{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:20:56Z","timestamp":1789392056650,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>A\u00e7a\u00ed (Euterpe oleracea) is widely consumed in Brazil and known for its numerous health-beneficial properties. This study investigated the gastroprotective potential of the dried a\u00e7a\u00ed berries extract (DAE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Dried a\u00e7a\u00ed berries extract effect was evaluated against ethanol-induced gastric ulcer in rats. Its ability to regulate antioxidant defenses and reduce inflammatory parameters was evaluated in the ulcerated tissues. The scavenger capability of DAE was assessed by DPPH assay, and phytochemical composition was accessed by UHPLC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The extract showed radical scavenger activity in vitro (IC50 = 210 \u00b5g\/ml) and gastroprotective effect in vivo, reducing the ulcerated area by 83%, 67% and 48% at doses of 30 and 100 mg\/kg (p.o) and 3 mg\/kg (i.p), respectively, compared with vehicle group. Besides, DAE (100 mg\/kg, p.o) increased the GSH content and GST activity in ulcerated mucosa. Animals treated with DAE showed normalized levels of SOD activity, elevated CAT activity and decreased MPO activity, as well as reduced TNF-\u03b1 levels, compared with vehicle group. Peonidin-3-glucoside, peonidin-3-rutinoside, cyanidin-3,5-hexoside-pentoside, cyaniding-3-glucoside, pelargonidin-3-glucoside and pelargonidin-3-rutinoside were identified in DAE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings suggest that DAE reduces the inflammation and maintains the oxidative balance of gastric mucosa, therefore being a promising natural resource or useful nutraceutical to protect gastric mucosa.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13290","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T06:10:51Z","timestamp":1589955051000},"page":"1239-1244","source":"Crossref","is-referenced-by-count":11,"title":["A\u00e7a\u00ed berries (<i>Euterpe oleracea<\/i> Mart.) dried extract improves ethanol-induced ulcer in rats"],"prefix":"10.1093","volume":"72","author":[{"given":"Benhur Judah","family":"Cury","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-6166","authenticated-orcid":false,"given":"Thaise","family":"Boeing","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincon Bordignon","family":"Somensi","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Nath\u00e1lia Bolda","family":"Mariano","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-7290","authenticated-orcid":false,"given":"Sergio Faloni","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]},{"name":"CBIOS, Research Center for Biosciences and Health Technologies, Universidade Lus\u00f3fona , Lisboa,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Breviglieri","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]},{"name":"Faculdade de Medicina \u2013 Est\u00e1cio de Jaragu\u00e1 , Jaragu\u00e1 do Sul, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Klein-Junior","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed \u2013 UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-7301","authenticated-orcid":false,"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias 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