{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:01:58Z","timestamp":1787770918329,"version":"build-2784847793"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973003"],"award-info":[{"award-number":["30973003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901993"],"award-info":[{"award-number":["30901993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018612","name":"Jiangsu Province's Key Provincial Talents Program","doi-asserted-by":"crossref","award":["QNRC 2016530"],"award-info":[{"award-number":["QNRC 2016530"]}],"id":[{"id":"10.13039\/501100018612","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was undertaken to reveal therapeutic effects and the preliminary mechanism of Chinese medicine formula Qianlie Tongli decoction (QTD) in chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 50 male C57BL\/6 mice were randomly divided into five groups. All groups except the control group were injected subcutaneously T2 peptide emulsion, which induced the CP\/CPPS model. After the induction of CP\/CPPS, the model group was given normal saline by oral gavage while low-dose, medium-dose and high-dose groups were treated with Chinese medicine formula. Micturition habits and pain behaviour of mice were analysed for each group. Haematoxylin and eosin (H&amp;E) staining was used to investigate prostate inflammation. The serum level of tumour necrosis factor-\u03b1 (TNF-\u03b1) was measured by enzyme-linked immunosorbent assay (ELISA) kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Chinese medicine formula significantly reduced the number of urine spots and improved pain response frequency in the medium-dose and high-dose group. The high-dose group showed reduced considerably inflammatory lesion and inflammatory cell infiltration than the low-dose and medium-dose groups. Serum levels of TNF-\u03b1 in the high-dose group were significantly reduced compared with the model group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results demonstrated the therapeutic effects of Qianlie Tongli decoction in CP\/CPPS mice by analysing clinically relevant symptoms (urinary tract system, pelvic pain and prostate inflammation) and preliminarily explored the inflammatory-related treatment mechanisms by measuring TNF-\u03b1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.13325","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T10:20:03Z","timestamp":1594376403000},"page":"1436-1444","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic effects of Qianlie Tongli decoction on chronic prostatitis\/chronic pelvic pain syndrome induced by peptide T2 in mice"],"prefix":"10.1093","volume":"72","author":[{"given":"Xingxing","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-9266","authenticated-orcid":false,"given":"Muhammad","family":"Naveed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]},{"name":"School of Pharmacy, Nanjing Medical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-9594","authenticated-orcid":false,"given":"Mirza Muhammad Faran Ashraf","family":"Baig","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-4619","authenticated-orcid":false,"given":"Reyaj","family":"Mikrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Ahmad","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing Medical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junaid","family":"Wazir","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu Province,","place":["China"]},{"name":"Department of Surgery, Nanjing Shuiximen Hospital , Nanjing, Jiangsu Province,","place":["China"]},{"name":"Zhongda Hospital, Affiliated with Southeast University , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jiangsu Jiankang Vocational College , Nanjing, Jiangsu Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"2024103012343910700_jphp13325-cit-0001","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/pcan.2016.8","article-title":"Chronic prostatitis\/chronic pelvic pain syndrome: a review of evaluation and therapy","volume":"19","author":"Polackwich","year":"2016","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"2024103012343910700_jphp13325-cit-0002","first-page":"1802","article-title":"Chronic bacterial prostatitis and chronic pelvic pain syndrome","volume":"2015","author":"Bowen","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"2024103012343910700_jphp13325-cit-0003","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1525-1497.2001.01223.x","article-title":"Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network","volume":"16","author":"McNaughton Collins","year":"2001","journal-title":"J Gen Intern Med"},{"key":"2024103012343910700_jphp13325-cit-0004","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/01.ju.0000082252.49374.e9","article-title":"Leukocytes and bacteria in men with chronic prostatitis\/chronic pelvic pain syndrome compared to asymptomatic controls","volume":"170","author":"Nickel","year":"2003","journal-title":"J Urol"},{"key":"2024103012343910700_jphp13325-cit-0005","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/bju.13101","article-title":"Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis\/chronic pelvic pain syndrome: a consensus guideline","volume":"116","author":"Rees","year":"2015","journal-title":"BJU Int"},{"key":"2024103012343910700_jphp13325-cit-0006","first-page":"75","article-title":"Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy","volume":"10","author":"Paulis","year":"2018","journal-title":"Res Rep Urol"},{"key":"2024103012343910700_jphp13325-cit-0007","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.06.139","article-title":"Role