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It is considered an important antioxidant and may retard the development of some neurodegenerative diseases and cancer. Previous studies in humans have measured melatonin metabolites in urine and have indicated that melatonin\u2010containing foods may provide dietary melatonin. This study tested whether the consumption of fruits or fruit juice containing melatonin would influence the serum melatonin concentration and antioxidant status. In this crossover study, 12 healthy male volunteers took either juice extracted from one kilogram of orange or pineapple or two whole bananas, with a 1\u2010wk washout period between the fruit or fruit juices. An enzyme\u2010linked immunosorbent (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) assay was used to determine the serum melatonin concentration. Serum antioxidant capacity was determined by ferric reducing antioxidant power (<jats:styled-content style=\"fixed-case\">FRAP<\/jats:styled-content>) assay and oxygen radical antioxidant capacity (<jats:styled-content style=\"fixed-case\">ORAC<\/jats:styled-content>) assay. The highest serum melatonin concentration was observed at 120\u00a0min after fruit consumption, and compared with before consumption levels, their values were significantly increased for pineapple (146 versus 48\u00a0pg\/mL <jats:italic>P\u00a0<\/jats:italic>=\u00a00.002), orange (151 versus 40\u00a0pg\/mL, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.005), and banana (140 versus 32\u00a0pg\/mL, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.008), respectively. Serum antioxidant capacity following fruit consumption also significantly increased in both the <jats:styled-content style=\"fixed-case\">FRAP<\/jats:styled-content> (7\u201314% increase, <jats:italic>P\u00a0<\/jats:italic>\u2264\u00a00.004) and <jats:styled-content style=\"fixed-case\">ORAC<\/jats:styled-content> (6\u20139% increase, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.002) assays. Both the serum <jats:styled-content style=\"fixed-case\">FRAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ORAC<\/jats:styled-content> values strongly correlated with serum melatonin concentration for all three fruits. These findings suggest that tropical fruit consumption increases the serum melatonin concentrations and also raises the antioxidant capacity in the serum of healthy volunteers in proportion to serum melatonin levels.<\/jats:p>","DOI":"10.1111\/jpi.12025","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T04:17:36Z","timestamp":1349410656000},"page":"58-64","source":"Crossref","is-referenced-by-count":159,"title":["Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers"],"prefix":"10.1111","volume":"55","author":[{"given":"Manit","family":"Sae\u2010Teaw","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Ubon Ratchathani University Ubon Ratchathani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Johns","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Khon Kaen University Khon 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