{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:26:57Z","timestamp":1790072817286,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["81325009"],"award-info":[{"award-number":["81325009"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s)\u2010based therapy provides a promising therapy for the ischemic heart disease (<jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>). However, engrafted<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s are subjected to acute cell death in the ischemic microenvironment, characterized by excessive inflammation and oxidative stress in the host's infarcted myocardium. Melatonin, an indole, which is produced by many organs including pineal gland, has been shown to protect bone marrow<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s against apoptosis although the mechanism of action remains elusive. Using a murine model of myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>), this study was designed to evaluate the impact of melatonin on adipose\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s)\u2010based therapy for<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>and the underlying mechanism involved with a focus on silent information regulator 1(<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1) signaling. Our results demonstrated that melatonin promoted functional survival of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s in infarcted heart and provoked a synergetic effect with<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s to restore heart function. This in vivo effect of melatonin was associated with alleviated inflammation, apoptosis, and oxidative stress in infarcted heart. In vitro studies revealed that melatonin exert cytoprotective effects on<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s against hypoxia\/serum deprivation (H\/<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) injury<jats:italic>via<\/jats:italic>attenuating inflammation, apoptosis, and oxidative stress. Mechanistically, melatonin enhanced<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 signaling, which was accompanied with the increased expression of anti\u2010apoptotic protein Bcl2, and decreased the expression of Ac\u2010FoxO1, Ac\u2010p53, Ac\u2010<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">\u039aB<\/jats:styled-content>, and Bax. Taken together, our findings indicated that melatonin facilitated<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s\u2010based therapy in<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, possibly through promoting survival of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s<jats:italic>via<\/jats:italic><jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 signaling. Our data support the promise of melatonin as a novel strategy to improve<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010based therapy for<jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>, possibly through<jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1 signaling evocation.<\/jats:p>","DOI":"10.1111\/jpi.12299","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T12:16:25Z","timestamp":1448540185000},"page":"178-192","source":"Crossref","is-referenced-by-count":105,"title":["Melatonin facilitates adipose\u2010derived mesenchymal stem cells to repair the murine infarcted heart<i>via<\/i>the SIRT1 signaling pathway"],"prefix":"10.1111","volume":"60","author":[{"given":"Dong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"},{"name":"Department of Cardiology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhe","family":"Gao","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"},{"name":"Department of Cardiology Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.05.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.07.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0333-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5683"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0168-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.08.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12085"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12173"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2012.01014.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12128"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12175"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12162"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12267"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12254"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12042"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12086"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12051"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12119"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2012.01030.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12161"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12054"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12193"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12113"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00858.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00459.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-1000"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12610"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01140.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1265"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12251"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12179"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12020"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"A9567","DOI":"10.1161\/circ.128.suppl_22.A9567","article-title":"Melatonin treatment improves adipose\u2010derived mesenchymal stem cell therapy for acute lung ischemia\u2010reperfusion injury","volume":"128","author":"Chua S","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368909788534951"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0394-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0405-367"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.08.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/15701611113119990003"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12272"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn335"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130526.20854.fa"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.06.010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.232306"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.10.004"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00776.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0684-6"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12250"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12133"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002480"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2012.00991.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.03.009"}],"container-title":["Journal of Pineal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpi.12299","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpi.12299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpi.12299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T18:22:38Z","timestamp":1718216558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpi.12299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/jpi.12299"],"URL":"https:\/\/doi.org\/10.1111\/jpi.12299","archive":["Portico"],"relation":{},"ISSN":["0742-3098","1600-079X"],"issn-type":[{"value":"0742-3098","type":"print"},{"value":"1600-079X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}