of oxidative stress in pathology of chronic prostatitis\/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress","volume":"106","author":"Ihsan","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"2024103012343910700_jphp13325-cit-0008","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/pros.23684","article-title":"Identification and preliminary study of immunogens involved in autoimmune prostatitis in human males","volume":"78","author":"Lu","year":"2018","journal-title":"Prostate"},{"key":"2024103012343910700_jphp13325-cit-0009","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jri.2016.09.004","article-title":"Association of anti-sperm antibodies with chronic prostatitis: a systematic review and meta-analysis","volume":"118","author":"Jiang","year":"2016","journal-title":"J Reprod Immunol"},{"key":"2024103012343910700_jphp13325-cit-0010","doi-asserted-by":"crossref","first-page":"e41941","DOI":"10.1371\/journal.pone.0041941","article-title":"Therapeutic intervention for chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS): a systematic review and meta-analysis","volume":"7","author":"Cohen","year":"2012","journal-title":"PLoS One"},{"key":"2024103012343910700_jphp13325-cit-0011","first-page":"290","article-title":"Common questions about chronic prostatitis","volume":"93","author":"Holt","year":"2016","journal-title":"Am Fam Physician"},{"key":"2024103012343910700_jphp13325-cit-0012","doi-asserted-by":"crossref","first-page":"172429","DOI":"10.1016\/j.ejphar.2019.172429","article-title":"Interventions to chronic prostatitis\/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?","volume":"857","author":"Appiya Santharam","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"2024103012343910700_jphp13325-cit-0013","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrurol.2009.45","article-title":"Prostatitis: no benefit of alpha-blockers for chronic prostatitis","volume":"6","author":"Wagenlehner","year":"2009","journal-title":"Nat Rev Urol"},{"key":"2024103012343910700_jphp13325-cit-0014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ncpuro0438","article-title":"Traditional therapy for chronic pelvic pain does not work: what do we do now?","volume":"3","author":"Anderson","year":"2006","journal-title":"Nat Clin Pract Urol"},{"key":"2024103012343910700_jphp13325-cit-0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrurol.2014.63","article-title":"Immune mediators of chronic pelvic pain syndrome","volume":"11","author":"Murphy","year":"2014","journal-title":"Nat Rev Urol"},{"key":"2024103012343910700_jphp13325-cit-0016","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1155\/2017\/7424307","article-title":"Traditional Chinese Medicine protects against cytokine production as the potential immunosuppressive agents in atherosclerosis","volume":"2017","author":"Ren","year":"2017","journal-title":"J Immunol Res"},{"key":"2024103012343910700_jphp13325-cit-0017","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1089\/jmf.2017.4088","article-title":"Anti-inflammatory activity of epimedium brevicornu maxim ethanol extract","volume":"21","author":"Huang","year":"2018","journal-title":"J Med Food"},{"key":"2024103012343910700_jphp13325-cit-0018","first-page":"1023","article-title":"The effect of Zhejiang Fritillaria thunbergii against immunological CP\/CPPS","volume":"29","author":"Xia","year":"2011","journal-title":"Chin Arch Tradit Med"},{"key":"2024103012343910700_jphp13325-cit-0019","first-page":"389","article-title":"Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects","volume":"36","author":"Li","year":"2018","journal-title":"J Pharm Pract"},{"key":"2024103012343910700_jphp13325-cit-0020","first-page":"1709","article-title":"A metabolomic study on the intervention effect of phellodenron Amurense Rupr. alkaloid protects against chronic nonbacterial prostatitis in rats","volume":"18","author":"Hui","year":"2016","journal-title":"Modern Tradit Chin Med Mater Med World Sci Tech"},{"key":"2024103012343910700_jphp13325-cit-0021","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/2225-4110.119708","article-title":"Origin of innate immune responses: revelation of food and medicinal applications","volume":"3","author":"Cooper","year":"2013","journal-title":"J Tradit Complement Med"},{"key":"2024103012343910700_jphp13325-cit-0022","first-page":"1116","article-title":"Effect of Qianlie Tongli decoction on expression of proinflammatory cytokine genes of chronic abacterial prostatitis model rats","volume":"49","author":"Zhou","year":"2008","journal-title":"J Tradit Chin Med"},{"key":"2024103012343910700_jphp13325-cit-0023","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.biopha.2018.10.010","article-title":"Experimental rodent models of chronic prostatitis and evaluation criteria","volume":"108","author":"Wang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"2024103012343910700_jphp13325-cit-0024","doi-asserted-by":"crossref","first-page":"e12922","DOI":"10.1111\/and.12922","article-title":"Establishment of experimental autoimmune prostatitis model by T2 peptide in aluminium hydroxide adjuvant","volume":"50","author":"Zhang","year":"2018","journal-title":"Andrologia"},{"key":"2024103012343910700_jphp13325-cit-0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.imlet.2017.05.008","article-title":"A novel mouse model of chronic prostatitis\/chronic pelvic pain syndrome induced by immunization of special peptide fragment with aluminum hydroxide adjuvant","volume":"187","author":"Khan","year":"2017","journal-title":"Immunol