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Assuming that the circadian synchronization of clock genes can play a role in the regulation of energy metabolism and it is influenced by melatonin, our study was designed to assess possible alterations as a consequence of melatonin absence on the circadian expression of clock genes in the epididymal adipose tissue of male\n                    <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                    istar rats and the possible metabolic repercussions to this tissue. Our data show that pinealectomy indeed has impacts on molecular events: it abolishes the daily pattern of the expression of\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    lock,\n                    <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    er2, and\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    ry1 clock genes and\n                    <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    par\u03b3 expression, significantly increases the amplitude of daily expression of Rev\u2010erb\u03b1, and affects the pattern of and impairs adipokine production, leading to a decrease in leptin levels. However, regarding some metabolic aspects of adipocyte functions, such as its ability to synthesize triacylglycerols from glucose along 24\u00a0hr, was not compromised by pinealectomy, although the daily profile of the lipogenic enzymes expression (\n                    <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\n                    \u2010citrate lyase, malic enzyme, fatty acid synthase, and glucose\u20106\u2010phosphate dehydrogenase) was abolished in pinealectomized animals.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12211","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T01:39:16Z","timestamp":1422409156000},"page":"251-261","source":"Crossref","is-referenced-by-count":59,"title":["Pinealectomy interferes with the circadian clock genes expression in white adipose tissue"],"prefix":"10.1111","volume":"58","author":[{"given":"Talita da Silva Mendes","family":"de 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