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We examined the effects of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">SNAT<\/jats:styled-content>\n                    <\/jats:italic>\n                    gene inactivation in two\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    T\u2010\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    insertion mutant lines. After inoculation with the avirulent pathogen\n                    <jats:italic>Pseudomonas syringe<\/jats:italic>\n                    pv. tomato\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    3000 harboring the elicitor avrRpt2 (\n                    <jats:italic>Pst<\/jats:italic>\n                    \u2010avrRpt2), melatonin levels in the\n                    <jats:italic>snat<\/jats:italic>\n                    knockout mutant lines were 50% less than in wild\u2010type\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    Col\u20100 plants. The\n                    <jats:italic>snat<\/jats:italic>\n                    knockout mutant lines exhibited susceptibility to pathogen infection that coincided with decreased induction of defense genes including\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    , and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">PDF<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    .\n                    <jats:italic>2<\/jats:italic>\n                    . Because melatonin acts upstream of salicylic acid (\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    ) synthesis, the reduced melatonin levels in the\n                    <jats:italic>snat<\/jats:italic>\n                    mutant lines led to decreased\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    levels compared to wild\u2010type, suggesting that the increased pathogen susceptibility of the\n                    <jats:italic>snat<\/jats:italic>\n                    mutant lines could be attributed to decreased\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    levels and subsequent attenuation of defense gene induction. Exogenous melatonin treatment failed to induce defense gene expression in\n                    <jats:italic>nahG Arabidopsis<\/jats:italic>\n                    plants, but restored the induction of defense gene expression in the\n                    <jats:italic>snat<\/jats:italic>\n                    mutant lines. In addition, melatonin caused translocation of\n                    <jats:styled-content style=\"fixed-case\">NPR<\/jats:styled-content>\n                    1 (nonexpressor of\n                    <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>\n                    1) protein from the cytoplasm into the nucleus indicating that melatonin\u2010elicited pathogen resistance in response to avirulent pathogen attack is\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    \u2010dependent in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/jpi.12214","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T01:03:00Z","timestamp":1423098180000},"page":"291-299","source":"Crossref","is-referenced-by-count":240,"title":["<i>Arabidopsis<\/i>\n                    serotonin\n                    <i>N<\/i>\n                    \u2010acetyltransferase knockout mutant plants exhibit decreased melatonin and salicylic acid levels resulting in susceptibility to an avirulent pathogen"],"prefix":"10.1111","volume":"58","author":[{"given":"Hyoung Yool","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biotechnology Bioenergy Research Center Chonnam National University Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bioenergy Research Center Chonnam National University Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun\u2010Xian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology The University of Texas Health Science Center at San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel 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