{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:42:45Z","timestamp":1756309365240,"version":"3.37.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Umbelliprenin (UMB) is a prenylated coumarin that acts as an in vitro antioxidant and inhibits lipoxygenase managing the inflammation pathways, while in vivo it exerts anti-inflammatory activities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, neuropathic pain was induced by four intraperitoneal doses of 2 mg\/kg per day of paclitaxel (PTX) on days 1, 3, 5 and 7. Here, 49 male mice were randomly divided in the following groups: sham (not treated animals), negative control (PTX-treated receiving normal saline), single-dose UMB 6.25, 12.5 and 25 mg\/kg groups (PTX-treated receiving UMB 6.25, 12.5 and 25 mg\/kg, respectively), prevention (PTX-treated receiving PTX along with UMB 12.5 mg\/kg on days 1, 3, 5 and 7) and positive control group (PTX-treated receiving imipramine 10 mg\/kg as acute treatment). Hot-plate test was done to assess response to heat. Finally, interleukin (IL)-6 levels in the sciatic nerve and lipid peroxidation in sera were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Umbelliprenin was found equally effective for acute treatment with imipramine, when comparing the prevention group and the positive control group. Single, 25 mg\/kg UMB effectively attenuated hyperalgesia, lipid peroxidation and IL-6 levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Umbelliprenin alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.13365","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:37:10Z","timestamp":1601325430000},"page":"1822-1829","source":"Crossref","is-referenced-by-count":9,"title":["Umbelliprenin relieves paclitaxel-induced neuropathy"],"prefix":"10.1093","volume":"72","author":[{"given":"Jafar","family":"Shahraki","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences , Zabol,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad,","place":["Iran"]},{"name":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences , 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