{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:57:48Z","timestamp":1772647068539,"version":"3.50.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The present study aimed mainly to demonstrate the effect of the antihistamine azelastine (AZ) and Angiotensin receptor blocker ( ARB), represented by losartan (LOS) either alone or in combined form on certain metabolic aspects, endothelial dysfunction and platelets activation markers in diabetic hyperlipidemic rat model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Rats were randomly classified to five groups: One group fed normal chow diet (NC). Four groups received alloxan and CCT-diet. One group received no treatment (DHC while the other three groups received AZ, LOS and their combination form, respectively for 8 weeks. Serum and tissue samples were collected for biochemical and histological evaluations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>DHC rats demonstrated significant hyperglycaemia, dyslipidemia, disturbances in endothelial and platelet activation markers. AZ or LOS administration demonstrated hypoglycaemic and hypolipidemic effects. VCAM-1 and sE-selectin (Endothelial function markers) along with CD63 (Platelet activation marker) showed significant decrease as compared to control group. AZ administration exerted little prominent effects than that of LOS, while their combination demonstrated remarkable changes compared to monotherapy. Histopathological findings were in agreement to certain extent with the biomarkers results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13363","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T13:14:22Z","timestamp":1599138862000},"page":"1812-1821","source":"Crossref","is-referenced-by-count":4,"title":["Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-7563","authenticated-orcid":false,"given":"Mohamed M","family":"Elseweidy","sequence":"first","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, Zagazig University , Zagazig,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gehad M","family":"Elnagar","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, Zagazig University , Zagazig,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"M.Elsawy","sequence":"additional","affiliation":[{"name":"Chemistry Department (Biochemistry Division), Faculty of Pharmacy, Zagazig University , Zagazig,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelmoneim A","family":"Ali","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of veterinary medicine, Zagazig university , Zagazig,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabila","family":"Zein","sequence":"additional","affiliation":[{"name":"Chemistry Department (Biochemistry Division), Faculty of Pharmacy, Zagazig University , Zagazig,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"2024110604202460200_jphp13363-cit-0001","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/FJC.0000000000000522","article-title":"P-407-induced mouse model of dose-controlled hyperlipidemia and atherosclerosis: 25 Years Later","volume":"70","author":"Johnston","year":"2017","journal-title":"J Cardiovasc Pharmacol"},{"key":"2024110604202460200_jphp13363-cit-0002","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.atherosclerosissup.2018.04.196","article-title":"Impact of lingonberry supplementation on high-fat diet-induced metabolic syndrome and hyperlipidemia","volume":"32","author":"Hewage","year":"2018","journal-title":"Atheroscler Suppl"},{"key":"2024110604202460200_jphp13363-cit-0003","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.2515","article-title":"Arterial thrombosis\u2014insidious, unpredictable and deadly","volume":"17","author":"Jackson","year":"2011","journal-title":"Nat Med"},{"key":"2024110604202460200_jphp13363-cit-0004","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.phymed.2015.11.019","article-title":"Barrier protective effect of asiatic acid in TNF-\u03b1-induced activation of human aortic endothelial cells","volume":"23","author":"Fong","year":"2016","journal-title":"Phytomedicine"},{"key":"2024110604202460200_jphp13363-cit-0005","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11239-005-0343-8","article-title":"Losartan and simvastatin inhibit platelet activation in hypertensive patients","volume":"18","author":"Nomura","year":"2004","journal-title":"J Thromb Thrombolysis"},{"key":"2024110604202460200_jphp13363-cit-0006","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1590\/1414-431x20144182","article-title":"High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients","volume":"48","author":"Chan","year":"2015","journal-title":"Braz J Med Biol Res"},{"key":"2024110604202460200_jphp13363-cit-0007","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2174\/0929867321666131227162950","article-title":"Obesity, hypertension and hypercholesterolemia as risk factors for atherosclerosis leading to ischemic events","volume":"21","author":"van Rooy","year":"2014","journal-title":"Curr Med Chem"},{"key":"2024110604202460200_jphp13363-cit-0008","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/01.HYP.18.2.132","article-title":"Endothelial dysfunction and subendothelial monocyte macrophages in hypertension. 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