Lett"},{"key":"2024103012343910700_jphp13325-cit-0026","doi-asserted-by":"crossref","first-page":"F1274","DOI":"10.1152\/ajprenal.00318.2017","article-title":"Evaluating the voiding spot assay in mice: a simple method with complex environmental interactions","volume":"313","author":"Chen","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"2024103012343910700_jphp13325-cit-0027","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10753-019-00968-5","article-title":"Novel treatment of experimental autoimmune prostatitis by nanoparticle-conjugated autoantigen peptide T2","volume":"42","author":"Cheng","year":"2019","journal-title":"Inflammation"},{"key":"2024103012343910700_jphp13325-cit-0028","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4081\/aiua.2018.4.260","article-title":"The role of nutraceutical medications in men with non bacterial chronic prostatitis and chronic pelvic pain syndrome: a prospective non blinded study utilizing flower pollen extracts versus bioflavonoids","volume":"90","author":"Maurizi","year":"2018","journal-title":"Arch Ital Urol Androl"},{"key":"2024103012343910700_jphp13325-cit-0029","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bcp.2017.06.123","article-title":"Major achievements of evidence-based traditional Chinese medicine in treating major diseases","volume":"139","author":"Chao","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"2024103012343910700_jphp13325-cit-0030","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.2147\/PPA.S108699","article-title":"Efficacy and safety of Chinese herbal medicine for chronic prostatitis associated with damp-heat and blood-stasis syndromes: a meta-analysis and literature review","volume":"10","author":"Wang","year":"2016","journal-title":"Patient Prefer Adherence"},{"key":"2024103012343910700_jphp13325-cit-0031","first-page":"363","article-title":"Common TCM syndrome pattern of chronic pelvic pain syndrome relates to plasma substance p and beta endorphin","volume":"20","author":"Ma","year":"2014","journal-title":"Zhonghua Nan Ke Xue"},{"key":"2024103012343910700_jphp13325-cit-0032","first-page":"41","article-title":"Multiple factors logistic regression analysis on the basic syndromes related factors in patients with chronic prostatitis","volume":"31","author":"Li","year":"2011","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"2024103012343910700_jphp13325-cit-0033","first-page":"989","article-title":"Clinical study on treatment of chronic prostatitis\/chronic pelvic pain syndrome by three different TCM principles","volume":"27","author":"Zhang","year":"2007","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"2024103012343910700_jphp13325-cit-0034","first-page":"965","volume-title":"Chinese Pharmacopoeia (2015 Edition), Section 1","author":"Chinese Pharmacopoeia Commission","year":"2015"},{"key":"2024103012343910700_jphp13325-cit-0035","first-page":"409","article-title":"TLC identification for nankang tablets","volume":"7","author":"Yan","year":"2002","journal-title":"Shizhen Guo Yi Guo Yao"},{"key":"2024103012343910700_jphp13325-cit-0036","first-page":"1645","article-title":"Determination of Icariine in Qianlietong Tablets by HPLC","volume":"21","author":"Dong","year":"2008","journal-title":"China Pharmacy"},{"key":"2024103012343910700_jphp13325-cit-0037","first-page":"161","article-title":"Determination of berberine hydrochloride in Qianlietong Granules by HPLC","volume":"28","author":"Xueyuan","year":"2012","journal-title":"Pharm J Chin People's Liberation Army"},{"key":"2024103012343910700_jphp13325-cit-0038","volume-title":"Compendium of Materia Medica, classics of traditional Chinese medicine, Ming Dynasty","author":"Shizhen"},{"key":"2024103012343910700_jphp13325-cit-0039","volume-title":"ShenNong's herbal classic of Materia Medica, Qing Dynasty","author":"Guanguang"},{"key":"2024103012343910700_jphp13325-cit-0040","first-page":"62","article-title":"Acupoint injection of Shuxuetong for chronic prostatitis \/ chronic pelvic pain syndrome complicated by premature ejaculation","volume":"25","author":"Sun","year":"2019","journal-title":"Zhonghua Nan Ke Xue"},{"key":"2024103012343910700_jphp13325-cit-0041","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/jssc.201801018","article-title":"A LC-MS\/MS method for simultaneous determination of seven alkaloids in rat plasma after oral administration of Phellodendri chinensis cortex extract and its application to a pharmacokinetic study","volume":"42","author":"Wang","year":"2019","journal-title":"J Sep Sci"},{"key":"2024103012343910700_jphp13325-cit-0042","doi-asserted-by":"crossref","first-page":"4531092","DOI":"10.1155\/2019\/4531092","article-title":"Chromatographic fingerprint and quantitative analysis of commercial Pheretima aspergillum (Guang Dilong) and its adulterants by UPLC-DAD","volume":"2019","author":"Sun","year":"2019","journal-title":"Int J Anal Chem"},{"key":"2024103012343910700_jphp13325-cit-0043","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1002\/jssc.201600356","article-title":"Multiple analytical methods for identification and quality evaluation of Fritillariae Thunbergii Bulbus based on biological single molecules by high-performance liquid chromatography","volume":"39","author":"Zhang","year":"2016","journal-title":"J Sep Sci"},{"key":"2024103012343910700_jphp13325-cit-0044","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jpba.2018.07.023","article-title":"Simultaneous determination of fourteen compounds of Hedyotis diffusa Willd extract in rats by UHPLC-MS\/MS method: application to pharmacokinetics and