{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:34:54Z","timestamp":1790681694929,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"University of Urbino Carlo Bo"},{"name":"Europe Against Infant Brain Injury (EURAIBI) Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Increasing evidence indicates that melatonin possesses protective effects toward different kinds of damage in various organs, including the brain. In a neonatal model of hypoxia\u2010ischemia (\n                    <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n                    ), melatonin was neuroprotective and preserved the expression of the silent information regulator 1 (\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1) 24\u00a0hours after the insult. This study aimed to gain more insight into the role of\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1 in the protective effect of melatonin after\n                    <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n                    by studying the early (1\u00a0hour) modulation of\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1 and its downstream targets, and the consequences on necrosis, apoptosis, autophagy, and glial cell activation. We found that melatonin administered 5\u00a0minutes after the ischemic insult significantly reduced necrotic cell death assessed 1\u00a0hour after its administration. In parallel, we found a reduced activation of the early phases of intrinsic apoptosis, detected by reduced\n                    <jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content>\n                    translocation to the mitochondria and preservation of the mitochondrial expression of cytochrome C, indicating a reduced outer mitochondrial membrane permeabilization in the melatonin\u2010treated ischemic animals. These effects were concomitant to increased expression and activity of\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1, reduced expression and acetylation of p53, and increased autophagy activation. Melatonin also reduced\n                    <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n                    \u2010induced glial cells activation.\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1 was expressed in neurons after\n                    <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n                    and melatonin but not in reactive glial cells expressing\n                    <jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>\n                    . Colocalization between\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>\n                    was found in some cells in control conditions. In summary, our results provide more insight into the connection between\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1 and melatonin in neuroprotection. The possibility that melatonin\u2010induced\n                    <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>\n                    1 activity might contribute to differentiate neuronal progenitor cells during the neurodegenerative process needs to be further investigated.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12434","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T10:56:41Z","timestamp":1500029801000},"source":"Crossref","is-referenced-by-count":59,"title":["Rapid modulation of the silent information regulator 1 by melatonin after hypoxia\u2010ischemia in the neonatal rat brain"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-3454","authenticated-orcid":false,"given":"Silvia","family":"Carloni","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u201cCarlo Bo\u201d  Urbino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Riparini","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u201cCarlo Bo\u201d  Urbino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Buonocore","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine Policlinico Le Scotte University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8438-9559","authenticated-orcid":false,"given":"Walter","family":"Balduini","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u201cCarlo Bo\u201d  Urbino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S115533"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/892624"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00649.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12360"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2015.1704"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00509.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150916848"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14048638"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12156"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12354"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.23.2888"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609554200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057111422103"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601913483767"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805711200"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009199"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24399"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00527-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.001222"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604392103"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1700"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0408-373"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13866"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701408194"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.06.009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600342"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.3.11261"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.016"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712145105"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179689"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.12.001"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601913479798"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001715"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601913484496"},{"key":"e_1_2_8_37_1","first-page":"1580","article-title":"Melatonin 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