{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:34:45Z","timestamp":1792974885871,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study tests the hypothesis that combined melatonin and adipose\u2010derived mesenchymal stem cell (ADMSC, 1.2\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> given intravenously) treatment offer superior protection against cyclophosphamide (CYP 150\u00a0mg\/kg)\u2010induced acute interstitial cystitis (AIC) in rats. Male adult Sprague\u2010Dawley rats were treated as follows: sham controls, AIC alone, AIC + melatonin, AIC + ADMSC, and AIC + melatonin +ADMSC. When melatonin was used, it was given as follows: 20\u00a0mg\/kg at 30\u00a0min after CYP and 50\u00a0mg\/kg at 6 and 18\u00a0hr after CYP. Twenty\u2010four\u2010hour urine volume, urine albumin level, and severity of hematuria were highest in AIC rats and lowest in the controls; likewise urine volume was higher in AIC + melatonin rats than in AIC + ADMSC and AIC + melatonin + ADMSC treated rats; in all cases, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001. The numbers of CD14+, CD74+, CD68+, MIP+, Cox\u20102+, substance P+, cells and protein expression of IL\u20106, IL\u201012, RANTES, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, NF\u2010<jats:italic>\u03ba<\/jats:italic>B, MMP\u20109, <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content> (i.e. inflammatory biomarkers), glycosaminoglycan level, expression of oxidized protein, and protein expression of reactive oxygen species (NOX\u20101, NOX\u20102, NOX\u20104) in the bladder tissue exhibited an identical pattern compared with that of hematuria among the five groups (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The integrity of epithelial layer and area of collagen deposition displayed an opposite pattern compared to that of hematuria among all groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The cellular expressions of antioxidants (GR, GPx, HO\u20101, NQO 1) showed a significant progressive increase form controls to AIC + melatonin + ADMSC (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Combined regimen of melatonin and ADMSC was superior to either alone in protecting against CYP\u2010induced AIC.<\/jats:p>","DOI":"10.1111\/jpi.12164","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T13:39:59Z","timestamp":1407332399000},"page":"248-261","source":"Crossref","is-referenced-by-count":71,"title":["Melatonin treatment further improves adipose\u2010derived mesenchymal stem cell therapy for acute interstitial cystitis in rat"],"prefix":"10.1111","volume":"57","author":[{"given":"Yen\u2010Ta","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Ju","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University 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