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Melatonin, a natural secretory product of the pineal gland, exerts neuroprotective effects through the activation of <jats:italic>\u03b2<\/jats:italic>\u2010catenin. In this study, melatonin increased <jats:italic>\u03b2<\/jats:italic>\u2010catenin protein expression and activation in human neuroblastoma cell lines <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SY<\/jats:styled-content>5Y cells. Melatonin also inhibited PrP (106\u2013126)\u2010induced neurotoxicity and the inhibition attenuated by treatment of <jats:italic>\u03b2<\/jats:italic>\u2010catenin inhibitor <jats:styled-content style=\"fixed-case\">ICG<\/jats:styled-content>\u2010001. Activation of <jats:italic>\u03b2<\/jats:italic>\u2010catenin blocked PrP (106\u2013126)\u2010mediated downregulation of anti\u2010apoptotic protein survivin and Bcl\u20102. Reduction of mitochondrial membrane potential, translocation of Bax, and cytochrome <jats:italic>c<\/jats:italic> release which induced by PrP (106\u2013126) treatment were inhibited by <jats:italic>\u03b2<\/jats:italic>\u2010catenin activation, which contributed to prevented PrP (106\u2013126)\u2010induced neuronal cell death. In conclusion, <jats:italic>\u03b2<\/jats:italic>\u2010catenin activation by melatonin prevented PrP (106\u2013126)\u2010induced neuronal cell death through regulating anti\u2010apoptotic proteins and mitochondrial pathways. These results also suggest the therapeutic value of Wnt\/<jats:italic>\u03b2<\/jats:italic>\u2010catenin signaling in prion\u2010related disorders as influenced by melatonin.<\/jats:p>","DOI":"10.1111\/jpi.12182","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T06:40:05Z","timestamp":1411540805000},"page":"427-434","source":"Crossref","is-referenced-by-count":38,"title":["Melatonin\u2010mediated <i>\u03b2<\/i>\u2010catenin activation protects neuron cells against prion protein\u2010induced neurotoxicity"],"prefix":"10.1111","volume":"57","author":[{"given":"Jae\u2010Kyo","family":"Jeong","sequence":"first","affiliation":[{"name":"Bio\u2010Safety Research Institute College of Veterinary Medicine Chonbuk National University Jeonju Jeonbuk South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Bio\u2010Safety Research Institute College of Veterinary 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