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This study investigated whether melatonin prevents<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>remodeling and improves survival in isoproterenol\u2010induced heart failure. In the first experiment, four groups of 3\u2010month\u2010old male Wistar rats (12 per group) were treated for 2\u00a0wk as follows: controls, rats treated with melatonin (10\u00a0mg\/kg\/day) (M), rats treated with isoproterenol (5\u00a0mg\/kg\/day intraperitoneally the second week) (Iso), and rats treated with melatonin (2\u00a0wk) and isoproterenol (the second week) in corresponding doses (IsoM). In the second experiment, 30 rats were treated with isoproterenol and 30 rats with isoproterenol plus melatonin for a period of 28\u00a0days and their mortality was investigated. Isoproterenol\u2010induced heart failure with hypertrophy of the left and right ventricles (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>), lowered systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) and elevated pulmonary congestion. Fibrotic rebuilding was accompanied by alterations of tubulin level in the<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>and oxidative stress development. Melatonin failed to reduce the weight of the<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>; however, it curtailed the weight of the lungs and attenuated the decline in<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>. Moreover, melatonin decreased the level of oxidative stress and of insoluble and total collagen and partly prevented the beta\u2010tubulin alteration in the<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>. Most importantly, melatonin reduced mortality and prolonged the average survival time. In conclusion, melatonin exerts cardioprotective effects and improves outcome in a model of isoproterenol\u2010induced heart damage. The antiremodeling effect of melatonin may be of potential benefit in patients with heart failure.<\/jats:p>","DOI":"10.1111\/jpi.12154","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T16:07:46Z","timestamp":1403107666000},"page":"177-184","source":"Crossref","is-referenced-by-count":85,"title":["Melatonin reduces cardiac remodeling and improves survival in rats with isoproterenol\u2010induced heart failure"],"prefix":"10.1111","volume":"57","author":[{"given":"Fedor","family":"Simko","sequence":"first","affiliation":[{"name":"Department of Pathophysiology School of Medicine Comenius University Bratislava Slovak Republic"},{"name":"3<sup>rd<\/sup> Clinic of Medicine School of Medicine Comenius University Bratislava Slovak Republic"},{"name":"Institute of Experimental Endocrinology Slovak Academy of Sciences Bratislava Slovak Republic"},{"name":"Center of Excellence NOREG Bratislava Slovak 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