{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:22:52Z","timestamp":1790713372202,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T00:00:00Z","timestamp":1393027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council (NHMRC) of Australia"},{"name":"Cerebral Palsy Alliance of Australia"},{"name":"5 Point Foundation"},{"name":"Victorian Government's Operational Infrastructure Support Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fetal intrauterine growth restriction (\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    ) is a serious pregnancy complication associated with increased rates of perinatal morbidity and mortality, and ultimately with long\u2010term neurodevelopmental impairments. No intervention currently exists that can improve the structure and function of the\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    brain before birth. Here, we investigated whether maternal antenatal melatonin administration reduced brain injury in ovine\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    was induced in pregnant sheep at 0.7 gestation and a subset of ewes received melatonin via intravenous infusion until term.\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    \u00a0+\u00a0melatonin (\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    \u00a0+\u00a0\n                    <jats:styled-content style=\"fixed-case\">MLT<\/jats:styled-content>\n                    ) and control lambs were born naturally, neonatal behavioral assessment was used to examine neurological function and at 24\u00a0hr after birth the brain was collected for the examination of neuropathology. Compared to control lambs,\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    lambs took significantly longer to achieve normal neonatal lamb behaviors, such as standing and suckling.\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    brains showed widespread cellular and axonal lipid peroxidation, and white matter hypomyelination and axonal damage. Maternal melatonin administration ameliorated oxidative stress, normalized myelination and rescued axonopathy within\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    lamb brains, and\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    \u00a0+\u00a0\n                    <jats:styled-content style=\"fixed-case\">MLT<\/jats:styled-content>\n                    lambs demonstrated significant functional improvements including a reduced time taken to attach to and suckle at the udder after birth. Based on these observations, we began a pilot clinical trial of oral melatonin administration to women with an\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    fetus. Maternal melatonin was not associated with adverse maternal or fetal effects and it significantly reduced oxidative stress, as evidenced by reduced malondialdehyde levels, in the\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    \u00a0+\u00a0\n                    <jats:styled-content style=\"fixed-case\">MLT<\/jats:styled-content>\n                    placenta compared to\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    alone. Melatonin should be considered for antenatal neuroprotective therapy in human\n                    <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/jpi.12121","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T13:32:50Z","timestamp":1390483970000},"page":"283-294","source":"Crossref","is-referenced-by-count":153,"title":["Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction"],"prefix":"10.1111","volume":"56","author":[{"given":"Suzanne L.","family":"Miller","sequence":"first","affiliation":[{"name":"The Ritchie Centre Monash Institute of Medical Research Monash University Clayton Vic. Australia"},{"name":"Department of Obstetrics &amp; Gynaecology Southern Clinical School Monash University Clayton Vic. 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