{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:55:20Z","timestamp":1791039320575,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T00:00:00Z","timestamp":1351555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melatonin membrane (\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    2) and nuclear (\n                    <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\n                    \u03b1) receptors have been identified in several mammalian tissues, including the liver. The mechanisms regulating hepatic melatonin receptors are yet unknown. This study investigated whether these receptors exhibit daily changes and the effects of melatonin on their levels. Our results show that m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s for\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    1\/\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    2 receptors exhibit circadian rhythms that were followed by rhythms in their respective protein levels; the acrophases for the two rhythms were reached at 04:00 and 05:00\u00a0hr, respectively. Pinealectomy blunted the rhythms in both m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s and protein levels. In contrast, m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    and protein levels of nuclear receptor\n                    <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\n                    \u03b1 increased significantly after pinealectomy. The cycles of the latter receptor also exhibited circadian rhythms which peaked at 03:00 and 03:45\u00a0hr, respectively. Melatonin administration (10\u2013200\u00a0mg\/kg) increased in a dose\u2010dependent manner the protein content of\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    1\/\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    2 receptors, with no effects on ROR\u03b1. Lunzindole treatment, however, did not affect melatonin receptor expression or content of either the membrane or nuclear receptors. Together with previously published findings which demonstrated the intracellular distribution of melatonin in rat liver, the current results support the conclusion that the circadian rhythms of\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    1\/MT2 and ROR\u03b1 receptors are under the control of the serum and intracellular melatonin levels. Moreover, the induction of\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    1\/\n                    <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                    2 receptors after the administration of high doses of melatonin further suggests that the therapeutic value of melatonin may not be restricted to only low doses of the indoleamine.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12019","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T03:01:08Z","timestamp":1351220468000},"page":"313-321","source":"Crossref","is-referenced-by-count":78,"title":["Analysis of the daily changes of melatonin receptors in the rat liver"],"prefix":"10.1111","volume":"54","author":[{"given":"Carmen","family":"Venegas","sequence":"first","affiliation":[{"name":"Instituto de Biotecnolog\u00eda Centro de Investigaci\u00f3n Biom\u00e9dica Parque Tecnol\u00f3gico de Ciencias de 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de Biotecnolog\u00eda Centro de Investigaci\u00f3n Biom\u00e9dica Parque Tecnol\u00f3gico de Ciencias de la Salud"},{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina Universidad de Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine","family":"Escames","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda Centro de Investigaci\u00f3n Biom\u00e9dica Parque Tecnol\u00f3gico de Ciencias de la Salud"},{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina Universidad de Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda Centro de Investigaci\u00f3n Biom\u00e9dica Parque Tecnol\u00f3gico de Ciencias de la Salud"},{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina Universidad de Granada Granada 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