{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:43:55Z","timestamp":1778175835159,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81470415"],"award-info":[{"award-number":["81470415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570230"],"award-info":[{"award-number":["81570230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570231"],"award-info":[{"award-number":["81570231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570232"],"award-info":[{"award-number":["81570232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key Research and Development Program of China","award":["2016YFC1301900"],"award-info":[{"award-number":["2016YFC1301900"]}]},{"name":"the Natural Science Foundation of the Shaanxi Province","award":["2014JM4106"],"award-info":[{"award-number":["2014JM4106"]}]},{"name":"the Science and Technology Co-ordination and Innovation Project of the Shaanxi Province","award":["2015KTCL-03-04"],"award-info":[{"award-number":["2015KTCL-03-04"]}]},{"name":"the Subject Boosting Project of Xijing Hospital","award":["XJZT14203"],"award-info":[{"award-number":["XJZT14203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol. However, its role against pressure overload\u2010induced cardiac hypertrophy and the underlying mechanisms remains elusive. In this study, we investigated the pharmacological effects of melatonin on pathological cardiac hypertrophy induced by transverse aortic constriction (\n                    <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                    ). Male C57\n                    <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\n                    \/6 mice underwent\n                    <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                    or sham surgery at day 0 and were then treated with melatonin (20\u00a0mg\/kg\/day, via drinking water) for 4 or 8\u00a0weeks. The 8\u2010week survival rate following\n                    <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                    surgery was significantly increased by melatonin. Melatonin treatment for 8\u00a0weeks markedly ameliorated cardiac hypertrophy. Compared with the\n                    <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                    group, melatonin treatment for both 4 and 8\u00a0weeks reduced pulmonary congestion, upregulated the expression level of \u03b1\u2010myosin heavy chain, downregulated the expression level of \u03b2\u2010myosin heavy chain and atrial natriuretic peptide, and attenuated the degree of cardiac fibrosis. In addition, melatonin treatment slowed the deterioration of cardiac contractile function caused by pressure overload. These effects of melatonin were accompanied by a significant upregulation in the expression of peroxisome proliferator\u2010activated receptor\u2010gamma co\u2010activator\u20101 beta (\n                    <jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\n                    \u20101\u03b2) and the inhibition of oxidative stress. In vitro studies showed that melatonin also protects against angiotensin\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    \u2010induced cardiomyocyte hypertrophy and oxidative stress, which were largely abolished by knocking down the expression of\n                    <jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\n                    \u20101\u03b2 using small interfering\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    . In summary, our results demonstrate that melatonin protects against pathological cardiac hypertrophy induced by pressure overload through activating\n                    <jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\n                    \u20101\u03b2.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12433","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T10:56:39Z","timestamp":1500029799000},"source":"Crossref","is-referenced-by-count":52,"title":["EXPRESSION OF CONCERN: Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating\n                    <scp>PGC<\/scp>\n                    \u20101\u03b2: In vivo and in vitro studies"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-4213","authenticated-orcid":false,"given":"Mengen","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Jing","sequence":"additional","affiliation":[{"name":"Cell Engineering Research Center and Department of Cell Biology State Key Laboratory of Cancer Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Material Medical School of Pharmacy Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuju","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Brigade of Student Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Material Medical School of Pharmacy Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinghua","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology UT Health Science Center  San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-9133","authenticated-orcid":false,"given":"Shiqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308688"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001785"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011085"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300507"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.228437"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00386.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00749.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.1.184"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00158-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801317"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.3_Pt_2.II42"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12267"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12375"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.11.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12348"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.044"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00601.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030200"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303643200"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10210"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243964"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu164"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12157"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09130"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000252830.01581.fd"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1002.105225"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.211797"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(96)00003-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.020"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12154"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.737031"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.12.1.417"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85624"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030181.63741.56"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12067"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.06.001"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12054"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12357"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12085"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12378"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.01.009"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12360"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200301000-00028"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000358830.95439.e8"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309398"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000118586.38323.5b"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000164233.09448.B1"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijm.2016.2824"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.279760"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0338-0"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000078"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.3.353"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017920"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000022879.57270.11"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.044"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012630"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.4.386"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02860-7"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300575"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/703175"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12371"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000358831.33558.97"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12190"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12302"}],"updated-by":[{"DOI":"10.1111\/jpi.70119","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000}}],"container-title":["Journal of Pineal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpi.12433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpi.12433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpi.12433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpi.12433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:16:10Z","timestamp":1772990170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpi.12433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jpi.12433"],"URL":"https:\/\/doi.org\/10.1111\/jpi.12433","archive":["Portico"],"relation":{},"ISSN":["0742-3098","1600-079X"],"issn-type":[{"value":"0742-3098","type":"print"},{"value":"1600-079X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]},"article-number":"e12433"}}