{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:49:15Z","timestamp":1790034555507,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Key projects of Provincial Natural Science Foundation of Universities in Anhui","award":["KJ2018A0662"],"award-info":[{"award-number":["KJ2018A0662"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Evodiamine (Evo) possesses strong anti-inflammatory activity. In this study, we determine the antiarthritic effect of Evo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Evo was administered to rats with adjuvant-induced arthritis (AA). We evaluated arthritis symptoms &amp; histopathological changes and measured inflammatory cell infiltration, pro-inflammatory cytokine production and Th17 &amp; Treg percentages in arthritic rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Evo significantly improved the clinical signs of AA in rats, including decreases in paw swelling, the polyarthritis index and the number of swollen paw joints. Based on the histopathological analysis, Evo improved synovial inflammation and bone injury by inhibiting inflammatory cell infiltration, synoviocyte proliferation, pannus formation and cartilage erosion. Furthermore, the numbers of synovial CD3+ or CD68+ inflammatory cells were reduced, and the elevated levels of tumour necrosis factor-\u03b1, interleukin-1\u03b2 (IL-1\u03b2) and IL-6 were restored to control levels by the Evo treatment. In addition, Evo therapy regulated the abnormal differentiation of Treg and Th17 cells, decreasing IL-17 production and increasing IL-10 levels. Finally, Evo inhibited Stat3 phosphorylation and induced Stat5 phosphorylation in rats with AA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Based on our results, Evo is a promising antiarthritic agent, potentially due to its inhibitory effect on synovial inflammation and regulatory effects on Treg and Th17 differentiation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13238","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T01:04:34Z","timestamp":1581642274000},"page":"798-806","source":"Crossref","is-referenced-by-count":27,"title":["Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17\/Treg balance"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-0328","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-tian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-sheng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"2024103012352629500_jphp13238-cit-0001","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"2024103012352629500_jphp13238-cit-0002","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.apmr.2013.10.032","article-title":"Incidence, prevalence, costs, and impact on disability of common conditions requiring rehabilitation in the United States: stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, osteoarthritis, rheumatoid arthritis, limb loss, and back pain","volume":"95","author":"Ma","year":"2014","journal-title":"Arch Phys Med Rehabil"},{"key":"2024103012352629500_jphp13238-cit-0003","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/art.23177","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. 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