{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:44:49Z","timestamp":1772995489927,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Chang Gung Memorial Hospital, Chang Gung University","award":["CMRPG8D1301"],"award-info":[{"award-number":["CMRPG8D1301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n We tested the hypothesis that combined melatonin and autologous adipose\u2010derived mesenchymal stem cells (\n ADMSC<\/jats:styled-content>\n ) was superior to either alone against small bowel ischemia\u2010reperfusion (\n SBIR<\/jats:styled-content>\n ) injury induced by superior mesenteric artery clamping for 30\u00a0min followed by reperfusion for 72\u00a0hr. Male adult Sprague Dawley rats (n\u00a0=\u00a050) were equally categorized into sham\u2010operated controls\n SC<\/jats:styled-content>\n ,\n SBIR<\/jats:styled-content>\n ,\n SBIR<\/jats:styled-content>\n \u2010\n ADMSC<\/jats:styled-content>\n (1.0\u00a0\u00d7\u00a010\n 6<\/jats:sup>\n intravenous and 1.0\u00a0\u00d7\u00a010\n 6<\/jats:sup>\n intrajejunal injection),\n SBIR<\/jats:styled-content>\n \u2010melatonin (intraperitoneal 20\u00a0mg\/kg at 30\u00a0min after\n SI<\/jats:styled-content>\n ischemia and 50\u00a0mg\/kg at 6 and 18\u00a0hr after\n SI<\/jats:styled-content>\n reperfusion), and\n SBIR<\/jats:styled-content>\n \u2010\n ADMSC<\/jats:styled-content>\n \u2010melatonin groups. The results demonstrated that the circulating levels of\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n ,\n MPO<\/jats:styled-content>\n , LyG6+ cells,\n CD<\/jats:styled-content>\n 68+ cells,\n WBC<\/jats:styled-content>\n count, and gut permeability were highest in\n SBIR<\/jats:styled-content>\n and lowest in\n SC<\/jats:styled-content>\n , significantly higher in\n SBIR<\/jats:styled-content>\n \u2010\n ADMSC<\/jats:styled-content>\n group and further increased in\n SBIR<\/jats:styled-content>\n \u2010melatonin group than in the combined therapy group (all\n P<\/jats:italic>\n \u00a0<\u00a00.001). The ischemic mucosal damage score, the protein expressions of inflammation (\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n ,\n NF<\/jats:styled-content>\n \u2010\n \u03ba<\/jats:italic>\n B,\n MMP<\/jats:styled-content>\n \u20109,\n MPO<\/jats:styled-content>\n , and\n iNOS<\/jats:styled-content>\n ), oxidative stress (\n NOX<\/jats:styled-content>\n \u20101,\n NOX<\/jats:styled-content>\n \u20102, and oxidized protein), apoptosis (\n APAF<\/jats:styled-content>\n \u20101, mitochondrial Bax, cleaved caspase\u20103 and\n PARP<\/jats:styled-content>\n ), mitochondrial damage (cytosolic cytochrome C) and\n DNA<\/jats:styled-content>\n damage (\n \u03b3<\/jats:italic>\n \u2010H2\n AX<\/jats:styled-content>\n ) markers, as well as cellular expressions of proliferation (\n PCNA<\/jats:styled-content>\n ), apoptosis (caspase\u20103,\n TUNEL<\/jats:styled-content>\n assay), and\n DNA<\/jats:styled-content>\n damage (\n \u03b3<\/jats:italic>\n \u2010H2\n AX<\/jats:styled-content>\n ) showed an identical pattern, whereas mitochondrial cytochrome C exhibited an opposite pattern compared to that of inflammation among all groups (all\n P<\/jats:italic>\n \u00a0<\u00a00.001). Besides, antioxidant expressions at protein (\n NQO<\/jats:styled-content>\n \u20101,\n GR<\/jats:styled-content>\n , and\n GP<\/jats:styled-content>\n x) and cellular (\n HO<\/jats:styled-content>\n \u20101) levels progressively increased from\n SC<\/jats:styled-content>\n to the combined treatment group (all\n P<\/jats:italic>\n \u00a0<\u00a00.001). In conclusion, combined melatonin\u2010\n ADMSC<\/jats:styled-content>\n treatment offered additive beneficial effect against\n SBIR<\/jats:styled-content>\n injury.\n <\/jats:p>","DOI":"10.1111\/jpi.12251","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T16:52:34Z","timestamp":1432572754000},"page":"206-220","source":"Crossref","is-referenced-by-count":75,"title":["Protective effect of melatonin\u2010supported adipose\u2010derived mesenchymal stem cells against small bowel ischemia\u2010reperfusion injury in rat"],"prefix":"10.1111","volume":"59","author":[{"given":"Chia\u2010Lo","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Hsun","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk\u2010Kwan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine E\u2010Da Hospital I\u2010Shou University School of Medicine for International Students Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of General Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Ju","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Hung","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Yi","family":"Zhen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Tan","family":"Chai","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Ying","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Shen","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh\u2010Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Hwa","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hon\u2010Kan","family":"Yip","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Center for Translational Research in Biomedical Sciences Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital China Medical University Taichung 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