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This study was undertaken to examine whether melatonin could potentiate low dose L\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content> effects in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (<jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>)\u2010induced experimental parkinsonism. Mice were treated with the parkinsonian neurotoxin, <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>, and different doses of melatonin and low doses of L\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content>. Behavior, striatal histology, and dopamine metabolism were evaluated on the 7th day. <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010induced striatal dopamine loss was not modified by melatonin administration (10\u201330\u00a0mg\/kg; i.p. at 10\u2010hr intervals, 6 times; or at 2\u2010hr intervals, by day). However, low doses of L\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content> (5\u00a0mg\/kg, by oral gavage) administered alone or along with melatonin (10\u00a0mg\/kg, i.p.) twice everyday for 2\u00a0days, 10\u00a0hr apart, after two doses of <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> significantly attenuated striatal dopamine loss and provided improvements in both catalepsy and akinesia. Additionally, Golgi\u2010impregnated striatal sections showed preservation of the medium spiny neurons, which have been damaged in <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010treated mouse. The results demonstrated that melatonin, but not L\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content>, restored spine density and spine morphology of medium spiny neurons in the striatum and suggest that melatonin could be an ideal adjuvant to L\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content> therapy in Parkinson's disease, and by the use of this neurohormone, it is possible to bring down the therapeutic doses of L\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jpi.12076","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T14:00:46Z","timestamp":1373292046000},"page":"304-312","source":"Crossref","is-referenced-by-count":44,"title":["Melatonin synergizes with low doses of L\u2010<scp>DOPA<\/scp> to improve dendritic spine density in the mouse striatum in experimental Parkinsonism"],"prefix":"10.1111","volume":"55","author":[{"given":"Amit","family":"Naskar","sequence":"first","affiliation":[{"name":"Division of Cell Biology and Physiology CSIR\u2010Indian Institute of Chemical Biology Jadavpur Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamilarasan","family":"Manivasagam","sequence":"additional","affiliation":[{"name":"Division of Cell Biology and Physiology CSIR\u2010Indian Institute of Chemical Biology Jadavpur Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Division of Cell Biology and Physiology CSIR\u2010Indian Institute of Chemical Biology Jadavpur Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghavendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cell Biology and Physiology CSIR\u2010Indian Institute of Chemical Biology Jadavpur 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