{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:13:40Z","timestamp":1789996420416,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Proyecto de Investigaci\u00f3n Plurianual","award":["2605"],"award-info":[{"award-number":["2605"]}]},{"name":"Proyecto de Investigaci\u00f3n en Ciencia y Tecnolog\u00eda","award":["0813"],"award-info":[{"award-number":["0813"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children. At present, there is no efficient therapy to prevent preterm labor. A large body of evidence suggests that intra\u2010amniotic infections may be a significant and potentially preventable cause of preterm birth. This work assessed the effect of melatonin in a murine model of inflammation\u2010associated preterm delivery which mimics central features of preterm infection in humans. For this purpose, preterm labor was induced in\n                    <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\n                    \/c mice by intraperitoneal injections of bacterial lipopolysaccharide (\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    ) at 10.00\u00a0hr (10\u00a0\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    ) and 13.00\u00a0hr (20\u00a0\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    ) on day 15 of pregnancy. On day 14 of pregnancy, a pellet of melatonin (25\u00a0mg) had been subcutaneously implanted into a group of animals. In the absence of melatonin, a 100% incidence of preterm birth was observed in\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    \u2010treated animals, and the fetuses showed widespread damage. By comparison, treatment with melatonin prevented preterm birth in 50% of the cases, and all pups from melatonin\u2010treated females were born alive and their body weight did not differ from control animals. Melatonin significantly prevented the\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    \u2010induced rises in uterine prostaglandin (\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    ) E\n                    <jats:sub>2<\/jats:sub>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content>\n                    <jats:sub>\n                      2\n                      <jats:italic>\u03b1<\/jats:italic>\n                    <\/jats:sub>\n                    , and cyclooxygenase\u20102 protein levels. In addition, melatonin prevented the\n                    <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\n                    \u2010induced increase in uterine nitric oxide (\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    ) production, inducible\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    synthase protein, and tumor necrosis factor\u2010alpha (\n                    <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) levels. Collectively, our results suggest that melatonin could be a new therapeutic tool to prevent preterm labor and to increase offspring survival.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12108","type":"journal-article","created":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T10:12:57Z","timestamp":1386411177000},"page":"154-162","source":"Crossref","is-referenced-by-count":44,"title":["Melatonin prevents experimental preterm labor and increases offspring survival"],"prefix":"10.1111","volume":"56","author":[{"given":"Ana P.","family":"Dom\u00ednguez Rubio","sequence":"first","affiliation":[{"name":"Laboratory of Physiopathology of Pregnancy and Labor CEFyBO (CONICET\/UBA) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela S.","family":"Sordelli","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Pharmacology of Reproduction CEFyBO (CONICET\/UBA) Buenos Aires 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