"Open Conf Proc J"},{"key":"2024103012343113700_jphp13213-cit-0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2009.00801.x","article-title":"Animal models of neuropathic pain","volume":"25","author":"Jaggi","year":"2011","journal-title":"Fundam Clin Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0033","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/jphp.12416","article-title":"Analgesia enhancement and prevention of tolerance to morphine: beneficial effects of combined therapy with omega 3 fatty acids","volume":"67","author":"Escudero","year":"2015","journal-title":"J Pharm Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0034","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"2024103012343113700_jphp13213-cit-0035","first-page":"229","article-title":"Paradoxical effect of minocycline on established neuropathic pain in rat","volume":"16","author":"Zarei","year":"2017","journal-title":"EXCLI J"},{"key":"2024103012343113700_jphp13213-cit-0036","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jpain.2009.01.325","article-title":"Differentiating thermal allodynia and hyperalgesia using dynamic hot and cold plate in rodents","volume":"10","author":"Yalcin","year":"2009","journal-title":"J Pain"},{"key":"2024103012343113700_jphp13213-cit-0037","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"2024103012343113700_jphp13213-cit-0038","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3171\/jns.2001.95.4.0694","article-title":"Laser, fibrin glue, or suture repair of peripheral nerves: a comparative functional, histological, and morphometric study in the rat sciatic nerve","volume":"95","author":"Menovsky","year":"2001","journal-title":"J Neurosurg"},{"key":"2024103012343113700_jphp13213-cit-0039","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1590\/S0004-282X2011000300019","article-title":"Effects of eliminating tension by means of epineural stitches: a comparative electrophysiological and histomorphometrical study using different suture techniques in an animal model","volume":"69","author":"Bustamante","year":"2011","journal-title":"Arq Neuropsiquiatr"},{"key":"2024103012343113700_jphp13213-cit-0040","first-page":"11","article-title":"Estudio prospectivo de microcirug\u00eda experimental en neurorrafias con tensi\u00f3n","volume":"29","author":"Bustamante","year":"2015","journal-title":"Rev Arg Neuroc"},{"key":"2024103012343113700_jphp13213-cit-0041","first-page":"1780","article-title":"Nogo-A antibody treatment enhances neuron recovery after sciatic nerve transection in rats","volume":"21","author":"Zhang","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2024103012343113700_jphp13213-cit-0042","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1152\/jn.01088.2012","article-title":"Dynamic effects of TNF-\u03b1 on synaptic transmission in mice over time following sciatic nerve chronic constriction injury","volume":"110","author":"Zhang","year":"2013","journal-title":"J Neurophysiol"},{"key":"2024103012343113700_jphp13213-cit-0043","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuroscience.2010.08.067","article-title":"Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models","volume":"171","author":"Marinelli","year":"2010","journal-title":"Neuroscience"},{"key":"2024103012343113700_jphp13213-cit-0044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2009.09.030","article-title":"Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain","volume":"623","author":"Mika","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2014.11.039","article-title":"The involvement of the TRPA1 receptor in a mouse model of sympathetically maintained neuropathic pain","volume":"7","author":"Pinheiro","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0046","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1523\/JNEUROSCI.3371-11.2012","article-title":"Improved outcome after peripheral nerve injury in mice with increased levels of endogenous omega-3 polyunsaturated fatty acids","volume":"32","author":"Gladman","year":"2012","journal-title":"J Neurosci"},{"key":"2024103012343113700_jphp13213-cit-0047","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3389\/fphar.2017.00723","article-title":"Long-chain omega-3 fatty acids supplementation accelerates nerve regeneration and prevents neuropathic pain behavior in mice","volume":"17","author":"Silva","year":"2017","journal-title":"Front Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0048","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10517-014-2428-x","article-title":"Specific features of analgesic effect of docosahexaenoic acid in rats with neuropathic pain syndrome","volume":"156","author":"Dyuizen","year":"2014","journal-title":"Bull Exp Biol Med"},{"key":"2024103012343113700_jphp13213-cit-0049","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.acthis.2015.07.001","article-title":"Analgetic effect of docosahexaenoic acid is mediated by modulating the microglia activity in the dorsal root ganglia in a rat model of neuropathic pain","volume":"117","author":"Manzhulo","year":"2015","journal-title":"Acta Histochem"},{"key":"2024103012343113700_jphp13213-cit-0050","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jneuroim.2016.07.015","article-title":"Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy","volume":"15","author":"Manzhulo","year":"2016","journal-title":"J