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Recent advances in stem cell (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) biology have opened an avenue to exploring its therapeutic potential in various disease entities, especially those that are ischemia\u2010related and refractory to conventional treatment. A number of experimental studies and clinical trials have already demonstrated promising outcomes. On the other hand, <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> therapy is associated with major problems. For instance, ischemia, inflammation, and oxidative stress are some of the factors unfavorable for <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> survival once <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>s are implanted into the ischemic area in an attempt to enhance tissue regeneration and restore organ function. Melatonin, which is originally derived from pineal gland in the regulation of human circadian rhythms and sleep, is a potent free radical scavenger and metal chelator with the capacity to alleviate oxidative stress and inflammatory reactions as well as stabilizing cell membranes. Accumulating data have demonstrated that melatonin\u2010supported <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> therapy is superior to <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> alone for improving ischemia\u2010related organ dysfunction. In this review, we describe and interpret the potential role of melatonin in sustaining the survival and preserving the functional integrity of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jpi.12372","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T02:10:33Z","timestamp":1476411033000},"source":"Crossref","is-referenced-by-count":35,"title":["Melatonin enhances survival and preserves functional integrity of stem cells: A review"],"prefix":"10.1111","volume":"62","author":[{"given":"Mel S.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Orthopedics Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung\u2010Cheng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Kaohsiung Chang Gung Memorial Hospital and Chang Gung 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