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Thus, compounds targeting <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage response (<jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content>) hold great promise in cancer therapy. A great deal of effort, in pursuit of new anticancer drugs, has been devoted to understanding the basic mechanisms and functions of the cellular <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair machinery. Melatonin, a widely produced indoleamine in all organisms, is associated with a reduced risk of cancer and has multiple regulatory roles on the different aspects of the <jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair. Herein, we have mainly discussed how defective components in different <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair machineries, including homologous recombination (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), nonhomologous end\u2010joining (<jats:styled-content style=\"fixed-case\">NHEJ<\/jats:styled-content>), base excision repair (<jats:styled-content style=\"fixed-case\">BER<\/jats:styled-content>), nucleotide excision repair (<jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content>), and finally <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mismatch repair (<jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>), can contribute to the risk of cancer. Melatonin biosynthesis, mode of action, and antioxidant effects are reviewed along with the means by which the indoleamine regulates <jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content> at the transduction, mediation, and functional levels. Finally, we summarize recent studies that illustrate how melatonin can be combined with <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010damaging agents to improve their efficacy in cancer therapy.<\/jats:p>","DOI":"10.1111\/jpi.12416","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T07:47:40Z","timestamp":1493106460000},"source":"Crossref","is-referenced-by-count":144,"title":["Melatonin: A pleiotropic molecule that modulates <scp>DNA<\/scp> damage response and repair pathways"],"prefix":"10.1111","volume":"63","author":[{"given":"Maryam","family":"Majidinia","sequence":"first","affiliation":[{"name":"Solid Tumor Research Center Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sadeghpour","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine and Shohada Educational Hospital Tabriz University of 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