Neuroimmunol"},{"key":"2024103012343113700_jphp13213-cit-0051","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jnutbio.2015.11.009","article-title":"Docosahexaenoic acid confers analgesic effects after median nerve injury via inhibition of c-Jun N-terminal kinase activation in microglia","volume":"29","author":"Huang","year":"2016","journal-title":"J Nutr Biochem"},{"key":"2024103012343113700_jphp13213-cit-0052","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2011.11.012","article-title":"Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system","volume":"1432","author":"Nakamoto","year":"2012","journal-title":"Brain Res"},{"key":"2024103012343113700_jphp13213-cit-0053","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1248\/yakushi.12-00278-2","article-title":"Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception","volume":"133","author":"Nishinaka","year":"2013","journal-title":"Yakugaku Zasshi"},{"key":"2024103012343113700_jphp13213-cit-0054","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1213\/01.ANE.0000158469.11775.52","article-title":"Dietary omega-3 fatty acids may be associated with increased neuropathic pain in nerve-injured rats","volume":"101","author":"Perez","year":"2005","journal-title":"Anesth Analg"},{"key":"2024103012343113700_jphp13213-cit-0055","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/micr.20685","article-title":"Functional assessment after sciatic nerve injury in a rat model","volume":"29","author":"Dinh","year":"2009","journal-title":"Microsurgery"},{"key":"2024103012343113700_jphp13213-cit-0056","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jneumeth.2014.01.020","article-title":"Sciatic nerve injury: a simple and subtle model for investigating many aspects of nervous system damage and recovery","volume":"30","author":"Savastano","year":"2014","journal-title":"J Neurosci Methods"},{"key":"2024103012343113700_jphp13213-cit-0057","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1302\/2058-5241.2.160071","article-title":"Nerve injuries of the upper extremity and hand","volume":"2","author":"Dahlin","year":"2017","journal-title":"EFORT Open Rev"},{"key":"2024103012343113700_jphp13213-cit-0058","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pathophys.2017.04.001","article-title":"Pro and anti-inflammatory cytokine levels (TNF-\u03b1, IL-1\u03b2, IL-6 and IL-10) in rat model of neuroma","volume":"24","author":"Khan","year":"2017","journal-title":"Pathophysiology"},{"key":"2024103012343113700_jphp13213-cit-0059","first-page":"52","article-title":"Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas","volume":"21","author":"Bird","year":"2013","journal-title":"Mol Pain"},{"key":"2024103012343113700_jphp13213-cit-0060","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"2024103012343113700_jphp13213-cit-0061","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 fatty acids and inflammatory processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"2024103012343113700_jphp13213-cit-0062","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.biocel.2006.06.014","article-title":"Docosahexaenoic acid (omega-3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells","volume":"38","author":"Isbilen","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"2024103012343113700_jphp13213-cit-0063","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s00424-014-1573-4","article-title":"Suppression of PPAR\u03b2, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities","volume":"467","author":"Wannous","year":"2015","journal-title":"Pflugers Arch"},{"key":"2024103012343113700_jphp13213-cit-0064","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jcms.2017.05.004","article-title":"Possible effects of some agents on the injured nerve in obese rats: a stereological and electron microscopic study","volume":"45","author":"Onger","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"2024103012343113700_jphp13213-cit-0065","first-page":"944","article-title":"Histomorphometric and ultrastructural evaluation of long-term alpha lipoic acid and vitamin B12 use after experimental sciatic nerve injury in rats","volume":"26","author":"Arikan","year":"2016","journal-title":"Turk Neurosurg"},{"key":"2024103012343113700_jphp13213-cit-0066","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00687678","article-title":"Long-term endoneurial changes after nerve transection","volume":"76","author":"Roytta","year":"1988","journal-title":"Acta Neuropathol"},{"key":"2024103012343113700_jphp13213-cit-0067","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nm.2123","article-title":"Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions","volume":"16","author":"Xu","year":"2010","journal-title":"Nat Med"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.13213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jphp.13213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jphp.13213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/72\/3\/437\/60225633\/jphp13213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/72\/3\/437\/60225633\/jphp13213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:53:18Z","timestamp":1730310798000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/72\/3\/437\/6122102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,1]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.13213","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2020,3,1]]}}}