tissue distribution study","volume":"159","author":"Chen","year":"2018","journal-title":"J Pharm Biomed Anal"},{"key":"2024103012343910700_jphp13325-cit-0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/pca.1018","article-title":"Simultaneous quantitation of five flavonoid glycosides in Herba Epimedii by high-performance liquid chromatography-tandem mass spectrometry","volume":"19","author":"Islam","year":"2008","journal-title":"Phytochem Anal"},{"key":"2024103012343910700_jphp13325-cit-0046","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","article-title":"Traditional Chinese medicine and immune regulation","volume":"44","author":"Ma","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"2024103012343910700_jphp13325-cit-0047","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1271\/bbb.110076","article-title":"Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells","volume":"75","author":"Cho","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"2024103012343910700_jphp13325-cit-0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3412074","article-title":"Overcoming P-Glycoprotein-mediated multidrug resistance in colorectal cancer: potential reversal agents among herbal medicines","volume":"2018","author":"Lee","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"2024103012343910700_jphp13325-cit-0049","doi-asserted-by":"crossref","first-page":"27252","DOI":"10.3390\/ijms161126021","article-title":"Chemical profiles and protective effect of Hedyotis diffusa Willd in lipopolysaccharide-induced renal inflammation mice","volume":"16","author":"Ye","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2024103012343910700_jphp13325-cit-0050","first-page":"50","article-title":"The effect of icariin on immunity and its potential application","volume":"7","author":"Shen","year":"2018","journal-title":"Am J Clin Exp Immunol"},{"key":"2024103012343910700_jphp13325-cit-0051","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biopha.2016.02.015","article-title":"Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model","volume":"79","author":"Liu","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"2024103012343910700_jphp13325-cit-0052","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-5347(05)67497-6","article-title":"IL-1\u03b2 and TNF-\u03b1 in prostatic secretions are indicators in the evaluation of men with chronic prostatitis","volume":"164","author":"Nadler","year":"2000","journal-title":"J Urol"},{"key":"2024103012343910700_jphp13325-cit-0053","doi-asserted-by":"crossref","first-page":"e13435","DOI":"10.1111\/and.13435","article-title":"Morphological reseach on expression of inflammatory mediators in murine models of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) induced by T2 antigen","volume":"51","author":"Wang","year":"2019","journal-title":"Andrologia"},{"key":"2024103012343910700_jphp13325-cit-0054","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/pros.22580","article-title":"Evidences of the inflammasome pathway in chronic prostatitis and chronic pelvic pain syndrome in an animal model","volume":"73","author":"Chen","year":"2013","journal-title":"Prostate"},{"key":"2024103012343910700_jphp13325-cit-0055","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/bja\/aew376","article-title":"The inflammasome as a target for pain therapy","volume":"117","author":"Zhang","year":"2016","journal-title":"Br J Anaesth"},{"key":"2024103012343910700_jphp13325-cit-0056","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.ejpain.2008.02.003","article-title":"Role of cytokines in mediating mechanical hypernociception in a model of delayed-type hypersensitivity in mice","volume":"12","author":"Cunha","year":"2008","journal-title":"Eur J Pain"},{"key":"2024103012343910700_jphp13325-cit-0057","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pain.2010.06.005","article-title":"TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury","volume":"151","author":"He","year":"2010","journal-title":"Pain"},{"key":"2024103012343910700_jphp13325-cit-0058","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1358\/dot.2013.49.7.1990152","article-title":"Contemporary treatment options for chronic prostatitis\/chronic pelvic pain syndrome","volume":"49","author":"Ismail","year":"2013","journal-title":"Drugs Today (Barc)"},{"key":"2024103012343910700_jphp13325-cit-0059","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00345-013-1075-6","article-title":"Classification and treatment of men with chronic prostatitis\/chronic pelvic pain syndrome using the UPOINT system","volume":"31","author":"Shoskes","year":"2013","journal-title":"World J Urol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.13325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jphp.13325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jphp.13325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/72\/10\/1436\/60225752\/jphp13325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/72\/10\/1436\/60225752\/jphp13325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:54:39Z","timestamp":1730296479000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/72\/10\/1436\/6132710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":59,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,1]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.13325","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202004.0301.v2","asserted-by":"object"},{"id-type":"doi","id":"10.20944\/preprints202004.0301.v1","asserted-by":"object"}]},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,10,1]]}}}